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This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

This study screens microorganisms that have genetic potential for extracellular electron transfer capabilities in anaerobic wastewater treatment.

Abiotic methylation triggered by plastic debris can occur independently of light conditions and therefore drive methylmercury formation in dark waters, according to an experimental study combined with density functional theory calculations.

Highly stretchable organic light-emitting diodes tend to suffer from a lack of mechanical robustness. Here, Yin et al. fabricate ordered buckled films by laying flexible light-emitting diodes on laser-ablated, prestretched substrates. The devices exhibit good emission stability over 15,000 stretching cycles.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

This work demonstrates super colossal barocaloric effect in one of the “simplest” materials—H₂O, with a reversible entropy change as much as 728 J·kg^-1·K^-1 under a small pressure 0.1 GPa by adding a little amount of GdCl₃. Neutron combined with molecular dynamics simulations revealed the mechanism and inferred that H-bond engineering can be an attractive approach for designing novel caloric materials.

This study identifies a regulatory module in which UBC32 and SC35 regulate bZIP49 splicing to maintain potassium balance, revealing how poplar adapts to salt stress and providing new insights into plant responses to soil salinity.

Stimuli-responsive single-component multi-emissive materials offer unique advantages in photoluminescence. Single-component multi-emissive materials with stimuli-responsive properties offer unique advantages in the field of multicolor-tunable photoluminescence.

Using data from six population-scale cohorts involving more than 10 million individuals, a large language model-based aging signature is shown to outperform traditional aging biomarker indices and signatures in predicting multiple health outcomes, at general and organ-specific levels.

Diatomic catalysts show promise for the oxygen reduction reaction, but their complex kinetics hinder rational design. Here, the authors synthesize strongly bonded Fe-Co diatomic catalysts where Co acts as the main active site and Fe aids *OH adsorption, revealing a synergistic effect.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

Currently, there is limited understanding of the molecular subtypes of fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Here, the authors employ integrated genomics and transcriptomics to develop a CpG site-specific methylation signature for the identification of FH-deficient RCC, and to identify three distinct molecular subtypes for this rare but highly lethal kidney cancer.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

Certain chiral macroions have previously been shown to self-assemble into spherical structures. Here, the authors observe self-sorting of racemic macroions into enantiomeric ‘blackberry’-shaped structures, and furthermore show that the addition of chiral co-anions allows the formation of a single enantiomer.

BPAN is a rare neurodegenerative disease caused by WDR45 mutations. Here, the authors discover that WDR45 can competitively displace G3BP1 from Caprin-1 to promote stress granule disassembly, a function that is disrupted by BPAN-associated WDR45 mutations.

Pressure treatment can modify the luminescence properties of materials. Here the authors use pressure to turn nonemissive organic zinc halide perovskites bright with full color tunability, which enables robust optical anti-counterfeiting applications.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

One of the most efficient method to access chiral poly-substituted pyrrolidines is the catalytic asymmetric 1,3-dipolar cycloaddition, but using this reaction with weakly activated alkenes remains elusive. Here, the authors disclose a copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and 1,3-enynes.

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

The authors reveal that interfacial dead layers in ferroelectric ScAlN originate from nitrogen vacancies and strain, highlighting their critical role in unlocking the full potential of nitride ferroelectrics for advanced device architectures.

Naphthalene is a challenging arene towards transition-metal-catalyzed dearomative difunctionalization. Here, the authors show that naphthalene may act as a masked conjugated diene in palladium-catalyzed dearomative 1,4-diarylation or 1,4-vinylarylation via a tandem Heck/Suzuki sequence.

The authors find that the dielectric performance of capacitors will be significantly overestimated due to the influences of fringing effect and parasitic capacitance. Methods to solve the problem are proposed to ensure measurement validity.

Geodynamic modeling shows that large thermochemical basal mantle structures, known as LLSVPs, move much slower than the surrounding mantle, supporting their long-term stability comparable to the geological time scale of several hundred million years.

Snakes have many characteristics that distinguish them from their relatives. Here, Yin et al. sequence the genome of the five-pacer viper, Deinagkistrodon acutus, and use comparative genomic analyses to elucidate the evolution of transposable elements, developmental genes and sex chromosomes in snakes.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

To increase the efficiency, brightness and stability of next-generation light-emitting diodes (LEDs), the microstructure of CsPbI_3-xBr_x metal-halide perovskite, a good pure-red emitter, was altered to fix hole leakage, which was identified as decreasing efficiencies in overworked LEDs.

Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Crystalline dispersoids are commonly used to strengthen metals by obstructing dislocation movement, but this often comes at the cost of ductility. Here, the authors demonstrate that amorphous nanoparticles, introduced via additive manufacturing, enhance both the tensile strength and fatigue resistance of metallic materials.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Bound states in the continuum are merged in momentum space by varying the periodicity of the photonic crystal lattice, giving high-quality-factor guided resonances that are robust to out-of-plane scattering.

Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

The feasibility of satellite-assisted quantum communication is demonstrated by a field test on the ground. To supress noise due to sunlight the wavelength of 1,550 nm is chosen, and spectrum and spatial filtering technology developed.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

The record-breaking atmospheric methane growth rates in 2020 and 2021 revealed heightened emissions from inundated areas in tropical Africa and Asia. However, current processed-based wetland models fail to capture emission surges in these regions.

Exciton transport in 2D Ruddlesden−Popper perovskite plays a key role for their optoelectronic performance. Here, authors significantly enhance free exciton mobilities in exfoliated thin flakes by anchoring butyl ammonium cation with polymethyl methacrylate, which also improves lattice rigidity.