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A new Bayesian framework for analysing gravitational-wave ringdown signals from black holes speeds up multi-mode inference, enhancing rapid and statistically robust tests of strong gravity.

A generalized approach is proposed for enhancing contact-electro-catalysis (CEC) in a broader temperature window (up to 180 °C). Its feasibility is verified by CEC-leaching of spent LIB cathodes, with >90% leaching efficiency for all elements in 5 h.

External stimulus-induced cellular stress response plays a role in the development of esophageal squamous cell carcinoma (ESCC). Here the authors show that stress-induced activation of p38 MAPK leads to ACSL4 phosphorylation and Src myristoylation to promote tumorigenesis in ESCC.

A method to make a big family of non-van der Waals superlattices of carbides and carbonitrides based on the delamination and rolling-up of multilayer MXenes is presented. 

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

Chemical doping allows for boosting the conductivity in conjugated polymers but the relationship between doping and the polymers’ complex, multiscale morphology remains elusive. Here the authors report that supramolecular chirality, which up to now had not been considered a parameter relevant to doping, significantly boosts the underpinning redox reaction in conjugated polymer thin films.

Aircraft contrails are not just streaks in clear blue skies - they represent a significant source of warming from the aviation sector. Two new studies reveal that their climate impact is more complex than previously thought, as many contrails may form within existing cirrus clouds – a factor often overlooked in past assessments. Drawing on aircraft, satellite and meteorological data, Petzold et al. and Seelig et al. provide fresh insights into the occurrence frequency and the radiative properties of these often “hidden” contrails.

Single-cell RNA-sequencing of seven mouse developmental stages identifies lineage-specific and shared regulatory programs controlling cell-fate decisions. Cross-species analysis associates differentiation potency with ribosomal protein gene expression.

Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.

OBOX, PRD-like homeobox domain transcription factors (OBOX1–OBOX8), are key regulators of mouse zygotic genome activation and early embryogenesis.

Through contact-electro-catalysis (CEC), reactive oxygen species can be produced by chemically inert triboelectric materials in ball milling, enabling mechanoredox reactions with a broad selection of abundant triboelectric materials

As presented at the 2025 AACR Annual Meeting, in an ongoing first-in-human phase 1 trial of a next-generation KRAS-G12C inhibitor in patients with solid tumors, encouraging safety and response results were observed, including in patients with non-small-cell lung cancer.

Intelligent sensing technologies gain interest for the internet of things and applications that require collection and analysis of big data. Here the authors report a flexible and durable wood-based triboelectric nanogenerator for self-powered sensing in athletic big data analytics.

Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses.

Non-invasive methods to predict treatment response are urgently needed. Here in lung cancer, the authors develop a single-cell on-chip cytometry method to metabolically phenotype disseminated tumor cells, revealing metabolic heterogeneity and predictors of therapy response and survival.

Contact electro catalysis (CEC) was proposed as a novel catalytic principle that uses electron transfers during contact electrification to accelerate chemical reactions. Here the authors show even catalytically inert pristine polymers can catalyze the degradation of organic pollutant.

The authors develop an approach for enhancing the wear resistance and lubricity of metals at elevated temperatures of in oxidative environments, where traditional solid lubricants fail. By engineering surface oxidation in additively manufactured Inconel, they achieve low friction coefficients, between 0.10 and 0.32 at 600-900 °C, through the formation of a spinel-based oxide layer.

Observation of a new resonance in the 19-fluorine to 20-neon thermonuclear reaction at the China JinPing Underground Laboratory (over 2 km below ground) may provide clues to observed discrepancies in calcium production in the evolution of the first stars.

Intensive efforts are underway to develop recycling methods for spent lithium-ion batteries. Here the authors develop a mechano-catalytic approach based on contact electrification for efficient and potentially cost-effective recycling of cathode materials.

Obesity promotes tumor growth yet simultaneously increases susceptibility to PD-1-targeted cancer immunotherapy.

Though high entropy oxides have been explored as possible conversion-type negative electrodes for Li-ion batteries, the roles of the different elements remain unclear. Here the authors determine the behavior of each element during electrochemical cycling and connect it to the nanoscale structure.

Halide perovskite based light-emitting diodes attracted intensive research interest recently but the efficiency of blue diodes is much lower than the green and red ones. Here Li et al. push up the efficiency of blue diodes through composition engineering and vertical morphology control.

Syt7-dependent pancreatic insulin release is shown to be mediated by 5-IP₇ in response to parasympathetic stimulation of the GPCR M3R.

China has enacted Electric Heating Policy to substitute electricity for in-home combustion for rural residential heating. Here the authors show that this shift would greatly increase national carbon emissions by 101.69–162.89 megatons in 2015 while impeding China’s carbon mitigation process in the future.

Human motions often contain information that is useful for orthopedic/neural disease diagnosis, rehabilitation, and prevention. Here, the authors show a badge-reel-like stretch sensing device with a grating-structured triboelectric nanogenerator for joints/spine bending or stretching sensing.

Context-dependency of mammalian transcriptional elements has hindered the quantitative investigation of multigene expression stoichiometry and its biological functions. Here the authors present a host-orthogonal transcriptional system that drives tunable gene expression in mammalian cells, enabling predictive fine-tuning of multi-gene expression stoichiometry and the production optimization of virus-like particles from mammalian cells.

Here the authors elucidate the epigenetic basis underlying the activation of PVR-associated genes during RPE cell fate transitions and offers potential therapeutic avenues targeting epigenetic modulation and the RANK-NFATc1 axis for PVR management.

Microplastics interacting with cyanobacteria can alter microbial communities and functional genes, impacting carbon and nitrogen cycles in seagrass meadows and posing ecological risks, according to an in-situ incubation experiment in seagrass meadow at Swan Lake, China.

Here, the authors characterize the utilization of 20 medicinal polysaccharides by 28 human gut Bacteroides and Parabacteroides species, revealing substantial variability in bacterial growth responses, which they link to genomic differences in carbohydrate-active enzymes.

Excitonic insulators remain a topic of great interest in condensed matter physics. Here, the authors provide spectroscopic evidence of increased electronic coherence in the charge-density-wave state of semiconducting 1T-TiSe₂.

Triboelectric nanogenerators harvest energy by contacting two solids or a liquid and a solid. Here the authors use a conductive liquid membrane as a permeable electrode to demonstrate triboelectrification via liquid–liquid contact by passing liquid droplets through a liquid membrane to generate power.

The authors identify Drosophila cGLR1 as a double-stranded RNA sensor and 3′2′-cGAMP as a nucleotide second messenger and activator of Drosophila STING signalling.

Osteocytes are the key cellular components of cortical bone. Here they show that osteocytes transfer mitochondria to the endothelial cells of transcortical vessels (TCVs), which promotes angiogenesis and increases function of the TCV network.

The lack of a clean charge neutral cleavage plane for the 122 family of iron-based superconductors has complicated surface-sensitive spectroscopy probes from revealing the intrinsic electronic properties of these materials. Here the authors introduce an effective surface dosing method that drastically improves the observed spectral quality, thus revealing unprecedented details of the superconducting gap anisotropy.

Genome assembly approaches are limited by factors including cost, power and incomplete resolution. Here, the authors present Aquila, a method that uses a reference sequence and linked read data to generate high quality diploid genome assemblies from which genetic variation can be detected and phased.