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Authors develop a general paradigm combining fluorescence resonance energy transfer imaging, gel electrophoresis and mass spectrometric analysis to identify and quantify intracellular N-acetylglucosamine modified glycoRNAs.

Bacterial therapies for cancer face safety and complexity challenges. Here, the authors develop an engineered Serratia marcescens platform that leverages natural pigment biosynthesis to trigger antitumor immunity and enable rapid bacterial clearance, controlled by near-infrared light.

Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories by temporarily silencing and remodeling the engram neurons.

Kidney stone disease is increasing worldwide. Cao et al. perform a cross-ancestry GWAS meta-analysis of the condition, identifying risk loci and potential causal variants, and construct a cross-population polygenic risk score.

Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.

Fan and colleagues show that the neurotransmitter GABA signals in intestinal ILC3s to suppress IL-17A production through a regulatory loop that involves suppression of C/EBP-β and induction of Igfb7.

Harvesting bio-mechanical energy is a promising route to powering wearable electronics, however design obstacles remain. Here the authors report on a triboelectric nanogenerator with optimized materials and design that can sustainably power an electronic watch and fitness tracker solely by human motion.

Decadal-scale observations reveal that plant diversity stabilizes ecosystem productivity over time. Phylogenetic diversity is the key driver of long-term stability, whereas plant height shapes short-term productivity dynamics.

Calmodulin (CaM) activates target proteins to regulate a variety of cellular processes. Here, the authors report that CaM–target binding is disturbed by a fungal effector PdCDIE1, leading to ROS-dependent plant cell death.

Zhang et al. present a differentiable-physics simulation approach that enables autonomous aerial robot swarms to navigate complex environments. High-speed navigation and robust performance in both multi-agent and single-agent scenarios are demonstrated with low-cost hardware platforms.

Pulmonary fibrosis is a severe lung disease with limited clinical therapies. Here the authors show that chimeric antigen receptor cells can rescue pulmonary fibrosis in a mouse model, and they further investigate the mechanism of lung regeneration after treatment.

Crumpled graphene structures are promising for electrochemical energy storage. Here, the authors synthesize deeply crumpled pinecone-like graphene sheets, which show self-adaptive folding-unfolding behaviours in cycling leading to robust battery performances.

Self-charging systems based on the connection of a nanogenerator and an energy storage unit through a rectifier can have low energy storage efficiencies. Here, the authors design the charging cycle to maximize the energy storage efficiency of a triboelectric nanogenerator by introducing a motion-induced switch.

Triboelectric nanogenerators are a technology for converting mechanical energy into electricity, but standards for quantifying their performance is lacking. Here, the authors present figure-of-merits to quantitatively evaluate the performance of triboelectric nanogenerators and establish a foundation for further development.

Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and identify the transcription factors TCF3 and TCF12 as key regulators of folliculogenesis.

The high output voltage of triboelectric nanogenerators enables well-controlled ion pulses for nanoelectrospray molecular mass spectrometry and surface modification.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

Platinum-based chemotherapeutics can be locally released in tumours by leveraging the radiation-induced reduction of platinum prodrugs.

To fully exploit the potential of multiferroic materials the control of their intrinsic degrees of freedom is a prerequisite. Here, the control of spin orientation in strained BiFeO₃ films is demonstrated elucidating the microscopic mechanism of the complex interplay of polar and magnetic order.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Gas discharge plasma sources are bulky and of limited use in remote areas with no external power supply. Here the authors create triboelectric plasma by triggering TENGs with mechanical stimuli and discuss its application as a portable plasma source.

Magmatic and tectonic activity at mid-oceanic ridges can give detailed insights into high-temperature hydrothermal circulation of fluids. The authors here present geochemical and geophysical datasets that suggest a hydrothermal system penetrating the upper lithospheric mantle at an ultra-slow spreading mid-oceanic ridge.

Nanowires and nanotubes are ideal candidates for energy applications but inorganic multielement oxides are less well studied. Here, the authors propose a gradient-electrospinning followed by controlled-pyrolysis method to synthesize various controllable one dimensional metal oxide nanostructures.

Difficulties in separating tribo and piezoelectric hybrid signals can lead to an overestimated contribution of the latter. Here, authors propose a method to separate these hybrid signals in the time domain, precisely extracting piezoelectric charge transfer for performance evaluation.

Binding of RNA polymerase II during zygotic genome activation in mouse embryos is determined using the newly developed method Stacc–seq.

Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R. Wayne Chen and his colleagues now detail the molecular mechanism by which intra–sarcoplasmic reticulum calcium ions interact with the gate of the calcium release channel RyR2, explaining how calcium waves are initiated and thereby contribute to calcium-triggered arrhythmias.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Rescue of motor and behavioral deficits in a primate model of Parkinson’s disease following autologous transplantation of iPSC-derived dopaminergic neural progenitors without immunosuppression.

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.