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A generalized approach is proposed for enhancing contact-electro-catalysis (CEC) in a broader temperature window (up to 180 °C). Its feasibility is verified by CEC-leaching of spent LIB cathodes, with >90% leaching efficiency for all elements in 5 h.

YAP is a key oncogenic driver that has long been considered undruggable. Here, the authors present the development of a nanobody-based bioPROTAC that efficiently degrades endogenous YAP, demonstrating potent anticancer activity and providing a promising therapeutic strategy for YAP-dependent tumors.

Geological evidence from the North Qilian paleo-subduction channel shows that strong blocks deform by dislocation creep, sustain >100 MPa stresses, and their interactions transiently tighten plate coupling, shedding light on deep slow-slip dynamics.

Cloning quantitative trait loci (QTL) in crops is often slow and laborious. Here, the authors describe RapMap, a method to rapidly clone multiple QTL based on F₂ gradient populations coupled with a co-segregation standard, and show how it can be used to identify genes controlling grain size in rice.

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.

Coordinating protein translation with energy supply is a significant challenge faced by cells. Here, the authors found that the protein quality control network may provide a link between the two.

Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modulation of chromatin accessibility to apoptotic genes and accompanied by H3K9me3 dysregulation.

The in vitro characterization of a key event in the early stages of meiosis—the induction of double-strand DNA breaks by the SPO11–TOP6BL complex—provides insight into the catalytic mechanism and evolution of SPO11.

Wu et al. optimized the m⁶A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m⁶A methylation in mouse oocytes and early embryos.

Northern China contains some of the world’s earliest farming societies. Here, authors use 55 ancient genomes to trace the genetic history of human migrations across northern China for the last 7500 years, and document genetic changes mirroring shifts in subsistence strategy.

Plasmid acquisition imposes an adaptive burden, which can be ameliorated by host-plasmid coevolution. Here, the authors characterise virulence plasmids of carbapenem-resistant Klebsiella pneumoniae, and show the discard of certain sequences to enhance survival, conferring an evolutionary advantage.

Improved host-guest electronic interplay within stable metal-organic cages (MOCs) presents opportunities for photocatalysis. Here, the authors use pyridinium-derived ligands with solubilizing counteranions to prepare highly soluble Zr-MOCs and demonstrate the use of host-guest charge-transfer complexation to enhance photo-induced electron transfer.

Strain engineering is a promising method to manipulate properties of two-dimensional (2D) materials but slippage between material and substrate makes strain transfer inefficient. Here the authors overcome slipping effects by encapsulating a 2D material in a polymer substrate.

Here, the authors investigate how cis-regulatory elements (CRE) function in diverse genomic locations. They develop a high-throughput method to assay CRE activity across the genome and apply it to reveal the context dependencies of insulator activity.

Splicing dysfunction has been observed in Alzheimer’s disease but it remains unclear whether splicing defects have a causal role. Here the authors generate a mouse model with perturbed U1 snRNP activity, recapitulating RNA splicing defects, neuron hyperexcitability, neurodegeneration and synergy with the amyloid cascade when crossed with 5xFAD mice.

Comprehensive genomic and transcriptomics analyses of more than 1,300 cases of childhood T-lineage acute lymphoblastic leukaemia identify 15 distinct subtypes that are associated with specific outcomes.

Epitaxial growth of heterostructures composed of materials with large lattice mismatch is challenging. Here, the authors reported the epitaxy of II-VI semiconductor nanorods on plasmonic noble metal, despite a lattice mismatch of more than 40%.

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.

Marginal zone lymphoma (MZL) is a common subtype of B-cell non-Hodgkin lymphoma. Here the authors carry out a two-stage genome-wide association study in over 8,000 Europeans and identify two new MZL risk loci at chromosome 6p, implicating the major histocompatibility complex in the disease for the first time.

RYBP and YAF2 are a pair of paralog subunits of variant PRC1. Here, authors show that RYBP decrease but YAF2 increase during mESC neural differentiation, and that they are not redundant but function differentially in regulating this differentiation.

Fouling is a continuous challenge for the effective application of membranes in oily wastewater treatment. Here, the authors present a hydrophobic chain engineering strategy to regulate the surface of graphene oxide-based membranes at a molecular scale for increased antifouling even at high permeance.

When hydronium ions are enriched in confined water, short hydrogen bonds (SHBs) form due to the constrained space of excess protons between pairs of water molecules. Here authors demonstrate a SHB network confined on the surface of ionic COF membranes with tunable -SO₃H groups, with proton conductivity of 1389 mS cm^-1 at 90 ^oC.

Radiation damage causes DNA foci to form and senescence, causing ulcers. Here, the authors show that a naturally occurring adenosine analogue, cordycepin, prevents cell senescence via an increase in AMPK/NRF2, so blocking ulcers caused by radiation on skin/intestine/tongue damage in rodents.

Shohreh Issazadeh-Navikas and colleagues report on a previously undescribed population of regulatory T (Treg) cells that accumulate in the CNS in response to autoimmune inflammation and are induced by interferon-β (IFN-β). These cells, termed FoxA1+ Treg cells, express the transcription factor FoxA1+, which is required for their development and function. Individuals with multiple sclerosis that respond to IFN-β have an increased frequency of FoxA1+ Treg cells, suggesting that the induction of these cells may account for some of the protective effects of IFN-β.

James Cerhan and colleagues report genome-wide association and meta-analysis studies to identify genetic susceptibility loci for diffuse large B cell lymphoma. They identify four loci that influence genetic susceptibility to this B cell malignancy.

Using 2D-cardiomyocytes and 3D-cardiac organoid models, the authors show that selective serotonin reuptake inhibitors cause mitochondrial dysfunction and sarcomere disorganization, suggesting potential safety concerns associated with their use.