Nature Search

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis

Atopic dermatitis is an immune disease driven by cytokines including IL-4/IL-13. This study shows that a topical ITK/TRK inhibitor blocks an array of T cell cytokines, inhibits NGF-induced basophil activation, and reduces inflammation in human skin explants and dermatitis models, indicating therapeutic potential.

Jennifer L. Duffen
Kimberly K. Crouse
Michael J. Primiano
ResearchOpen Access09 Mar 2026
Nature Communications

P: 1-16
Water mass specific genes dominate the Southern Ocean microbiome

Southern Ocean microbial communities are less well studied. Here, the authors generate a circumpolar-scale gene catalog from 218 metagenomics samples revealing broadscale uniqueness and water-mass–specific adaptations of the Southern Ocean microbiome.

Emile Faure
Jolann Pommellec
Loïs Maignien
ResearchOpen Access09 Mar 2026
Nature Communications

Volume: 17, P: 1-16
Spin-exciton coupling modified by interfacial magnetic interactions in a van der Waals heterostructure

Excitons are important excitations in solids with potential applications in quantum and spintronic technologies. The authors achieve bidirectional control of exciton energy in a twodimensional antiferromagnetic semiconductor via interfacial spin-exciton coupling.

Weican Lan
Chaocheng Liu
Wensheng Yan
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-10
Modality-projection universal model for comprehensive full-body medical imaging segmentation

Applying universal AI models across multiple modalities remains challenging. Here, the authors present a model that enables multi-modality whole-body segmentation for computer-aided diagnosis, revealing metabolic correlations across brain, body, and brain–body systems.

Yixin Chen
Lin Gao
Zhaoheng Xie
ResearchOpen Access24 Oct 2025
Nature Communications

Volume: 16, P: 1-14
A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA

A fungal dioxygenase CcTet displays robust demethylation activity against both N⁶-methyladenosine (6mA) and 5-methylcytosine on duplex DNA, while its D337F mutant exhibits specific activity against 6mA, providing a useful tool for 6mA functional study.

Yajuan Mu
Lin Zhang
Liang Zhang
Research02 Jun 2022
Nature Chemical Biology

Volume: 18, P: 733-741
PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate

How metabolic signals are sensed by the cell cycle machinery remains unclear. Here, the authors demonstrate that the glycolytic enzyme PFKM acts as a citrate sensor to promote mitosis, coupling metabolic activity to cell cycle regulation.

Pianpian Lin
Yijun Qi
Weiwei Yang
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Amy R. Bentley
Yun J. Sung
L. Adrienne Cupples
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 636-648
Decline in plankton diversity and carbon flux with reduced sea ice extent along the Western Antarctic Peninsula

Over the past century, the Western Antarctic Peninsula has experienced rapid warming and a substantial loss of sea ice with important implications for plankton biodiversity and carbon cycling. Using a 5-year DNA metabarcoding dataset, this study assesses how interannual variability in sea-ice conditions impacts biodiversity and biological carbon fluxes in this region.

Yajuan Lin
Carly Moreno
Nicolas Cassar
ResearchOpen Access16 Aug 2021
Nature Communications

Volume: 12, P: 1-9
Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity

Yingze Li
Mengge Zheng
Yu Cheng
ResearchOpen Access03 Feb 2026
Cell Research

Volume: 36, P: 197-218
Ca²⁺ transients on the T cell surface trigger rapid integrin activation in a timescale of seconds

Lymphocytes need to be slowed down rapidly to enter tissues. Here the authors characterise the arrest of lymphocytes and using a calcium biosensor propose that a rapid drop in extracellular calcium concentration results in integrin activation and lymphocyte arrest.

Yue Li
ShiHui Wang
JianFeng Chen
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Multicolor Colormetric Biosensor for the Determination of Glucose based on the Etching of Gold Nanorods

Yue Lin
Mengmeng Zhao
Zhenyu Lin
ResearchOpen Access25 Nov 2016
Scientific Reports

Volume: 6, P: 1-7
Dysfunction in sensorimotor and default mode networks in major depressive disorder with insights from global brain connectivity

Using a large multisite dataset of people with major depressive disorder and healthy controls, the authors show global brain connectivity alterations in the sensorimotor, visual, and default mode networks.

Yajuan Zhang
Chu-Chung Huang
Chun-Yi Zac Lo
Research26 Sept 2024
Nature Mental Health

Volume: 2, P: 1371-1381
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin

Zhang et al. report that the lncRNA H19 stabilizes dystrophin by competing with the ubiquitin E3 ligase TRIM63 for association with dystrophin, thereby alleviating muscular dystrophies.

Yaohua Zhang
Yajuan Li
Liuqing Yang
Research26 Oct 2020
Nature Cell Biology

Volume: 22, P: 1332-1345
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules. Yang et al. report triple-negative tumor cell expression of the lncRNA LINK-A enhances degradation of antigen peptide-loading complex molecules and intrinsic tumor suppressors, which contribute to tumor persistence.

Qingsong Hu
Youqiong Ye
Liuqing Yang
Research03 Jun 2019
Nature Immunology

Volume: 20, P: 835-851
Discovery and small RNA profile of Pecan mosaic-associated virus, a novel potyvirus of pecan trees

Xiu Su
Shuai Fu
Xueping Zhou
ResearchOpen Access26 May 2016
Scientific Reports

Volume: 6, P: 1-7
Metagenome-wide association of gut microbiome features for schizophrenia

Gut microbiome has been linked to neurogenerative diseases. Here, the authors present a metagenome-wide association study of schizophrenia (SZ) in human cohorts and identify SZ-associated specific gut-brain functional modules and pathways including SCFAs and neurotransmitters.

Feng Zhu
Yanmei Ju
Xiancang Ma
ResearchOpen Access31 Mar 2020
Nature Communications

Volume: 11, P: 1-10
Explore the role of CBS in stomach adenocarcinoma based on the sulfur-containing amino acid metabolism network

Ping Zhang
Yingchao Liu
Jun Xia
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-18
Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

Snail1 is a key factor controlling epithelial-to-mesenchymal transition and cancer metastasis. While the E3 ligases responsible for Snail1 ubiquitination and degradation have been defined, the deubiquitinating enzyme is unknown. Here Zhou and colleagues show that Dub3 stabilizes Snail1 by removing ubiquitin, thus impacting breast cancer cell metastasis.

Yadi Wu
Yu Wang
Binhua P. Zhou
ResearchOpen Access15 Feb 2017
Nature Communications

Volume: 8, P: 1-16
TNF-α modulation by rice bran peptides: implications for gut microbiota stability and cognitive health in aging

Jianfei Mu
Qinlu Lin
Ying Liang
ResearchOpen Access09 Oct 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-17
Deep learning for predicting 16S rRNA gene copy number

Jiazheng Miao
Tianlai Chen
Yajuan Lin
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia

Dong Liu
Yajuan Xu
Pengkun Lin
ResearchOpen Access04 Apr 2025
Scientific Reports

Volume: 15, P: 1-8
Integrin αEβ7⁺ T cells direct intestinal stem cell fate decisions via adhesion signaling

Shiyang Chen
Yajuan Zheng
Jianfeng Chen
Research13 Sept 2021
Cell Research

Volume: 31, P: 1291-1307
Regulating the metabolic flux of pyruvate dehydrogenase bypass to enhance lipid production in Saccharomyces cerevisiae

The carbon flux rearrangement based on PDH bypass enhances the accumulation of acetyl-CoA and promotes the synthesis of lipid compounds downstream in Saccharomyces cerevisiae.

Cairong Lei
Xiaopeng Guo
Dong Lu
ResearchOpen Access26 Oct 2024
Communications Biology

Volume: 7, P: 1-13
Specific eukaryotic plankton are good predictors of net community production in the Western Antarctic Peninsula

Yajuan Lin
Nicolas Cassar
Zuchuan Li
ResearchOpen Access01 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Evidence of limited N₂ fixation in the Southern Ocean

Low levels of nitrogen fixation may be occurring in the Southern Ocean, according to in-situ measurements of seawater from the western Antarctic Peninsula and Palmer Station

Shuai Gu
Hugo Berthelot
Nicolas Cassar
ResearchOpen Access05 Apr 2025
Communications Earth & Environment

Volume: 6, P: 1-9
LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Qingsong Hu
Chunlai Li
Liuqing Yang
Research10 Jan 2019
Cell Research

Volume: 29, P: 286-304
Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia

Jiajia Zhao
Chu-Chung Huang
Chun-Yi Zac Lo
ResearchOpen Access21 Jun 2023
Translational Psychiatry

Volume: 13, P: 1-8
Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3

Cui Liu
JunLei Wang
JianFeng Chen
Research19 Jul 2022
Oncogene

Volume: 41, P: 4091-4103
Linking patterns of net community production and marine microbial community structure in the western North Atlantic

Seaver Wang
Yajuan Lin
Nicolas Cassar
Research22 Jun 2018
The ISME Journal

Volume: 12, P: 2582-2595
Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice

Feng Zhu
Ruijin Guo
Xiancang Ma
Research07 Aug 2019
Molecular Psychiatry

Volume: 25, P: 2905-2918
Contrasting diel hysteresis between soil autotrophic and heterotrophic respiration in a desert ecosystem under different rainfall scenarios

Weimin Song
Shiping Chen
Guanghui Lin
ResearchOpen Access30 Nov 2015
Scientific Reports

Volume: 5, P: 1-13
GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1

Shuyu Guo
Yuxin Zhang
Lin Wang
ResearchOpen Access09 Mar 2018
Cell Death & Differentiation

Volume: 25, P: 1996-2009
Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3

Shuyu Guo
Yuxin Zhang
Junqing Ma
ResearchOpen Access08 May 2017
Scientific Reports

Volume: 7, P: 1-12
RBC transfusion and necrotizing enterocolitis in very preterm infants: a multicenter observational study

Dan Dang
Xinyue Gu
Joseph Ting
ResearchOpen Access21 Jun 2024
Scientific Reports

Volume: 14, P: 1-8
Niche partitioning and biogeography of high light adapted Prochlorococcus across taxonomic ranks in the North Pacific

Alyse A Larkin
Sara K Blinebry
Zackary I Johnson
Research22 Jan 2016
The ISME Journal

Volume: 10, P: 1555-1567
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14^ARF degradation

Pingzhao Zhang
Kun Gao
Chenji Wang
Research06 Nov 2021
Cell Death & Differentiation

Volume: 29, P: 758-771
A perspective for adapting generalist AI to specialized medical AI applications and their challenges

Zifeng Wang
Hanyin Wang
Jimeng Sun
ReviewsOpen Access11 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-13
Formaldehyde initiates memory and motor impairments under weightlessness condition

Tianhao Mei
Ying Chen
Zhiqian Tong
ReviewsOpen Access28 Oct 2024
npj Microgravity

Volume: 10, P: 1-14
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Association between the risk of necrotizing enterocolitis and intrauterine growth: a multicenter cohort study

Dan Dang
Siyuan Jiang
Joseph Ting
Research13 Jun 2025
Pediatric Research

Volume: 99, P: 703-709
Open science resources from the Tara Pacific expedition across coral reef and surface ocean ecosystems

Fabien Lombard
Guillaume Bourdin
Gaby Gorsky
ResearchOpen Access01 Jun 2023
Scientific Data

Volume: 10, P: 1-25
Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

Yajuan Li
Yuelong Li
Tengchuan Jin
ReviewsOpen Access10 Oct 2016
Cellular & Molecular Immunology

Volume: 14, P: 80-89

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