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The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Polyene is a segment of polyacetylene, a conductive polymer. Here, the authors measured the conductance of single molecular chain of trans-polyene and found a high conductivity and low decay constant, attributed to the alignment of the energy levels.

Methods for direct incorporation of tri- and di-fluoroethanol units in molecules are relatively limited. Here, the authors report two organosilicon reagents which are applied to allylation, alkylation and alkenylation reactions as tri- and di-fluoroethanol transfer reagents.

Thermogenic proteins like PGC1α are downregulated under thermal stress, but the underlying mechanisms are unclear. Here, the authors show that chaperone-mediated autophagy, regulated by PARK7, controls PGC1α stability and BAT function at thermoneutrality.

PINK1/Parkin-mediated ubiquitin-dependent mitophagy is a key regulator of browning in inguinal white adipose tissue (iWAT). Here, the authors report that PNPLA7, an Endoplasmic Reticulum and mitochondria-associated membrane (MAM) protein, inhibits browning of iWAT by promoting PINK1/Parkin-mediated mitophagy upon cold challenge or adrenergic receptor agonist treatment.

Domestic wastewater effluents contribute at least 3.1% of dissolved carbon in global rivers, highlighting a need to incorporate the legacy carbon into global carbon budget assessment, as well as to monitor and reduce carbon in wastewaters.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Zhang, Xu, Liu, Wang et al. identify an inhibitory mechanism for RIPK1 kinase through EGLN1/pVHL-mediated proline hydroxylation, which is disrupted upon prolonged hypoxia that activates RIPK1 activity to promote cell death and inflammation.

Arachnoid cuff exit points create openings in the arachnoid barrier enabling the drainage of cerebrospinal fluid and exchange of molecules and cells between the dura and the subarachnoid space, therefore physically connecting the brain and the dura.

Zhong et al. find that SERRATE (SE) regulates the m⁶A methyltransferase complex (MTC) to control m⁶A deposition, and show cross-regulation between the MTC and the SE-mediated microprocessor governs miRNA production in Arabidopsis.

Single-molecule electrical detections clarify both productive and hidden degenerate pathways of ring-closing metathesis, and enable precise on-device synthesis of a single polymer with single-monomer-insertion-event resolution.

Based on the correlation analysis of various omics data from Brassica napus L., authors identify one Flavobacterium strain C2 which mitigates P deficiency by regulating fatty acid metabolism and enhancing P uptake, indicating potential strategies to improve P utilization in rapeseeds.

Cloning quantitative trait loci (QTL) in crops is often slow and laborious. Here, the authors describe RapMap, a method to rapidly clone multiple QTL based on F₂ gradient populations coupled with a co-segregation standard, and show how it can be used to identify genes controlling grain size in rice.

RNA secondary structure is a new regulatory layer of transcript fates. Here, Li et al. find that plant RNA helicase Brr2a, acting beyond its canonical role in spliceosome, can optimize secondary structure of pri-miRNAs to promote miRNA production.

Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage.

Parallel degradome sequencing and DMS-MaPseq pinpoint the first cleavage sites on bona fide pri-miRNAs, decode their in vivo structure and provide better interpretation of the cleavage modes and impact of DCL1 cofactors in the process in Arabidopsis.

Ye and colleagues show that an oncolytic virus that delivers tumor-irrelevant bystander T cell epitopes to tumor cells can exploit the abundant population of bystander T cells in the tumor for anti-tumor immunity and potentiate cancer immunotherapy.

Inspired by the swift swingable abdomen, conducting canals, and body setae of Stenus comma, the authors present a swift, agile untethered insect-scale soft propulsor, offering new insights into systematically bio-inspired artificial soft robots.

While platinum is a highly active catalyst for H₂ evolution, its low abundance prompts research into earth-abundant alternatives. Here, authors prepare tungsten atomic clusters on phosphorus doped carbon by thermal migration and demonstrate excellent activities for hydrogen evolution electrocatalysis.

A dual-site catalyst consisting of Cu nanoparticles (NPs) and atomic Cu sites is designed. The atomic Cu boosts H2O dissociation for modulating the *H coverage on Cu NPs, improving the efficiency of CO2 electroreduction to multi-carbon products.

Multi-component cascade transformations including difunctionalization of two alkynes with both syn- and anti-selectivity in one catalyst system is challenging. Herein, the authors report a Nickel-catalyzed four-component reaction to access densely substituted 1,3-dienes using two terminal alkynes, aryl boroxines, and perfluoroalkyl iodides.

Orbital forcing consistently influenced the magnitude of millennial-scale climate variability through the Pleistocene, according to an analysis of four high-resolution Northern Hemisphere proxy records covering the past 1.5 Myr.

The lack of efficient and cost-effective catalysts for hydrogen oxidation reaction (HOR) hampers the application of hydroxide exchange membrane fuel cells. Here, authors reported bimetallic MoNi₄ and WNi₄ nanoalloys with marked HOR activity in alkali, among which MoNi4 outperforms the Pt/C catalyst.

Noble-metal-free catalysts often show stability issues in acidic media due to structural degradation. Here authors show that phase-mixed engineering of cobalt diselenide electrocatalysts can enable greater covalency of Co-Se bonds and improve robustness for catalyzing hydrogen evolution in acid.

Stem cell factor (SCF) and its receptor, Kit, have known roles in regulating cell growth and survival. Here, Huang et al. reveal a new function of SCF/Kit signalling, showing that it increases energy expenditure and mitochondrial function in brown adipose tissue by promoting expression of PGC-1a.

UVB light photoreceptor UVR8 physically interacts with WRKY36 in nuclei. WRKY36 promotes hypocotyl elongation by inhibiting HY5 transcription. UVR8 inhibits WRKY36 binding to the HY5 promoter.