Nature Search

Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

P: 1-13
Identification of SARS-CoV-2 M^pro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.

Nobuyo Higashi-Kuwata
Kohei Tsuji
Hiroaki Mitsuya
ResearchOpen Access25 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial

A first-in-human clinical trial of iPS cell-derived invariant natural killer T cells in patients with recurrent head and neck cancer demonstrated safety and early signs of efficacy, showing tumor growth suppression and activation of immune pathways.

Tomohisa Iinuma
Tomoya Kurokawa
Shinichiro Motohashi
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Polo-like kinase 4 and Stromal antigen 3 are not associated with recurrent pregnancy loss caused by embryonic aneuploidy

Hiroyuki Yoshihara
Mayumi Sugiura-Ogasawara
Katsushi Tokunaga
ResearchOpen Access29 May 2020
Human Genome Variation

Volume: 7, P: 1-6
Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA

Yosuke Matsumura
Yosuke Hayashi
Yoshimitsu Izawa
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’

Tomoya Isobe
Masatoshi Takagi
Junko Takita
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Cytoneme-mediated transport of active Wnt5b–Ror2 complexes in zebrafish

In zebrafish embryos, active complexes of Wnt5b and its membrane-bound receptor Ror2 are transported between cells via cellular protrusions called cytonemes to initiate paracrine Wnt5b signalling in cells that do not endogenously express the receptor.

Chengting Zhang
Lucy Brunt
Steffen Scholpp
ResearchOpen Access20 Dec 2023
Nature

Volume: 625, P: 126-133
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans

In humans, conception during cold seasons is shown to exhibit higher brown adipose tissue activity and adaptive thermogenesis, and lower body mass index and visceral fat accumulation in the offspring.

Takeshi Yoneshiro
Mami Matsushita
Masayuki Saito
ResearchOpen Access07 Apr 2025
Nature Metabolism

Volume: 7, P: 778-791
Self-assembled dodecyl group-modified gelatin microparticle-based hydrogels with angiogenic properties

To achieve growth factor-free angiogenesis, a lipopolysaccharide-mimicking dodecyl group-modified gelatin microparticle (C12-MP) was fabricated. The water suspension of C12-MP formed a syringe-injectable hydrogel with shear-thinning properties. The C12-MP hydrogel induced localized and sustained angiogenesis in vivo for 22 days by stimulation of toll-like receptor 4 accompanied by endogenous growth factor secretion.

Yosuke Mizuno
Tetsushi Taguchi
ResearchOpen Access06 Jul 2020
NPG Asia Materials

Volume: 12, P: 1-12
Proton pump inhibitors and potassium competitive acid blockers decrease pembrolizumab efficacy in patients with metastatic urothelial carcinoma

Keitaro Iida
Taku Naiki
Takahiro Yasui
ResearchOpen Access30 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs

Junichi Taira
Kahori Murakami
Shunsuke Aoki
Research08 Aug 2022
The Journal of Antibiotics

Volume: 75, P: 552-558
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al. show that chalcone isomerase-like proteins bind to and reduce the catalytic promiscuity of chalcone synthase, ensuring efficient flavonoid production in planta.

Toshiyuki Waki
Ryo Mameda
Toru Nakayama
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-14
Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control

Motoshi Iwao
Ryota Tanaka
Hiroki Itoh
ResearchOpen Access09 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Superconductivity in In-doped AgSnBiTe₃ with possible band inversion

Tsubasa Mitobe
Kazuhisa Hoshi
Yoshikazu Mizuguchi
ResearchOpen Access24 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Hidden pressurized fluids prior to the 2014 phreatic eruption at Mt Ontake

Phreatic volcanic eruptions can be unexpected and devastating. Here the authors, using seismic-based methodologies, find that pressurized fluids accumulated 5 months before the deadly phreatic eruption at Mt Ontake; a period previously considered as completely quiescent.

Corentin Caudron
Yosuke Aoki
Toshiko Terakawa
ResearchOpen Access17 Oct 2022
Nature Communications

Volume: 13, P: 1-9
Bulk superconductivity in a four-layer-type Bi-based compound La₂O₂Bi₃Ag_0.6Sn_0.4S_5.7Se_0.3

Rajveer Jha
Yosuke Goto
Yoshikazu Mizuguchi
ResearchOpen Access19 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
Early prophylaxis of central venous catheter-related thrombosis using 1% chlorhexidine gluconate and chlorhexidine-gel-impregnated dressings: a retrospective cohort study

Tomoko Yamashita
Ayako Takamori
Yoshiro Sakaguchi
ResearchOpen Access29 Sept 2020
Scientific Reports

Volume: 10, P: 1-7
Role of corticotropin-releasing factor on bladder function in rats with psychological stress

Masaya Seki
Xin-Min Zha
Osamu Yokoyama
ResearchOpen Access08 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Na_1−xSn₂P₂ as a new member of van der Waals-type layered tin pnictide superconductors

Yosuke Goto
Akira Miura
Yoshikazu Mizuguchi
ResearchOpen Access27 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model

Asuka Nishino
Yosuke Tajima
Hiroshi Ito
ResearchOpen Access27 Apr 2016
Scientific Reports

Volume: 6, P: 1-8
Multimorbidity patterns in relation to polypharmacy and dosage frequency: a nationwide, cross-sectional study in a Japanese population

Takuya Aoki
Yosuke Yamamoto
Shunichi Fukuhara
ResearchOpen Access28 Feb 2018
Scientific Reports

Volume: 8, P: 1-8
Evidence of reactivation of a hydrothermal system from seismic anisotropy changes

In this study, the authors monitor a hydrothermal fluid surge through seismic anisotropy changes at the Hakone volcanic field, Japan. The authors find the anisotropy changes to be set off by the seismic waves of the 2011 Tohoku-Oki earthquake, that reactivated the hydrothermal system.

Maria Saade
Kohtaro Araragi
Florent Brenguier
ResearchOpen Access21 Nov 2019
Nature Communications

Volume: 10, P: 1-8
Calcium-dependent Ret activation by GDNF and neurturin

Chika Nozaki
Naoya Asai
Masahide Takahashi
Research26 Jan 1998
Oncogene

Volume: 16, P: 293-299
CD8⁺ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

The cellular and molecular mechanisms underlying the resolution of non-alcoholic steatohepatitis remain incompletely understood. Here the authors report a single cell-based analysis that identified CD8 + tissue-resident memory T cells, which contribute to resolution of liver fibrosis potentially via elimination of hepatic stellate cells through Fas-mediated cytotoxicity.

Yuzo Koda
Toshiaki Teratani
Nobuhiro Nakamoto
ResearchOpen Access22 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Propagation mechanism of polymer optical fiber fuse

Yosuke Mizuno
Neisei Hayashi
Shin-ichi Todoroki
ResearchOpen Access25 Apr 2014
Scientific Reports

Volume: 4, P: 1-4
Slip complementarity and deficit of the East Anatolian Fault revealed by geodetic observations

Geodetic observations suggest segments of the East Anatolian Fault which display interseismic slip deficits correlate with the rupture zones of the 2020 Elaziğ earthquake and the 2023 Kahramanmaraş earthquake doublet and may be useful to identify high risk regions.

Bingquan Han
Chen Yu
Jianbing Peng
ResearchOpen Access27 Nov 2025
Communications Earth & Environment

Volume: 6, P: 1-16
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation

Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation.

Masaki Tsuchiya
Yuji Hara
Masato Umeda
ResearchOpen Access24 May 2018
Nature Communications

Volume: 9, P: 1-15
Structural basis for specific inhibition of Autotaxin by a DNA aptamer

SELEX selections and crystallographic analyses have allowed development of a DNA aptamer that inhibits autotaxin with high potency and specificity, and exhibits efficacy against bleomycin-induced pulmonary fibrosis in model mice.

Kazuki Kato
Hisako Ikeda
Osamu Nureki
Research04 Apr 2016
Nature Structural & Molecular Biology

Volume: 23, P: 395-401
The liver–brain–gut neural arc maintains the T_reg cell niche in the gut

A liver–brain–gut neural circuit responds to the gut microenvironment and regulates the activity of peripheral regulatory T cells in the colon by controlling intestinal antigen-presenting cells in a muscarinic signalling-dependent manner.

Toshiaki Teratani
Yohei Mikami
Takanori Kanai
Research11 Jun 2020
Nature

Volume: 585, P: 591-596
A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study

Naoyuki Tominaga
Eiji Sadashima
Naoyoshi Nagata
ResearchOpen Access04 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
DNA damage triggers reprogramming of differentiated cells into stem cells in Physcomitrella

This study reports that DNA strand breaks trigger the reprogramming of differentiated leaf cells into stem cells without cell death in Physcomitrella, which requires the DNA damage sensor ATR kinase and the STEM-CELL INDUCING FACTORs (STEMINs).

Nan Gu
Yosuke Tamada
Mitsuyasu Hasebe
Research17 Aug 2020
Nature Plants

Volume: 6, P: 1098-1105
Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Sho Suzuki
Naoyuki Tominaga
Naoyoshi Nagata
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Physcomitrella STEMIN transcription factor induces stem cell formation with epigenetic reprogramming

In moss, a subgroup of uncharacterized AP2/ERF transcription factors called STEMIN promotes stem cell formation and regeneration, specifically through a repressive chromatin mark on its target genes.

Masaki Ishikawa
Mio Morishita
Mitsuyasu Hasebe
Research08 Jul 2019
Nature Plants

Volume: 5, P: 681-690
Online education and the mental health of faculty during the COVID-19 pandemic in Japan

Yosuke Kita
Shoko Yasuda
Claudia Gherghel
ResearchOpen Access30 May 2022
Scientific Reports

Volume: 12, P: 1-9
Mechanism differences in the start time of sublingual immunotherapy in a mouse allergic airway inflammation model

Akira Saito
Toshiyuki Koya
Toshiaki Kikuchi
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage

Yosuke Matsumoto
Keiko Shinjo
Yutaka Kondo
ResearchOpen Access27 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

Toshihide Iwashita
Masashi Kato
Masahide Takahashi
Research14 Jul 1999
Oncogene

Volume: 18, P: 3919-3922
Infrared laser–induced gene expression in single cells characterized by quantitative imaging in Physcomitrium patens

A study optimizes a system effectively inducing gene expression by infrared laser heating and characterizes the induction profile of single cells in the different conditions through quantitative imaging analysis in the moss Physcomitrium patens.

Takumi Tomoi
Yuka Yoshida
Yasuhiro Kamei
ResearchOpen Access06 Nov 2024
Communications Biology

Volume: 7, P: 1-12
Imaging evolution of Cascadia slow-slip event using high-rate GPS

Yuji Itoh
Yosuke Aoki
Junichi Fukuda
ResearchOpen Access03 May 2022
Scientific Reports

Volume: 12, P: 1-12
Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts

Akitoshi Nakashima
Shi-Bin Cheng
Shigeru Saito
ResearchOpen Access07 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts

Akitoshi Nakashima
Kazuma Higashisaka
Shigeru Saito
ResearchOpen Access02 Apr 2019
Scientific Reports

Volume: 9, P: 1-13
Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

Daisuke Yamazaki
Ayaka Hasegawa
Hiroaki Miki
Research22 Jan 2019
Oncogene

Volume: 38, P: 3962-3969
Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130^Cas mediated by Ret kinase

Hideki Murakami
Toshihide Iwashita
Masahide Takahashi
Research18 Mar 1999
Oncogene

Volume: 18, P: 1975-1982
Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

Naoki Ishii
Naoyoshi Nagata
Mitsuru Kaise
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics

Otoya Ueda
Naoko A. Wada
Kou-ichi Jishage
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-15

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