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This study highlights a strategy to additively manufacture lightweight, strong, and ductile heat-resistant aluminum alloys. The partial solid-state amorphization of the nanoprecipitates during high-temperature tension offers an additional toughening mechanism.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Transition metal oxides are interesting for advancing technology as they can combine ease of synthesis, resilience to defects, and high environmental stability, yet few exhibit semiconducting properties, limiting their engineering potential. Here, the authors transform insulating oxides into semiconductors with ultra-low thermal conductivity by introducing configurational entropy, offering a generalizable approach to designing advanced thermoelectric materials with tailored electronic and thermal properties.

All-van der Waals multiferroic tunnel junctions exhibit four non-volatile resistance states with full layer tailorability, enabling up to 10⁶% tunnelling electroresistance, 10⁴ A cm⁻² ON-state current density and room temperature operation.

Altermagnets are characterized by fully compensated magnetic moments yet break time-reversal symmetry, leading to symmetry-enforced momentum dependent spin splitting. While demonstrations of almagnetism have typically proceeded via spectroscopic probes like ARPES, here Mali, Zhao and coauthors show that nonlinear transport can serve as a sensitive probe to screen for altermagnetic candidates, using Ca₃Ru₂O₇ as a case study.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

He, Wang, Shen, Dong and colleagues find that unsaturated fatty acids enriched in a black rice diet inhibit amyloid pathology, rescue cognition and restore physiological lifespan in mouse models of Alzheimer’s disease via allosteric activation of GPR120.

In this Review, the authors synthesize current knowledge of extrachromosomal DNA in urothelial carcinoma. By consolidating rapidly evolving evidence, this Review provides a comprehensive framework for understanding extrachromosomal DNA biology in urothelial carcinoma and its implications for precision oncology.

One particularly useful feature of van der Waals materials is the ability to combine layers of different materials into a single heterostructure, which can have superior properties than any of the constituent materials alone. Here, Cheng et al. combine two interlayer-antiferromagnetic chromium trihalides, CrI₃ and CrCl₃ in close proximity, and demonstrate ferromagnetic coupling between them.

Layering quantum materials can produce interesting phenomena by combining the different behaviour of electronic states in each layer. A layer-sensitive measurement technique provides insights into the physics of a magnetic topological insulator.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

Strong magnetic interfacial coupling in van der Waals heterostructures provides a new platform for discovering novel physics and effects. Here, the authors report the formation of skyrmion lattice in the WTe₂/Fe₃GeTe₂ van der Waals heterostructure and a Dzyaloshinskii–Moriya interaction with a large energy density of 1.0 mJm⁻².

The interaction between perovskite oxides and water can have a significant influence on practical performance. Here the authors study the dynamics of surface water adsorption and hydroxide formation during monolayer formation on a ruthenate.

Strategies to balance the emission wavelength and molecular weight of NIR-II dyes, particularly low molecular-weight (<500 Da) dyes, are missing. Here, the authors devise an approach that tunes NIR-II emissions by reducing Coulomb attraction interaction and use it to extend the emission wavelength of GFP chromophore-based dyes LS1-12 from the visible range into the NIR-II region.

In situ vibrational electron energy-loss spectroscopy is used to examine phonon transport dynamics across the AlN–SiC interface during thermal transport at sub-nanometre resolution, demonstrating a sharp temperature drop within about 2 nm across the interface.

The efficacy of antiangiogenic therapy in the clinic is often limited by the emergence of resistance. Here, the authors show that in ovarian cancer anti-VEGF inhibitors induce the overexpression of CD5L in endothelial cells through hypoxia-driven PPARy activation and that blocking CD5L can overcome resistance.

Translation and rotation are the two most fundamental forms of diffusion. Here, the authors provide evidence of the coupling between rotation and translation under confinement, and find that asymmetric rotations disrupt the order of molecular diffusion in zeolites, which can be applied to studies of selective separation.

Using a combination of antibody- and LC–MS/MS-based methods, Zhang et al. reveal lysine l-lactylation as the key lactylation isomer in cellular histones, responding dynamically to glycolysis and positively correlating with lactyl-CoA levels, providing insights into the Warburg effect.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the phosphoglucose isomerase gene PGI1, and engineering a synthetic energy system to regulate NADH/NAD⁺ ratio.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Sn doping enables a breakthrough in p-type AgSbTe₂ for thermoelectric applications, achieving a zT of 2.5 and 12.1% device efficiency. The authors reveal an impurity band mechanism, offering a strategy for AgSbTe₂ optimization.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake.

A 1/3 power law between thermal conductivity and length of a NbSe₃ nanowire is observed, pointing towards a superdiffusive heat transport regime.

Complex spikes (CSs) driven by inferior olivary neurons have crucial roles in motor control. Wang et al. identified an excitatory pathway from the cerebellar nuclei to the inferior olive that drives rapid feedback CSs and contributes to the fine control of ocular and body movements.

Non-reciprocal charge transport has potential for applications but is usually weak. Here the authors report a room-temperature divergent non-reciprocal Hall effect in devices made of Pt deposited on Si substrates.

Xiao et al. report a weaker adaptive immune response in older adults after inactivated SARS-CoV-2 vaccination compared to young adult controls, identifying altered immune cell function and decreased antigen-specific receptor repertoire diversity as potential underlying mechanisms.

Satellite records combined with global ecosystem models show a persistent and widespread greening over 25–50% of the global vegetated area; less than 4% of the globe is browning. CO₂ fertilization explains 70% of the observed greening trend.

The efficiency of lead-halide perovskite photovoltaics is related to the tolerance of their band-edge charge-carriers to point defects. Here, the authors show that this tolerance can be extended to hot carriers depending on the defect energy level.

How the brain controls movement direction, from quick steering to slow exploratory turns, remains poorly understood. Here, the authors show that two distinct brainstem circuits govern these turning patterns, highlighting a modular system that fine-tunes movement for speed and precision.

Magnetic tunnel junctions consist of two magnetic layers, separated by a thin insulator. The simplicity belies the industrial importance: magnetic tunnel junctions have a very wide variety of applications in contemporary society. Here, Fu et al present a magnetic tunnel junction composed of single van der Waals magnetic insulator, CrI3, exhibiting remarkably low power consumption.

Exchange bias occurs in a variety of magnetic materials and heterostructures. The quintessential example occurs in antiferromagnetic/ferromagnetic heterostructures and has been employed extensively in magnetic memory devices. Here, via a specific field training protocol, the authors demonstrate an exchange bias of up to 400mT in odd layered MnBi2Te4.

Several recent experimental studies have found disconnected Fermi surface arcs emerging below the Neel temperature in several rare-earth mono-pnictides. While these electronic states have been attributed to a non-collinear antiferromagnetic order, experimental evidence of this has been lacking. Here Huang et al demonstrate the emergence of non-collinear antiferromagnetic order using spin-polarized scanning tunnelling microscopy.

Manipulating the electronic properties of topological semimetals is a central goal of modern condensed matter physics research. Here, the authors demonstrate how a high-entropy engineering approach allows for the tuning of the crystal structure and the electronic states in a Dirac semimetal.

The selective degradation of mitochondria by autophagy is essential for cell homeostasis. Here, Nan et al show that the effector protein BipD, secreted by Burkholderia pseudomallei, is able to modulate host mitophagy to promote its survival.

Thin samples CrI₃ exhibit a phase transition under an applied magnetic field from layered antiferromagnetism to ferromagnetism. Here the authors observe an associated abrupt change in the magneto-Raman spectra, illustrating the sensitivity of Raman spectra to magnetic ordering.

Electronic bandwidth modulation by static pressure has been explored in several material families. Wang et al. use temperature-dependent Raman spectroscopy and density functional theory to reveal phonon-driven modulation of electronic pseudogap and density wave fluctuations in a ruthenate Ca₃Ru₂O₇.

The magnetic state of twisted double bilayers of antiferromagnetic chromium triiodide can be controlled by electrical gating, twist angle and temperature.

Tunability of the electronic properties of magnetic topological insulators is highly desired for future device applications. Here, the authors study the effect of substitutional impurities on the topological properties of Sb-doped MnBi₂Te₄ devices and uncover tunable layer-dependent electronic states.

Knowledge of the spin structure in parent compounds of unconventional superconductors is crucial for an understanding of the complex physics in these materials. Here, the authors report canted spin structure on the surface as well as on the thin film form of Fe_1+yTe, different from the bulk.

Single-layered materials such as graphene are well known, but metallic elements tend to favour three-dimensional clusters. Here the authors report the synthesis of rhodium nanosheets—a supported, single-layered metallic material with rare δ-bonding.

Metals supported on metal oxides are common heterogeneous catalysts. Here the authors show that metal/oxide interfacial sites are highly active for alcohol oxidation—independent of the particle sizes—and use this information to design inverse oxide-on-metal particles with high activity and stability.

The nonlinear Hall effect (NLHE) results in a second-harmonic transverse voltage in response to alternating longitudinal current in zero magnetic field and has so far only been observed at low temperatures in bulk materials. Here, the authors observe bulk NLHE at room temperature in the Dirac material BaMnSb₂, which will provide a large photocurrent for applications in THz detection.

The transport behaviour of strange metals is distinct from weakly interacting Fermi liquids. Now, a large thermoelectric response has been shown at the transition between those two states.