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The authors design a Pt/CuInP₂S₆/graphene heterostructure that achieves polarity-switchable photovoltaic current modulated by ferroelectric polarization. This enables programmable in-sensor computing, achieving high-performance visual tasks.

The authors demonstrate that stable partial polarization control achieves more than 10¹⁰ write cycles in ferroelectric AlScN. Further, reducing capacitor diameter increases breakdown voltage, boosting endurance.

A library preparation method using anchored random reverse primer sequencing for quantitative analysis of novel gene fusions from low-input samples.

Spherical polar topological structures are of interest as they could enable high-density memory applications; however, such texture formation requires superlattices with delicately balanced boundary conditions to form. Here it is found that these textures can form in free-standing CuInP₂S₆, and that mechanical force can generate high-density domains.

Understanding drug targets and their effects in living cells is challenging. Here, the authors develop SICFA, a label-free proteomics method that sensitively detects drug-induced protein stability changes, thereby identifying targets and downstream pathways directly in living cells.

This study introduces Ni-doped W₁₈O₄₉ nanowires that integrate low-coordinated W and Ni dual active sites with surface plasmon resonance, facilitating solar-driven methanol dehydration for efficient dimethyl ether generation.

Organic batteries are promising for sustainable energy storage but face challenges in performance and cost. Here, authors develop pressurized organic electrodes with high capacity and durability under practical and extreme conditions, advancing organic batteries toward real-world applications.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Achieving complete coverage of 2-4 μm pyramids on industrial fully-textured silicon with solution processed perovskite film remains challenging. Here, authors spray-coat alumina particles on silicon for near-conformal deposition of perovskites, achieving efficiency of 32.74% for tandem solar cells.

Cesium lead iodide inorganic perovskite solar cells have great potential but the phase instability hinders their development. Here Wang et al. show a controlled drying process to make phase stable and highly efficient solar cells with power conversion efficiency of 15.7%.

The alignment of carbon nanotubes on a surface is of importance to deploy them in electronic devices. Here, Chen et al.achieve the orientation of carbon nanotubes according to their helical angle and handedness, thus separating nanotubes of different electronic properties.

The existence of chemical medium-range order (CMRO) in high- and medium- entropy alloys remains conjectural. Here the authors show evidences of CMRO by electron diffraction spots of lattice periodicity, observable entities, occupancy of preferential species, and stable sizes upon deformation.

Cryo-electron microscopy structures of the human sweet taste receptor in the apo and sucralose-bound states reveal its heterodimeric architecture and mechanisms of ligand binding and signal activation.

In this work, authors report on SCIMP-positive exosomes secreted by macrophages, that play a crucial anti-inflammatory role in pneumonia. Exosomal SCIMP primarily achieves bacterial clearance by the SCIMP-FPRs-neutrophils chemotaxis.

Here the authors construct an artificial pathogen cell with tunable rigidity and find crosstalk between these and macrophages. Macrophages probe the artificial pathogen surface, and increasing rigidity of the artificial pathogen promotes proinflammatory polarization of macrophages.

LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle changes in LC-MS status in large-scale quantitative proteomics experiments. They further prioritized 15 QC metrics and developed an AI model, implemented in a free software called iDIA-QC, for detecting LC-MS faults.

The systematic ferroelectric domain control in ferroelectric CuInP₂S₆ systems has remained elusive. Herein, the authors report the efficient ferroelectric domain engineering under a unipolar electric field in CuIn₂S₆ system.

Artificial intelligence (AI) is becoming increasingly relevant to assist with oncology imaging, but diagnosing rare tumours remains challenging. Here, the authors develop an AI approach to detect rare thyroid cancer subtypes by integrating clinical knowledge with image generation based on ultrasound imaging data from large patient cohorts.

A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

The proposed vibrating EMNPs (enteric-coated magnetic nanoparticles) treatment can effectively accelerate intestinal peristalsis, reduce the absorption, especially to water-soluble molecule. It has effects both on weight-loss and alcohol-detoxification. 3D-printed device can provide a tunable magnetic power resulting tailored effect of weight-loss.

Chimeric Antigen Receptor (CAR)-T cells show suboptimal efficacy in Acute Myeloid Leukaemia (AML). Here, the authors show that overexpression of C-JUN improves CAR-T cells efficacy in preclinical models for AML and report preliminary results of a pilot phase I clinical trial.

Polymer electrolytes are promising but are limited by narrow electrochemical window. Here, authors develop a family of in situ polymerized gel electrolytes with long term stability up to 5.0 V and develop a non-destructive life extension strategy through freezing the cells.

Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations.

Protective immunity against SARS-CoV-2 relies on both antibodies and a T cell dependent response, however, direct experimental evidence for the contribution of cellular immunity is limited. Here authors present a mouse model that is susceptible to SARS-CoV-2 and lacks B cells to demonstrate the emergence of efficient cellular immune response against SARS-CoV-2 upon vaccination or viral challenge.

Culturing adult stem cell-derived organoids requires a balance between stem cell self-renewal and differentiation, but this can be challenging to accomplish. Here, the authors present an optimized method for growing human intestinal organoids that achieve both rapid growth and diverse cell populations in a single culture system.

Rapid activation of SnRK2 kinases is central to plant responses to osmotic stress and abscisic acid. Here the authors show that a group of Raf-like kinases are very quickly activated by osmotic stress, and then phosphorylate and activate SnRK2s.

Typically nanofibres need to be placed on solid substrates for the next generation of devices, but this prevents light guiding. Here Wanget al. numerically and experimentally demonstrate that when a nanofibre is placed on a dielectric multilayer, it supports a Bloch surface wave confined in one dimension.

Biosynthesis of aromatic esters is challenged by unclear natural pathways and low efficiency. This study presents a bacterial platform for efficient production, using systematic engineering strategies including enzyme identification, reshaping enzyme tunnels and automating cellular resource allocation to enhance output.

The heterogeneous and compartmentalized environments within living cells make it difficult to deploy theranostic agents with precise spatiotemporal accuracy. Zhao et al. demonstrate a DNA framework state machine that can switch among multiple structural states according to the temporal sequence of molecular cues, enabling temporally controlled CRISPR–Cas9 targeting in living mammalian cells.

Identification of genetic determinants is pivotal for improving microbial biosynthesis of desired products. Here, the authors employ genome-scale CRISPRi modulation combining fluorescence-activated cell sorting for genome-scale target identification for overproduction of free fatty acids in E. coli.

The authors report a flexible thermoelectric film, comprising Ag₂Se and reduced graphene oxide, achieving a power factor of 37 μW cm⁻¹ K⁻² in the film and a normalized power density of over 9.8 μW cm⁻² K⁻² in the out-of-plane device.

Xiaolei Liu, Yayan Feng, et al. report an annotated draft reference genome of the non-encapsulated Trichinella pseudospiralis, and perform comparative multi-omics analyses with encapsulated T. spiralis. Overexpression of TP12446, a key excretory/secretory gene, in a mouse C2C12 skeletal muscle cell line could induce inhibition of myotube formation and differentiation. These results provide insight into the mechanism of nurse cell formation and immunoevasion, as well as the identification of potential pharmacological and diagnostic targets for trichinellosis.

The authors find that the Cu ion migration pathways determine the conductive mechanism of van der Waals ferroelectric CuInP₂S₆. By tailoring the electric field, they manipulate Cu ions transport within and between layers, revealing the transition from ferroelectric to ionic switching mechanisms.

Tetrahedral DNA framework-enabled bulk enzyme heterojunctions have been used to program biosensor interfaces. Here, the authors use DNA tetrahedrons to tether enzymes of an enzymatic cascade to gold electrodes, hence raising them over the bulk solution, which led to improved kinetics and sensitivity.