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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range complex and Pol μ in association with Ku70/80 and characterize the interaction between the BRCT domains of Pol λ and μ with Ku70/80.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe₄ has only four Weyl points, the minimal number required by time-reversal symmetry.

Proposals for the realization of Weyl semimetals, topologically non-trivial materials which host Weyl fermion quasiparticles, have faced demanding experimental requirements. Here, the authors predict such a state in stoichiometric TaAs, arising due to the breaking of inversion symmetry.

Understanding the spin texture of topological insulator surface states is crucial for applications in spintronics and nanodevices. Here, Neupane et al. report systematic spin- and angle-resolved photoemission spectroscopy on ultrathin Bi₂Se₃films for the first time.

The spin-orbit interaction is central to the defining characteristics of topological insulators. Here, Jozwiaket al. report a spin-polarized unoccupied surface resonance coevolving with topological surface states from a pair of Rashba-like states through spin-orbit induced band inversion.

A superconducting material containing a topologically non-trivial electronic band structure presents the possibility of realizing Majorana states as well as exotic excitations with potential in quantum computing. Here, the authors evidence the required ingredients in the noncentrosymmetric superconductor BiPd.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Symmetry-breaking distortion on the surface of topological crystalline insulators imparts mass to Dirac electrons. The mass is shown to depend on the penetration depth of the surface states. Non-topological surface states are also reported.

What happens to correlated electronic phases—superconductivity and charge density wave ordering—as a material is thinned? Experiments show that both can remain intact in just a single layer of niobium diselenide.

In situ spectroscopic analysis of operating solid oxide electrochemical cells has proved to be difficult owing to high-vacuum requirements. Ambient-pressure X-ray photoelectron spectroscopy on single-chamber cells now suggests that surface reaction kinetics and electron transport on the electrodes are co-limiting processes.

The interplay between electronic topology and superconductivity is of great current interest in condensed matter physics. Here, the authors unveil an unconventional two-dimensional superconducting state accompanied by a van Hove singularity in the recently discovered Dirac nodal line semimetal ZrAs₂, which is exclusively confined to the top and bottom surfaces.

The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV₃Sb₅ that indicates broken symmetries and intrinsic chirality.

Transition metal dichalcogenides exhibit diverse and tunable electronic states. Here the authors reveal a cascade of phase transitions upon increasing hydrostatic pressure in the few-layer 1T’-WS₂, including a re-entrant superconducting phase emerging from a normal state exhibiting anomalous Hall effect.

Osugo et al show in healthy humans that sustained dopamine D2/D3 receptor antagonism impairs motivated behaviour, hedonic experience, and emotional expression, and that this is related to blunted striatal reward response following D2/D3 antagonism.

Climate change adaptation and sea level rise pose challenges for both natural and societal dynamics. Here the authors analyse coastal processes and socio-political dimensions of erosion, leading to maldevelopment on Fuvahmulah in the Maldives.

The pairing mechanism in kagome superconductors is still not fully understood. Now, CsV₃Sb₅, which belongs to this family, is shown to have orbital-selective pairing with two distinct superconducting domes that are not separated by any phase boundary.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

A single-cell transcriptomic analysis of 63 patients with colorectal cancer classifies tumor cells into two epithelial subtypes. An improved tumor classification based on epithelial subtype, microsatellite stability and fibrosis reveals differences in pathway activation and metastasis.

Crop production is threatening by multiple stressors. Here, the authors report the identification of a thylakoid protein encoding gene and show that knocking out this gene results in enhanced resistance to oomycete, fungi and bacteria, as well as increased tolerance to salt and drought mimics in potato.

Low cost and low power consumption of transistors are needed for the development of internet of things. Here Chung et al. develop a high performance n-type oxide thin film transistor by introducing a ligand for crosslinking nanoparticles and polymers, obtaining a near-ideal hybrid dielectric layer.

Authors analyze the associations of emergency admissions related to mental health disorders with short-term temperature changes before and during the COVID-19 pandemic, providing evidence for increased risks for depression-related visits associated with elevated temperatures during the pandemic.

The interplay of magnetism, various symmetries and correlations can lead to intriguing physics in the solid state. Here, the authors report signatures of a Hund nodal line in the antiferromagnet YMn₂Ge₂.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Topological boundary modes within charge-ordered states have not yet been observed experimentally. Now an in-gap boundary mode, stemming solely from the charge order, is visualized in the topological material Ta₂Se₈I.

Scanning tunnelling microscopy and scanning tunnelling spectroscopy have been used to observe intra-unit-cell nematic order and associated Fermi surface deformation in ScV₆Sn₆.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

A hybrid topological phase of matter is discovered in the simple elemental-solid arsenic and explored using tunnelling microscopy, photoemission spectroscopy and a theoretical analysis.