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Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

NPM3 promotes histone lactylation (H3K18la/K27la) and drives FASN transcription and cardiomyocyte necroptosis in diabetic cardiomyopathy. Targeting this pathway with dihydroartemisinin alleviates cardiac dysfunction.

Interfacial charge recombination losses limit solar cell efficiency. Gao et al. mitigate these losses through front and rear-contact engineering, achieving efficiencies of 26.34% and 32.73% in tunnel oxide passivating contact single-junction and tandem solar cells.

Liu, Tao, et al. share a Phase 4 randomized in which nearly 500 women undergoing hysteroscopic surgery received either oliceridine or a standard opioid in combination with propofol sedation, with continuous monitoring of respiratory and recovery parameters. Patients receiving oliceridine experienced fewer episodes of intraoperative hypoxia, required less propofol, and reported higher satisfaction, as did surgeons.

Yang, Zeng et al. investigate associations between maternal metabolic profiles during early pregnancy and offspring development using untargeted metabolomics in the Shanghai Birth Cohort. Several metabolites are associated with offspring birth weight and cognitive development in childhood and reflect sex-specific patterns.

Crystallizing the perovskite layer on thin tunnel oxide passivated contact silicon cells is challenging due to rapid heat transfer. Zhou et al. address this issue using a 2-mercaptobenzothiazole additive, achieving a tandem cell efficiency of 32.76%.

This study reveals that the rice false smut fungus disrupts floret development and suppresses immunity by secreting the effector Sxp1, which targets a lipid transfer protein and interferes with lipid signalling required for pollen fertility and immune responses.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

Efficiency loss in thick film organic solar cells is a bottleneck for scalable manufacturing. Here, the authors present an exciton spin-manipulation strategy to extend exciton diffusion length and reduce non-radiative recombination losses.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease diagnosis.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

In the presence of a sufficient magnetic field, magnetofluids can resist high-speed blood flow, offering a personalized and complete strategy for left atrial appendage occlusion.

In this study, the authors identify two biologically distinct subtypes of adolescent major depressive disorder by analyzing interactions between sensory and higher-order association brain regions, offering new insights for the development of targeted diagnostic and therapeutic approaches.

Achieving multiple functions in a self-sustained human-machine interface remains challenging. Bai et al. show a hydrogel-based e-skin that integrates thermogalvanic, piezoionic, and diffusion mechanisms for self-powered simultaneous sensing of skin temperature, arterial pulsation, and sweat secretion.

Tunnel oxide passivating contact silicon solar cells are a promising next-generation photovoltaic technology. Yang et al. engineer the front and back contact, further increasing the power conversion efficiency to 26.66%.

The authors developed self-incompatible diploid potatoes via haploid breeding. The resulting F₁ hybrids prevent fruit set, redirect photoassimilates to tubers, increase the harvest index and enable scalable hybrid seed production.

Existing nickel-catalysed enantioconvergent cross-coupling methods largely rely on Ni(I)/Ni(III) manifolds. Now, a mechanistically distinct platform involving a Ni(II)/Ni(IV) redox cycle enables highly enantioselective difluoromethylation of unactivated alkyl iodides.

Flying cars integrate ground-vehicle mobility with aircraft capabilities, making them candidates for deployment in the low-altitude economy and emergency rescue. We have advanced three enabling technologies — morphology design, multi-modal fusion perception, and active safety — across four generations of flying-car platforms.

A lab-scale proof-of-principle demonstration of a quantum network comprising one server chip and 20 client photonic chips implementing twin-field quantum key distribution shows excellent scalability and reliability and yields a pathway towards future large-scale networks.

The light-driven enzyme catalytic systems composed of NAD(P)H regeneration and NAD(P)H-dependent enzymatic process emerge as biomanufacturing platforms for the synthesis of value-added chemicals. Here, the authors present a photo-enzyme-membrane catalytic system coupled with multi-enzyme cascade for ethylene glycol synthesis.

Uneven urbanization in China leaves strong legacy effects on urban bird communities, creating widespread extinction debts and colonization credits across taxonomic, functional and phylogenetic diversity. Historical vegetation and human pressures shape these lags, mediated by species’ life-history traits.

Light-dependent phosphorylation can modulate rice blast immunity. Here the authors show that the receptor-like kinase OsLIKE1 phosphorylates LHCB5 to confer blast resistance and identify SNPs that could potentially be used to breed resistant cultivars.

Liu, Liu, Wu and Yao et al. developed a peptide inhibitor that selectively blocks the Ada-two-A-containing histone complex by targeting the YEATS2 YEATS domain and suppresses tumor growth in non-small cell lung cancer.

Pancreatic ductal adenocarcinoma (PDAC) shows immunotherapy resistance and has limited treatment options. Here the authors show that arachidonic acid, a ω-6 polyunsaturated fatty acid, can induce pyroptosis and enhace anti-PD-1 therapy in an immunocompetent PDAC model.

N input and warming alter plant traits and mycorrhizal communities, reducing belowground C inputs and stable soil organic C while accelerating decomposition, highlighting root–mycorrhizal interactions as key regulators of soil C under global change.

The efficient low-temperature combustion of stable alkanes remains a major challenge in catalysis. Now it has been shown that a Pt–Nb dual-atom catalyst enables propane combustion through a distinct stepwise-boosting, current-assisted atomic relay mechanism, yielding complete conversion below 200 °C and a high turnover frequency.

Peng et al. identify a class of non-aromatic, chorismate-derived compounds, abundant in the roots of Arabidopsis thaliana. These compounds are made by a biosynthetic gene cluster comprising five adjacent genes encoding biosynthetic enzymes.

This study shows that WDR5 remodels NANOG condensates to control transcriptional programs. Disrupting their interaction compromises stem cell identity and suppresses leukemia stem cell expansion.

The efficient mass transport is the key factor to advancing the flow-electrocatalytic chemosynthesis. Here, the authors design a flow-through architecture in flow electrolyzer, reinforcing mass transport in the electrolyte to achieve the high efficiency of continuous oxime electrosynthesis.

CrPS₄, a 2D van der Waals A-type antiferromagnet, is shown to exhibit ideal characteristics of Stoner–Wohlfarth antiferromagnets, such as ferromagnet-like binary switching rather than layer-by-layer flipping as in other 2D A-type antiferromagnets.

Current batteries face performance limits due to structural flaws of electrode materials. Here, authors report a layered negative electrode material design that enhances ion transport and stability to deliver high capacity and long life with nearly zero-strain evolution across a wide range of temperatures.

A smartphone-controlled ingestible capsule can have a two-way communication with engineered microbes inside the gut via light-induced signals.

One challenge for spin-based electronics is the controlled and reliable switching of magnetization without magnetic fields. Here, Liu et al investigate a variety of compositions of CoPt, and determine the specific composition to maximize switching performance, potentially simplifying device design.