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Li, Huo, Zhang, Liu and colleagues report that the transcripts of genes involved in haematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N⁴-acetylcytidine catalytic activity.

Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolution.

In this work, the luminescence performance of oxide phosphors was significantly improved and tuned through a vitrification followed by crystallization protocol. This enabled the fabrication of a high-power solid-state lighting device.

This study achieves ultrafast all-electrical perpendicular magnetization switching with a pulse width of 16 ps and an energy consumption of 41 fJ/bit in a CoTb/Ti/CoFeB/MgO heterostructure, enabled by combining the in-plane and out-of-plane spin current.

Neuraminidase activity of NEU1 regulates insulin resistance and glucose tolerance. Here the authors report that NEU1 also inhibits hepatic gluconeogenesis in a non-enzymatic manner by binding SAM68, thereby activating GCN5 transcription.

Li et al. report a molecularly tailored strategy to fabricate durable, transparent anti-triboelectric coating by chemically crosslinking electron-donating and electron-withdrawing components.

The role of gut microbiota–metabolism crosstalk in polycystic ovary syndrome (PCOS) remains unclear. Here, the authors revealed that sialic acid exacerbates PCOS pathogenesis by remodeling gut microbial bile acid metabolism and FXR activation.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

This study demonstrates involvement of Lactobacillus/vitamin A&E–Sting1/Slc9c2 axis in mediating chronic stress-induced oligoasthenozoospermia via germ cell apoptosis and sperm mobility impairment and microbiota restoration is a therapeutic strategy

Extreme environments host diverse microbes, yet their global diversity remains underexplored. Here, the authors analyze both isolate genomes and metagenomes from various extreme habitats to construct a microbial genomic catalog, and use protein language models to identify antimicrobial peptides active against drug-resistant pathogens.

Priority identification of ethane is challenging. Here the authors report flexible–robust TYUT-18 with binary pores, showing distinct gate-opening pressures for ethane and ethylene, reducing competitive adsorption and improving separation efficiency.

By linking axial coordination chemistry to spin-state control and reactive oxygen species selectivity, this study delivers mechanistic insights and a versatile design principle for single-atom catalysts in environmental catalysis.

Microplastic-oil co-contaminants are environmentally concerning, though conventional membranes are typically designed for single pollutant removals. Here the authors design a membrane using a sodium periodate-assisted co-deposition of caffeic acid and ε-polylysine method for the removal of complex mixtures from water.

Fe3GaTe2 is a room temperature van der Waals ferromagnet, which, despite having a centrosymmetric crystal structure, has both a large Dzyaloshinskii-Moriya interaction and hosts topological spin textures. Here, Xia, Luo, Malik and coauthors unravel this mystery, showing the critical role of field cooling in the breaking of inversion symmetry in Fe3GaTe2.

Leukemic stem cells (LSCs) drive relapse and therapy resistance in acute myeloid leukemia (AML). Here, the authors show that increasing the stiffness of LSCs reduces their stemness and enhances their susceptibility to natural killer cell-mediated immunotherapy in AML.

sm-PORE-cupine combines SHAPE-based chemical probing with nanopore-based direct RNA sequencing to identify RNA structural ensembles in the SARS-CoV-2 genome and the Candida albicans transcriptome.

Poisonous plants encroachment in grasslands shows stage-dependent ecological thresholds, with early losses in root productivity and biodiversity but partial recovery of multifunctionality beyond 50% coverage, based on analyses of 20 ecosystem variables across 465 standardized field plots.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

Bronchiectasis and asthma can co-exist in the same patient, and the characteristics may be different from bronchiectasis alone. Here the authors characterise the function of ILC3 cells and how IL-17C potentiates IL-17A expression promoting a neutrophil dominated asthma endotype in mouse bronchiectasis-asthma models.

Oversimplified synthetic wastewater misjudges fouling drivers and distorts economics. This study reveals that organic synergies counterintuitively mitigate membrane fouling, advocating for compositional fidelity to bridge lab-industry gaps.

Scalable fabrication of ordered perovskite quantum dot superlattices enables high-efficiency, ultrahigh-resolution LEDs and active-matrix displays with greatly improved brightness, stability and device lifetime.

Gene correction in the lung is achieved with inhalable mRNA lipid nanoparticles containing an amino acid-derived ionizable lipid identified from screening and structure–function optimization studies.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Porous materials offer new opportunities to break azeotropes, enabling energy-efficient separations that are otherwise challenging with conventional distillation methods. Now an ionic metal‒organic framework featuring potassium-ion cluster gates has enabled the separation of methanol and dimethyl carbonate, delivering the latter in battery-grade purity.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.

An optimized thermal evaporation process for tin-based perovskites enables precise strain engineering in the perovskite layer, resulting in perovskite light-emitting diodes with a half-lifetime of 1,250 h at a constant current density of 100 mA cm⁻² and a peak external quantum efficiency of 6.6% for emission at 944 nm.

SirM methyltransferase upregulates Salmonella HemL-dependent haem production to enable haem-dependent inhibition of phagocytosis and promote infection in mice.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Liquid metals can create flexible, conductive composites, but often show a trade-off between these properties. Here, the authors optimise the interactions between liquid-metal and polyurethane to obtain a composite with high thermal conductivity and stretchability at low liquid metal loading.

Maintaining lower temperature is critical for the quality of grain storage. Here, authors explore the applicability of radiative cooling material applied to granary in ten climates, and demonstrate its broad potential for promoting sustainable storage, especially in resource-constrained regions.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Group 2 innate lymphoid cells (ILC2) are known to contribute to the pathology of allergic asthma but the molecular mechanism by which they are getting activated are not fully known. Here authors show that the mTORC1 pathway, partly via neuromedin U receptor 1 (NMUR1), plays a pivotal role in ILC2 cell activation, and that inhibition of this signalling alleviates allergic asthma in mice.

The authors resolve 63 structurally diverse haplotype structures for the 22q11.2 deletion syndrome region. Deletion risk differs depending on structure; individuals of African ancestry are enriched for inverted repeats that predispose to inversion.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Nanozymes are promising for controlling plant bacterial diseases, but conventional nanozymes suffer from low bacterial affinity, inefficient enzyme-like activity, and thus poor antibacterial efficacy. Here, the authors report a copper single-atom nanozyme that outperforms commercial thiodiazole copper in controlling plant bacterial diseases via intelligent capture and photo-enhanced activity.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.