Search

Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

A wearable human–machine interface combines inertial and electromyography sensors with deep learning to robustly extract gesture signals and enable real-time robotic control under diverse motion artefacts in dynamic environments.

In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators underlying 31 immune and aging traits, including Parkinson’s disease.

Intestinal motility disorders that can occur following small intestine resection often require regular monitoring. This study reports a biodegradable ultrasound contrast tape (BioUCT) that adheres to the intestine for high-contrast imaging for up to two weeks for non-invasive monitoring of postoperative intestinal motility.

Glucocorticoid resistance is partly due to epigenetic alterations, but the regulatory mechanisms driving these remain poorly understood. Here, a link between the activity of a lineage-specific transcription factor PU.1 and epigenetic modulators mediating the response to glucocorticoids is described in acute lymphoblastic leukemia.

Using ¹⁹F nuclear magnetic resonance to study LiF–LiH solid solutions revealed that it is present in the solid–electrolyte interphase of lithium metal batteries and confirms the heterogeneous nature of LiF in such interphases.

Long, chemically modified pegRNAs are rapidly synthesized using an optimized splint ligation approach.

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

A short-lived carbon release preceded the PETM. Here the global nature of this is confirmed, effects on the surface ocean carbon cycle are resolved, and a thermogenic CO₂ source is inferred.

SHP2 regulates pro-angiogenic VEGF-VEGFR signalling, but its role in tumour angiogenesis is unclear. Here the authors show that endothelial cell-specific deletion of SHP2 impairs tumour growth and angiogenesis in syngeneic mouse models through ASK1-c-JunSOX7 signalling axis.

A one-step fluorescence assay relying on suboptimal protospacer adjacent motifs for Cas12a detects SARS-CoV-2 RNA in nasopharyngeal samples in less than 20 minutes with a sensitivity comparable to that of RT–qPCR.

Understanding of artificial neural networks function, and their ability to effectively solve specific tasks, still require more rigorous analytical background. Using network science and dynamical systems tools, the authors develop a framework for predicting the performance of artificial neural networks

Multiomics joint analyses based on a structural variant (SV) map from 16 genome assemblies and 2,105 resequenced accession genomes shed light on the regulatory effect of SVs on gene expression and trait variation in Brassica napus.

Huang et al. show that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.

Using a Cas13d-based nanosystem to knockdown lung protease cathepsin L, Cui et al. demonstrated that CRISPR–Cas system can be used to prevent and treat SARS-CoV-2 infection by targeting mRNA of host genes.

In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tumours and cell lines and identify a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) genes, with potential therapeutic applications.

Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.

A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.

Validation of the safety and performance of a wearable ultrasound sensor for the monitoring of blood pressure in clinical settings showed that the sensor met established safety and accuracy requirements.

SspABCD–SspE is a widespread bacterial defence system against phage infection, in which SspABCD is responsible for introducing phosphorothioate modifications and SspE serves as a nickase that cleaves foreign DNA.

Topological insulators (TIs), as a powerful reservoir of spin-orbit coupling, became popular to replace the heavy metals in bilayers to achieve magnetization switching with high efficiencies and low threshold current densities. By magnetically doping a single layer TI, the authors observe a zero-field magnetization of the TI that can be switched by dc current.

A method to label membrane proteins with a DNA tag has been developed that enables the selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells. As a demonstration, a 30-million-compound DNA-encoded chemical library is screened against folate receptor, carbonic anhydrase 12 and epidermal growth factor receptor on live cells.

Domain wall formation and propagation using a small electric voltage are demonstrated in ferro-rotational 1T-TaS₂, although the ferroic order does not couple with electromagnetic fields, providing an opportunity for the manipulation and application of ferro-rotational order.

A wearable ultrasound patch monitors subjects in motion using machine learning and wireless electronics.

The Arctic is under-represented in surface temperature datasets and this could affect estimates of global warming. A new dataset with greater coverage of the Arctic shows a higher warming rate of 0.112 °C per decade compared to 0.005 °C from IPCC AR5.

Dealing with the explosive growth of diverse image data in the era of big data poses challenges for storage. Feng et al. propose a memristor-based near-storage in-memory processing system to boost the energy and storage efficiency.

Ultrasound may be used to non-invasively modulate the brain. Here the authors describe acoustic nanobubble-mediated ultrasound stimulation of specific brain region in male mice.

A conformal ultrasound patch can be used for hands-free volumetric imaging and continuous monitoring of cerebral blood flow

The development of organic afterglow materials with sufficient color purity and high quantum efficiency for hyperafterglow is a great challenging. Here, the authors demonstrate an efficient strategy to achieve hyperafterglow emission through sensitizing and stabilizing isolated fluorescence chromophores by integrating multiresonance fluorescence chromophores into afterglow host in a singlecomponent copolymer.

Chandrakanthan et al. identify Mesp1-derived PDGFRA⁺ stromal cells as aortic endothelial precursors that regulate long-term haematopoietic-stem-cell generation during development, thus providing a new potential tool to generate engraftable haematopoietic stem cells.

Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.

Low dimensional lead halide perovskites possess intriguing optical properties that are still under debate. Here Cui et al. use hydrogen bonds containing spacers to synthesize highly luminescent perovskites with fully isolated lead-bromide octahedras and shed light on the origin of the emission.

Topology optimization, relevant for materials design and engineering, requires solving of challenging high-dimensional problems. The authors introduce a self-directed online learning approach, as embedding of deep learning in optimization methods, that accelerates the training and optimization processes.

While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in the formation and maintenance of the human blood hierarchy.

In leukemic mice, fasting reduces the development of acute lymphoblastic leukemia, but not acute myeloid leukemia, via upregulation of leptin receptor expression and signaling in the leukemic cells.

Large-size single-crystal van der Waals layered Bi₂SeO₅ has been synthesized with a high dielectric constant and high breakdown field strength for two-dimensional electronics applications.

The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and support the infiltration of tumour cells into tissues.

mRNA vaccines produce rapid and precise immune responses against infectious diseases and cancers. Chen et al. discuss the development of biomaterials and nanotechnology for mRNA vaccines, how these are designed and evaluated and the underlying mechanisms of cellular uptake and immune stimulation.