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Intraspecific trait variation influences how plants grow and interact in communities, yet it is still poorly understood for roots. This study explores latitudinal patterns of root intraspecific trait variation among species within natural plant communities, along with its drivers and implications.

FHIRM-TPM 3.0 is a miniature microscope for multicolor two-photon imaging in freely moving mice. In addition to the multicolor imaging abilities achieved with the help of a specially designed optical fiber, the microscope is also compatible with multiple lenses for a choice of field of view and resolution.

The NINJ1 protein regulates plasma membrane rupture by altering membrane biomechanical properties, independent of cell death programs.

The antiferromagnetic moments in the topological insulator/antiferromagnetic insulator bilayer (Bi,Sb)₂Te₃/α-Fe₂O₃ can be reversibly switched using electrical currents at room temperature, and with a critical current density that is one order of magnitude smaller than that required in heavy-metal/magnetic insulator systems.

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Electromagnetic oscillations are a key technological bottleneck that restricts the safe operation of power electronics-dominated power systems. Here, authors propose a generalized linear time-periodic participation factor and sensitivity theory within the eigenstructure-preserved framework for stability quantitative analysis.

Here, the authors find that high-pressure treatment in a diamond anvil cell turns initially non-emissive organic small molecules emissive after decompression, where their color can be tuned through the maximum applied pressure.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Phase 1 trial results of the messenger RNA vaccine candidate BNT162b1, which encodes the receptor-binding domain of the SARS-CoV-2 spike protein, show safety and elicitation of antibody and T cell responses in both younger and older Chinese adults.

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

Rare genetic variants in UNC93B1 predispose to childhood-onset lupus via TLR7/-8–IRAK1/-4, validated with a corresponding mouse model.

The efficacy of anticancer gene therapy varies by the delivery efficiency of the mRNA cargo as well as their injection method. Here this group reports using LNP-delivered mRNA encoding 3 C protease treated on three different types of solid tumor models showing effective tumor growth inhibition, with three different injection methods, respectively.

An interfacial catalytic polymerization strategy is able to turn nature-derived compounds into high-quality membranes for reverse osmosis, challenging traditional approaches for membrane production that use toxic amine-based monomers.

Understanding the emission patterns of chlorinated and brominated polycyclic aromatic hydrocarbons (Cl/BrPAHs), a group of persistent organic pollutants, is critical to control them. This study presents a global inventory and source attribution analysis of Cl/BrPAH emissions.

Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction.

An intermediate affinity state of integrins on platelets has been identified to be induced by a biomechanical activation pathway and is shown to promote platelet aggregation.

Multiscale analysis including ChIP-Seq and Hi-C reveals Sul14a, one of the Lrs14 family protein, orchestrates chromatin organization as an essential and cyclically transcribed nucleoid-associated protein (NAP) in archaea of the order Sulfolobales.

In a randomized phase 3 trial, neoadjuvant anti-PD-1 plus either paclitaxel and cisplatin or nab-paclitaxel and cisplatin elicited a significantly superior pathological complete response rate versus neoadjuvant paclitaxel and cisplatin alone in patients with resectable locally advanced esophageal squamous cell carcinoma.

Nanocomposite fibres that display rapid and reversible changes of colour when an electric current is passed through them could have applications in sensing.

Intermediate soil acidification alters the denitrifier community composition and induces high nitrous oxide (N₂O) emissions, which contributes to the observed acceleration of N₂O emissions from global soils

The assembly of nanoparticles into macroscopic materials forms the basis for various advanced material applications. Here, the authors develop macroscopic materials that are both recastable and mechanically robust, despite being composed purely of carbon dots.

Here, Lu and co-workers show the synthesis of high-quality, nitrogen-doped, mesoporous graphene particles using CVD with MgO as the catalyst and template. When used as the anode for a lithium ion battery, their unique architecture allows for excellent rate performance and cycling stability.

The ability to regulate membrane pore size as needed has been a topic of active research for developing next-generation stimuli-responsive smart membranes. Herein, the authors report the observation of operando regulation of the pore size of A membrane based on electro-osmotic swelling.

PRS-CSx is a polygenic risk score construction method that improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations.

Most attempts to co-cultivate the artificial microbial communities fail mostly due to the mismatched rates of consumption and production of nutrients among subpopulations. Here, the authors develop a microbial swarmbot mediated spatial segregation method to assemble stably coexisting consortia with both flexibility and precision.

Two or more enzymes encapsulated in a thin polymer shell can lower blood alcohol levels in intoxicated mice, offering a way to prevent liver injury arising from the overconsumption of alcohol.

Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

In this study, the authors isolate and characterize BBIBPCorV inactivated vaccine-elicited human antibodies. They show that these can broadly neutralize a range of SARS-CoV-2 variants and protect mice from Delta and Omicron infection. The neutralization mechanism of bispecific antibodies were solved structurally.

Multiple alternating layers of two-dimensional materials and epilayers are grown on III–N and III–V substrates in a single growth run. Then, each epilayer is harvested by mechanical exfoliation, producing multiple freestanding membranes from a single wafer.

The removal of acetylene from ethylene/acetylene mixtures is an industrially important but challenging task. Here the authors report a microporous metal–organic framework with optimized pore/cage space design and chemical functionalization, capable of removing acetylene from low concentration mixtures.

Molecular details of the synergy between integrins and syndecans are poorly understood. Here, Fiore et al. show that syndecan-4 and α₅β₁integrin form a trimolecular complex with Thy-1 that exhibits ‘dynamic catch’ behaviour, in which force strengthens the synergistic binding and modulates signalling at the focal adhesion level.

Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin α_IIbβ₃ on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotics aspirin or clopidogrel.

Proton exchange membrane fuel cells often suffer from low lifetimes and high cost. Here, the authors enhance the transient power performance and durability of these fuel cells by integrating a thin layer of tungsten oxide within the anode, which acts as a hydrogen reservoir, oxygen scavenger, and a regulator for the hydrogen-disassociation reaction.

Massive stores of carbon and nutrients in permafrost could be released by global warming. Here the authors show that though warming across the Tibetan alpine permafrost region accelerates nitrogen liberation, contrary to expectations the elevated nutrients do not alleviate plant nitrogen limitation.

Integrins and talin are parts of a ‘molecular clutch’ that mechanically links the actin cytoskeleton to the extracellular matrix. Elosegui-Artola et al. now reveal a tunable rigidity threshold, above which talin unfolds to mediate force transduction.

Confinement-induced organization of nanoparticles is utilized to generate new structures with novel optical or magnetic properties. Here, Li et al.show that colloidal liquid crystals formed by rod-like nanoparticles self-assemble into various geometries depending on the degree of spherical confinement in droplets.