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The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.

Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.

Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core and dispensable transcriptome, and reveal conservation and divergence of gene expression balance across homoeologous subgenomes.

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassium channel blockers.

Gadolinium-neutron capture therapy (Gd-NCT) in glioblastoma shows promise but is limited by toxicity and short-half life in the brain. Here, the authors present a magnetised stem cell-nanoparticle system to facilitate brain penetrance of Gd-NCT and demonstrate its utility in an orthotopic rat glioblastoma model.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Atmospheric dryness is increasing as air temperatures rise because of climate change. This Review explores temporal trends and spatial heterogeneity in global atmospheric dryness and the implications for plant growth, productivity and terrestrial carbon cycling.

Wang, Fan, Guo, and colleagues present MorphDiff, a transcriptome-guided latent diffusion model that accurately predicts cell morphological responses to perturbations, enhancing MOA identification and phenotypic drug discovery.

The growing consumption of electronics is leading to the rapid accumulation of electronic waste, which has been a global concern for years. This work presents a closed-loop bio-recyclable cellulose-based dielectric film that can improve the circularity of electronics and could reduce electronic waste.

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

A lipid nanoparticle is used to deliver a base editor in vivo to haematopoietic stem cells in mice.

Cobalt-based subsurface dopants induce a shift in the rate-determining step of electrochemical CO₂ reduction on copper to the chemical step: OCCO* + H* → OCCHO* + *. Electrochemical production of ethylene over the optimized catalyst is achieved at low voltage and high current in a membrane electrode assembly system.

With nature in cities, as with the chemicals we ingest, the dose can make the difference. This analysis looks across other studies to find that, in practice, a moderate ‘dose’ of urban greenness provides the greatest mental health benefits.

R. Khasanov et al. report thermodynamic and muon-spin-rotation measurements on the Mo₅Si_3−xP_x superconducting family. They find that a flat band reaches the Fermi level at x ≃ 1.3, leading to enhancement of electronic correlations and an abrupt change of the superconducting properties.

This study reports the design of heterogated nanoprobes for interval-based pH imaging in biological systems, including cellular endocytic organelles and tumours. The modular design allows for fine-tuning of pH transition point and fluorescent emission.

The interaction of terahertz (THz) waves with condensed matter materials is utilised to investigate the low-energy electronic behaviours and topological properties near the equilibrium state, for example, transport characteristics of topological semimetals. Here, the THz longitudinal conductivities of high-quality Mn₃Sn epitaxial thin films are anisotropic along different crystal orientations with carrier localization behavior, which are well described by the Drude-Smith model.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

Linear scaling relationships often hinder the optimization of heterogeneous catalysts. Now, an intermediate spillover strategy is put forward by designing bi-component catalysts, thereby decoupling elementary electron-transfer steps and circumventing linear scaling relationships.

Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.

Cohort-scale integration of clinical and proteomic data from tumor tissues in patients with pancreatic ductal adenocarcinoma led to the identification of a prognostic risk model for patient stratification as well as biomarkers of response to adjuvant chemotherapy, validated in independent external cohorts.

Rapid, biocompatible, and parallel generation of microbubbles remains a major challenge despite their high potential in biomedical and materials applications. The authors introduce a low-energy, biocompatible opto-electrochemical platform that enables precise, parallel microbubble patterning for programmable assembly of nanoscale to biological materials with high spatial accuracy.

Nervous system development relies on coherent up-regulation of extensive genes in a precise spatiotemporal manner. Here, the authors show that miR-9/TTP circuitry ensures coordinated up-regulation of neuronal mRNAs in neurons and limits unscheduled accumulation of these transcripts in non-neuronal cells.

Tumor-infiltrating regulatory T (TI-T_reg) cells help tumor growth by suppressing local immune responses. Here the authors show that thonzonium bromide can help fight tumors by interfering with the interaction of p97 and Npl4, a complex that they show supports TI-T_reg cells.

Cancer cells can depend on Pol θ for survival. Here, the authors show that Pol θ typically initiates end-joining at microhomologies that contain mismatches, without requiring bidirectional synthesis. This suggests a revision of the definition of microhomology for analysis of genomic mutations.

Fast charging of high-energy batteries is limited by electrolyte instability under rising overpotential. A self-adaptive electrolyte overcomes this by dynamically expanding its stability window during charging, enabling efficient zinc- and lithium-metal battery operation.

Reverse osmosis of seawater is a popular though energy demanding process to produce freshwater. Interfacing reverse osmosis membranes with solar steam generation shows potential for a more efficient desalination process.

When entering a ferromagnet, a spin-singlet supercurrent decays rapidly, while a spin-triplet supercurrent can extend over much longer distances. Here, the authors observe long-range, spin triplet supercurrent in lateral Josephson junctions constructed using the van der Waals metallic ferromagnet Fe₃GeTe₂ as the weak link.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.

A relative potency-adjusted inventory of fine-particulate matter (PM_2.5) established in China reveals sectoral and regional disparities in PM_2.5 emissions, exposures and associated toxic potencies.

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Preliminary results from a phase 1/2 trial with 18-month follow-up show that transplantation of CRISPR–Cas9 BCL11A-edited autologous hematopoietic cells in two children with β-thalassemia was safe and achieved transfusion independence.

The stability of perovskite tandem solar cells is an issue. Li et al. show that diamines improve the compositional homogeneity of a low-bandgap perovskite surface and form a low-dimensional barrier that passivates defects, leading to an operational stability of over 1,000 h.

Here, the authors explore the mechanism of the monkeypox virus E5 protein using cryo-EM, and delineate the E5-mediated DNA unwinding initiation model in terms of dsDNA loading, melting and ssDNA translocation.

Olefins are employed in many coupling procedures but direct hydrocarbonations of unactivated olefins remain to be developed. Here, the authors report the nickel-catalyzed reductive coupling of olefins with aryl and alky electrophiles under mild conditions and with a broad substrate scope.

He et al. report a two-transistor-two-resistor core unit based synaptic kernel with monolithic 3D heterogeneous integration compatibility, showing compelling performance, yield (91.2%), and component uniformity. Synaptic kernel supporting differential weight achieves beyond 85% CIFAR-10 recognition.

Land plants diverged from streptophyte algae around 460 million years ago. Marine Charophyceae fossils from the Upper Ordovician confirm that morphological innovations key to the evolution of terrestrial flora predate the emergence of land plants.