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Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

Liquid water or moisture discharge is a significant source of energy waste in current single-stage water-enabled electric generators. Here, authors propose a modular multistage coupling device that integrates internal liquid water flow and subsequently generated moisture to optimize energy harvesting at all stages.

A catalogue of nucleotide-binding leucine-rich repeat (NLR) genes in wild and cultivated potato genomes enables the identification of genes that confer protection against late blight, and provides a transgene-free strategy for engineering disease resistance in potato.

p53-binding protein 1 (53BP1) is a component of the DNA double-strand break signaling and repair. Here the authors show that that loss of 53BP1 in cancer cells leads to cGAS/STING pathway activation and anti-tumor immune responses in ovarian and pancreatic cancer models.

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

WHaloCaMP is a chemigenetic calcium indicator that can be combined with different rhodamine dyes for multiplexed or FLIM imaging in vivo, as demonstrated for calcium imaging in neuronal cultures, brain slices, Drosophila, zebrafish larvae and the mouse brain.

In this study, the authors develop a potent bispecific antibody targeting two epitopes within the SARS-CoV-2 receptor binding domain and showing robust prophylactic and therapeutic efficacy against XBB.1 infection in mice.

BiKE-secreting CAR-T cells and NK cells combine to suppress tumours in mouse models.

The synthesis of covalent organic frameworks with a multiple-dynamic-bonds strategy realizes selective extraction of uranyl tricarbonate anions from ultra-low concentrations and multiple interfering ions.

Mobility impairment reduces autonomy and social participation. Here, the authors discuss how wearable technologies are transforming assisted mobility towards more adaptive, intuitive, and user-centered solutions.

Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.

Developing high-performance potassium-ion batteries remains a challenge. Here, the authors show that few-layered Sb₂S₃/carbon composite anode synthesized via simple exfoliation minimizes the volume changes during (de)intercalation of K⁺ ions with boosted rate performance and cyclability.

Saturation genome editing characterizes BAP1 variants and their association with disease presentation. A phenome-wide association analysis in the UK finds that BAP1 variants identified as deleterious in the study are associated with higher serum IGF-1 levels.

Single-cell analyses of immune cells from patients with pathogenic, single large-scale mitochondrial DNA (mtDNA) deletions including Pearson syndrome describe heteroplasmy dynamics consistent with purifying selection, as well as T-cell state-specific regulatory mechanisms and metabolic vulnerabilities.

Arabidopsis EH/Pan1 proteins are part of the TPLATE complex (TPC) that is required for endocytosis in plants. Here, the authors show AtEH/Pan1 proteins also act in actin-mediated autophagy, by interacting with VAP27-1 at ER-PM contact sites and recruiting TPLATE and AP-2 complex subunits, clathrin and ARP2/3/ proteins to autophagosomes.

VERNALIZATION INSENSITIVE 3-LIKE 1 regulates intercellular communication during the growth transition after bulb dormancy by epigenetic regulation of callose synthase via the NF-YA7 transcription factor.

Guidelines for fine-tuning spectral and chemical properties of fluorophore are introduced, resulting in four new Janelia Fluor dyes, JF₅₀₃, JF₅₂₅, JF₅₈₅ and JF₆₃₅, that span the visible region and align well with standard laser lines.

The role of social resilience in mitigating hunger related to climate change is explored in North Korea, South Korea and China, regions with similar climatic conditions but varying levels of economic development.

Characterization of 22-nucleotide short interfering RNAs in plants finds that they accumulate in response to environmental stress, causing translational repression, inhibition of plant growth and enhanced stress responses.

A collection of improved FRET-based calcium biosensors, called Twitch sensors, is described. Twitches have a reduced number of calcium binding sites per sensor and display high sensitivity in in vivo imaging experiments in mouse brain and lymph node.

Genetically encoded voltage indicators (GEVIs) allow visualisation of fast action potentials in neurons but most are bright at rest and dimmer during an action potential. Here, the authors engineer electrochromic FRET GEVIs with fast, bright and positive-going fluorescence signals for in vivo imaging.

Functional and structural studies of two potent antibodies isolated from individuals exposed only to ancestral SARS-CoV-2, demonstrating broad neutralization against the latest SARS-CoV-2 variants and related sarbecoviruses.

The authors built a simple optical module that generates axially extended Bessel foci, optimized for in vivo brain imaging. Easily incorporated into existing two-photon fluorescence microscopes, this module allowed 30-Hz volumetric functional imaging of sparsely labeled brains at synaptic resolution in a variety of model organisms in vivo.

This study presents 11 telomere-to-telomere genomes of wild and domesticated pepper, highlights how transposable elements have shaped the evolution of genome structure and regulatory elements and identifies structural variations and introgressions associated with key traits in cultivated pepper.

In Arabidopsis thaliana, pathogen-secreted proteases trigger a previously unknown defence response involving heterotrimeric G-protein complexes upstream of a mitogen-activated protein kinase cascade.

Research on Arabidopsis indicates that RNA decay, PTGS pathway, GC content, and spatial-temporal gene expression impact ct-siRNA production, vital for gene silencing during plant growth and stress responses.

Often in the process of aging it is seen that genes and proteins providing normal physiological function at younger ages are detrimental in older age. VIMAR/RAP1GDS1 expression is one such factor with age-dependent functional duality in fly and mouse models.