Search

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The study demonstrated that some exogenous natural polysaccharides could be absorbed in plasma with little degradation after orally administration. Polysaccharide uptake in the intestinal cells relied on clathrin/dynamin 1/Rab5-dependent endocytosis.

Macrolactones exhibit distinct conformational and configurational properties and are widely found in natural products but catalysts to govern both macrolactone formation and stereochemical control remain largely unexplored. Here, the authors disclose an N-heterocyclic carbene (NHC)-catalyzed enantioselective synthesis of chiral macrolactones varying in ring size from sixteen to twenty members that feature distinct configurationally stable planar stereogenicity.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Stereodivergent catalysis was previously limited to two possible states per stereogenic element. Now, it is demonstrated that stereoselective catalysis is capable of governing higher-order stereogenicity and the catalyst-controlled synthesis of four of the six possible stereoisomers arising from a single stereogenic unit is showcased.

Interleukin-1β (IL-1β) is a proinflammatory factor related to cancer progression that is synthesized as a precursor named pro-interleukin-1β (Pro-IL-1β). Here, the authors discover that Pro-IL-1β presents a IL-1β-independent pro-metastatic function through RACK1 regulation and modulation of actin cytoskeleton remodeling.

A telomere-to-telomere genome assembly of the elite Gossypium hirsutum variety ZM113 provides insights into upland cotton short-season adaptation and identifies a repositioned, satellite repeat-rich centromere.

Based on the correlation analysis of various omics data from Brassica napus L., authors identify one Flavobacterium strain C2 which mitigates P deficiency by regulating fatty acid metabolism and enhancing P uptake, indicating potential strategies to improve P utilization in rapeseeds.

A cluster randomized trial in China shows that telemedicine-based, village doctor-led delivery of integrated care reduced the occurrence of adverse cardiovascular events and hospitalizations in older adults with atrial fibrillation.

Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage.

Aldol condensation is an important reaction in polymer synthesis, but due to the lack of reliable analytical methods, direct evidence of the polymer microstructure and sequence has remained elusive. Here, the authors combine electrospray deposition and scanning tunnelling microscopy to image four n-type polymers at sub-monomer resolution, revealing and quantifying unexpected structural defects intrinsic to the aldol condensation process.

Despite the large theoretical promise of Li metal anode, the dendrite growth poses a serious safety challenge. Here the authors address this issue by adding octaphenyl polyoxyethylene as an electrolyte additive which facilitates the formation of a dual-functional layer and excellent performance.

Cloning quantitative trait loci (QTL) in crops is often slow and laborious. Here, the authors describe RapMap, a method to rapidly clone multiple QTL based on F₂ gradient populations coupled with a co-segregation standard, and show how it can be used to identify genes controlling grain size in rice.

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

A dual-site catalyst consisting of Cu nanoparticles (NPs) and atomic Cu sites is designed. The atomic Cu boosts H2O dissociation for modulating the *H coverage on Cu NPs, improving the efficiency of CO2 electroreduction to multi-carbon products.

Rag-GTPases play roles in sensing nutrient availability, and it is not fully known how they contribute to energy-consuming immunological processes such as the B cell response. Here authors show that genomic deletion fo RagA/RagB distrupts both T-dependent and T-independent humoral immune responses, independent of mechanistic target of rapamycin complex 1 but involving the transcription factors TFEB and TFE3.

Nitrogen oxides are vital in the nitrogen cycle and renewable chemical synthesis, but selective conversion to multi-nitrogen products via precise N-N bond formation is challenging. Here, the authors report a two-step electrochemical process that achieves an impressive 88.7% selectivity for hydrazine production using a WO₃ catalyst with diphenyl ketone as a mediator.

Inspired by the swift swingable abdomen, conducting canals, and body setae of Stenus comma, the authors present a swift, agile untethered insect-scale soft propulsor, offering new insights into systematically bio-inspired artificial soft robots.

Efficient electroreduction of CO2 to multi-carbon products under strong acidic condition is highly challenging. Here, the authors demonstrate that combining microenvironment modulation and La doping effect could promote multicarbon products generation in acidic electrolyte.

Noble-metal-free catalysts often show stability issues in acidic media due to structural degradation. Here authors show that phase-mixed engineering of cobalt diselenide electrocatalysts can enable greater covalency of Co-Se bonds and improve robustness for catalyzing hydrogen evolution in acid.