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LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genetic LINE-1 derepression is accompanied by cGAS–STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

Engineering catalyst interfaces plays a key role in designing supported metal systems. Here, the authors report that Ni nanoparticles redisperse from SiO₂ to molybdenum carbide, forming dual interfaces that enhance tandem CO₂ hydrogenation.

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, with treatment effectiveness, including immunotherapy, limited by immunosuppressive tumor microenvironment. This study identifies TNK2/ACK1 as a driver of immune evasion in pancreatic cancer via STAT5A-HVEM signaling that disables CD8⁺ T cells while TNK2 inhibition restores antitumor immunity and synergizes with anti-PD-1 and chemotherapy in PDAC models.

Cerebral palsy lacks reliable biomarkers for early and accurate diagnosis. Here, the authors show serum proteomic signatures of disease and develop a multi-biomarker diagnostic model.

Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.

Traditional cultured meat scaffolds employ animal-derived biomaterials or intricate manufacturing, but plant-based scaffolds offer an appealing alternative. Here the authors present a simple shortcut method to transform common vegetables into edible bioscaffolds via autoclaving, which mimics meat stiffness and microstructure.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

Understanding RNA regulation mechanisms is crucial for developing targeted therapies for diseases and elucidating how cells control gene expression. This study presents a physics-informed machine learning framework to investigate dynamic regulatory mechanisms in RNA complexes, which when applied to the P-TEFb/Tat/TAR system involved in HIV-1 transcriptional activation and the aaRS/tRNA system essential for genetic translation, outperforms existing methods for uncovering latent regulatory networks.

Claudin proteins maintain epithelial and endothelial tight junctions, but their functions in adipocytes lacking such junctions remain unclear. Here, the authors show that claudin-5 present in non-thermogenic adipocytes regulates thermogenesis and energy expenditure by modulating IL-10 secretion.

Achieving both high efficiency and narrow emission in organic light-emitting transistors (OLETs) remains a challenge. Here the authors demonstrate laterally integrated OLETs with an intrinsic microcavity that achieve both enhanced efficiency and narrow emission.

Salmonella is a major cause of foodborne disease worldwide. Authors created a Salmonella database and present a genetic atlas of antimicrobial resistance, identifying some socioeconomic and environmental drivers for the rise of resistance globally.

Here authors show that EVs derived from hepatocellular carcinomas may contain the long noncoding RNA, HDAC2-AS2, which suppresses antitumour CD8 + T cells by interfering with transcriptional and epigenetic regulation of their activated, cytotoxic functional state.

The authors report a catalyst featuring Rh-Zn dual sites in a MoS₂ lattice integrated with TiO₂ for the photocatalytic carbonylation of CH₄ with CO and O₂ to CH₃COOH with a high productivity of 152.0 μmol g_cat.⁻¹ h⁻¹ and selectivity of 96.5%.

Sequencing analysis of tamoxifen-associated uterine cancers and further in vivo analyses suggest that the drug tamoxifen can activate the PI3K pathway in the absence of oncogenic mutations.

CRISPR diagnostics are routinely used for the detecting nucleic acids, but rarely for clinically important proteins. Here, by translating a CRISPR-based DNA test into an ultrasensitive assay for antibodies, the authors achieve antibody detection from serum samples at attomolar concentrations.

Complicated associations between multiplexed environmental factors and aging are poorly understood. Here, authors show heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics.

N⁶-methyladenosine (m⁶A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m⁶A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m⁶A modification, decreases viral ds RNA content, and thereby dampens the RIG/MDA5-induced anti-viral immunity.

The authors study transport in the superconducting state of infinite-layer nickelate Nd_0.8Sr_0.2NiO₂ films using a Corbino-disk configuration, finding that the magnetoresistance changes from isotropic to four-fold anisotropic with increasing magnetic field. At even higher field, an additional two-fold component emerges, which coincides with an anomalous upturn of the critical field.

High-resolution electron microscopy requires robust and noise-free substrates to support the specimens. Here, the authors present a polymer- and transfer-free direct-etching method for fabrication of graphene grids with ultraclean surfaces and demonstrate cryo-EM at record high resolution.

The authors provide insights into the role of neuronal CCL2 expression, which is triggered with hyperglycaemia and modulates anxiety disorders under conditions of diabetes.

Authors find that freestanding single crystalline antiferroelectric PbZrO₃ membranes exhibit remarkable flexibility that can endure a maximum bending strain of 3.5%, with the assistance of mechanical-induced antiferroelectric-ferroelectric phase transition.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

Propane dehydrogenation is challenging to perform under mild conditions due to the reaction’s endothermic nature. Now, near-ambient propane dehydrogenation has been shown using copper single-atom catalysts supported on titanium oxide under light illumination and a water vapour environment.

Salvia miltiorrhiza is a medicinal plant that can produce the bioactive tanshinones. Here, the authors report the improved genome assembly and reveal the possible roles of three CYP71Ds in catalyzing the reactions leading to the formation of the characteristic furan D-ring of transhinones.

The authors prepare an all-organic dielectric film with a nano-submicron surface layer via electrospinning technology, achieving a simultaneous improvement in the discharged energy density and charge/discharge efficiency.

Reactivating adult cardiomyocyte proliferation is key to heart regeneration post-injury. Here, authors show that medium from human iPSC-derived primitive macrophages (hiPM-cm) induces adult cardiomyocyte proliferation and promotes heart regeneration.

Synthesizing functionalized polyethylenes via ethylene coordination copolymerization using vinyl polar monomers is challenging. Here, the authors present an approach utilizing binuclear Ni catalysis for ethylene/acrylamide copolymerization to synthesize cyano-functionalized polyethylenes.

Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.

Covalent organic frameworks are used in capture of radioactive ions but achieving high separation factors remains challenging. Here, the authors design an ionic COF its neutral non-ionic to better understand the role of different N sites on the selective capture of Th(IV) and report remarkable separation factors ranging from 10² to 10⁵.

Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.

Mesenchymal stem cells (MSC) are used for immunosuppressive therapy and a uniform source or heterogeneity characterisation is needed. Here the authors use multi-omics to compare human MSC from different sources and ages of donors and show differences in gene expression and immunosuppressive function.

Dynamic and non-volatile memristors can be used to create hardware-based reservoir and readout layers in artificial neural networks, providing a fully analogue signal processing chain for efficient data classification.

Energy stress activates AMPK leading to metabolic plasticity and therapy resistance in cancer. Here, the authors show that AMPK activation decreases Prospero-related homeobox 1 (PROX1) levels impairing branched amino acid metabolism and tumourigenesis in liver and lung cancer models.

Acute respiratory distress syndrome (ARDS) is an acute pulmonary disease involving neutrophils. Here the authors characterise lung neutrophil infiltration during ARDS and show that there are neutrophils with different function and transcriptional profile which are regulated by IL-10.

Reservoir computing has demonstrated high-level performance, however efficient hardware implementations demand an architecture with minimum system complexity. The authors propose a rotating neuron-based architecture for physically implementing all-analog resource efficient reservoir computing system.

A natural pathway in rice and in seven other major crop species degrades 57–89% of accumulated methylmercury and releases Hg into the air. The MeHg demethylation within rice mitigates Hg flux into human food webs, diminishing human cognitive damage and generating global economic benefits of US$30.7–84.2 billion.

The powdery mildew resistance gene Pm13 was introgressed into wheat from Aegilops longissima. Here, the authors report the cloning of Pm13 and reveal that it encodes a MLKL_NTD domain-containing kinase.

Here, the authors establish a design approach for porous materials with a high mass loading polyaniline electrode by using a radial porous nanostructure. The design approach allows for electrodes with high mass loading and rate capability.

MXenes are a family of layered materials which show promise for a variety of (opto-)electronic applications. Here, the authors leverage the variations of the interlayer distance in Ti₃C₂ under external pressure to devise a piezoresistive sensor.

For packaging enzymes into metal–organic frameworks (MOFs), crystalline MOFs are usually used. Here, the authors encapsulated enzymes in amorphous MOFs a via one-pot co-precipitation process under ambient condition, which led to higher enzymatic activity than in a corresponding crystalline MOF composite.

The performance of macroscopic graphene fibers is hampered by lower bonding strength between individual graphene sheets. Authors mitigate this by creating covalent conjugating linkages at sheet edges, improving mechanical and electrical properties.