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Showing 1–50 of 61 results

Advanced filters: Author: Chen-Yu Li Clear advanced filters

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Junyi Ju
Aiping Chen
Quan Zhao
ResearchOpen Access13 Oct 2017
Nature Communications

Volume: 8, P: 1-14
Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems

With redox-linked synthetic biology and electrobiofabrication, electronic information can be transmitted in a bidirectional manner between biology and electronics. Here the authors design an electrogenetic platform that allows real time electronic control of biological functions from proteins and gene circuits to cell consortia.

Sally Wang
Chen-Yu Chen
William E. Bentley
ResearchOpen Access21 Dec 2023
Nature Communications

Volume: 14, P: 1-17
Integration of humanized ROBO1 CAR in PD-1 locus in natural killer cells delivers synergistic tumor-killing effect against non-small cell lung cancer

Jia-Hao Tao
Jun Zhang
Cha-Xiang Guan
Research05 Sept 2025
Cancer Gene Therapy

P: 1-17
Survival comparison of breast conserving therapy and mastectomy with breast reconstruction for breast cancer using propensity score matched cohort

Hao Li
Shen Tian
Ling-quan Kong
ResearchOpen Access19 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
A ring-like accretion structure in M87 connecting its black hole and jet

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Ru-Sen Lu
Keiichi Asada
Chen-Yu Yu
ResearchOpen Access26 Apr 2023
Nature

Volume: 616, P: 686-690
Author Correction: Support-free iridium hydroxide for high-efficiency proton-exchange membrane water electrolysis

Yubo Chen
Chencheng Dai
Zhichuan J. Xu
Amendments and CorrectionsOpen Access26 Jun 2025
Nature Communications

Volume: 16, P: 1
Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

Circulating factors have an important role in aging. Here the authors show that small extracellular vesicles derived from young plasma rejuvenate whole-body physiology in aged mice, at least in part, by stimulating PGC-1α expression and improving mitochondrial energy metabolism.

Xiaorui Chen
Yang Luo
Xi Chen
ResearchOpen Access16 Apr 2024
Nature Aging

Volume: 4, P: 814-838
Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

Active enhancers are still understudied in colorectal cancers (CRC). Here the authors analyse active enhancers in CRC patients using genomics, transcriptomics, and epigenomics, identifying and validating variant super-enhancer loci as well as KLF3 as a relevant transcription factor.

Qing-Lan Li
Xiang Lin
Min Wu
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice

During cold exposure, activated brown adipose tissue takes up a large amount of circulating glucose to fuel thermogenesis. Here, the authors show that cold stress enhances the packaging of miR-378a-3p into BAT-derived EVs, which are delivered to the liver and consequently stimulates gluconeogenesis.

Jinhong Xu
Le Cui
Xiaohong Jiang
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-19
Organic–inorganic covalent–ionic network enabled all–in–one multifunctional coating for flexible displays

Lin et al. report a nanoscale organic-inorganic covalent-ionic hybrid network leveraging the reorganising interaction between siloxanes and fluoride ions, enabling a single layer coating with excellent optical, antistatic, anti-smudge, anti-scratch, and mechanical properties for touch displays.

Xiong Lin
Chen–Yu Li
Qiang Fu
ResearchOpen Access08 Nov 2024
Nature Communications

Volume: 15, P: 1-12
A synthetic enzyme built from DNA flips 10⁷ lipids per second in biological membranes

Mimicking enzyme function and improving upon it is a challenge facing nanotechnology. Here the authors design a DNA nanostructure that catalyzes the transport of lipids between bilayers at a rate three orders of magnitude higher than biological enzymes.

Alexander Ohmann
Chen-Yu Li
Aleksei Aksimentiev
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-9
Support-free iridium hydroxide for high-efficiency proton-exchange membrane water electrolysis

Next-generation proton exchange membrane electrolyzers rely on high-performance anodes. Here, the authors report a metal-oxide-based molecular self-assembly strategy toward a support-free iridium hydroxide catalyst for an advanced anode with low-iridium loading and enhanced mass transport.

Yubo Chen
Chencheng Dai
Zhichuan J. Xu
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-10
Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung-Mu Yang
I-Hsuan Alan Chen
Hsin-Chih Yeh
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways

Chen-li Zhang
Chan-yuan Zhao
Min Li
ResearchOpen Access20 Jun 2025
Oncogenesis

Volume: 14, P: 1-13
Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16

Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16.

Hanying Ding
Shasha Zheng
Xiaohong Jiang
ResearchOpen Access31 May 2016
Nature Communications

Volume: 7, P: 1-17
Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Exosomes, vesicles secreted by cancer cells, have a role in cancer progression but the mechanisms regulating their biogenesis are mostly unknown. Here the authors show that PKM2, a rate-limiting glycolytic enzyme overexpressed in cancer cells, mediates exosomes exocytosis by phosphorylating SNAP-23.

Yao Wei
Dong Wang
Ke Zen
ResearchOpen Access09 Jan 2017
Nature Communications

Volume: 8, P: 1-12
The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study

Kai Du
Yong-Li Zuo
Shu-Ming Li
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-16
Circulating human cytomegalovirus-encoded HCMV-miR-US4-1 as an indicator for predicting the efficacy of IFNα treatment in chronic hepatitis B patients

Yi Pan
Nan Wang
Ke Zen
ResearchOpen Access10 Mar 2016
Scientific Reports

Volume: 6, P: 1-8
Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus Cyathus africanus

Rong-Wei Kou
Shuang-Tian Du
Jin-Ming Gao
Research16 Oct 2018
The Journal of Antibiotics

Volume: 72, P: 15-21
Predictive factors of postoperative infection-related complications in adult patients with cerebral cavernous malformations

Chen-Yu Ding
Bao-Qiang Lian
De-Zhi Kang
ResearchOpen Access21 Jan 2020
Scientific Reports

Volume: 10, P: 1-7
Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

Chiao-Wen Kang
Avijit Dutta
Chun-Yen Lin
ResearchOpen Access23 Oct 2015
Scientific Reports

Volume: 5, P: 1-12
Compound 38, a novel potent and selective antagonist of adenosine A_2A receptor, enhances arousal in mice

Hui Zhang
Wei-xiang Ma
Yi-qun Wang
Research08 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1177-1189
Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer: a pooled pharmacometrics analysis

Hao-ran Dai
Yang Yang
Zheng Jiao
Research17 May 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2212-2225
Regulation of KDM5C stability and enhancer reprogramming in breast cancer

Qiong Xiao
Chen-Yu Wang
Min Wu
ResearchOpen Access03 Oct 2022
Cell Death & Disease

Volume: 13, P: 1-13
Deconstruction the feedforward inhibition changes in the layer III of anterior cingulate cortex after peripheral nerve injury

Injury-induced changes in MD-to-L3 projections, leading to increased feed forward inhibition, contribute to both pain aversion and altered pain thresholds. Manipulating these inputs affects pain-related behaviors, highlighting their role in pathological pain.

Yan-Na Lian
Xiao-Wen Cao
Xiang-Yao Li
ResearchOpen Access01 Oct 2024
Communications Biology

Volume: 7, P: 1-13
Population pharmacokinetics of the anti-PD-1 antibody camrelizumab in patients with multiple tumor types and model-informed dosing strategy

Chen-yu Wang
Chang-cheng Sheng
Zheng Jiao
Research05 Nov 2020
Acta Pharmacologica Sinica

Volume: 42, P: 1368-1375
Application of metabolomics in urolithiasis: the discovery and usage of succinate

Xiu-zhen Zhang
Xiong-xin Lei
Hui-qi Xie
ResearchOpen Access21 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-13
Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

Yuchen Liu
Dameng Li
Chen-Yu Zhang
ResearchOpen Access03 Dec 2015
Scientific Reports

Volume: 5, P: 1-10
Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma

Jialu Li
Yang Liu
Yi Ba
ResearchOpen Access07 Aug 2015
Scientific Reports

Volume: 5, P: 1-13
Redox active plant phenolic, acetosyringone, for electrogenetic signaling

Fauziah Rahma Zakaria
Chen-Yu Chen
William E. Bentley
ResearchOpen Access26 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Impact of pneumococcal conjugate vaccination on hospitalized childhood pneumonia in Taiwan

Jian-Te Lee
Jou-Wei Lin
Li-Min Huang
Research22 Dec 2021
Pediatric Research

Volume: 92, P: 1161-1167
Intestinal epithelial PKM2 serves as a safeguard against experimental colitis via activating β-catenin signaling

Xinlei Sun
Li Yao
Ke Zen
Research28 Aug 2019
Mucosal Immunology

Volume: 12, P: 1280-1290
SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs

Qun Chen
Fan Zhang
Chen-Yu Zhang
ResearchOpen Access17 Aug 2020
Cell Research

Volume: 31, P: 247-258
MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity

Jun-Yi Zheng
Chen-Yu Wang
Lian-Yun Li
ResearchOpen Access06 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-13
A high-quality chromosome-level genome assembly of the endangered tree Kmeria septentrionalis

Chen-Yu Shi
Guo-Le Qin
Li-Xia Gao
ResearchOpen Access13 Jul 2024
Scientific Data

Volume: 11, P: 1-9
Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival

Hongwei Gu
Chihao Zhao
Ke Zen
ResearchOpen Access24 May 2017
Scientific Reports

Volume: 7, P: 1-12
Slug-upregulated miR-221 promotes breast cancer progression through suppressing E-cadherin expression

Yi Pan
Jing Li
Hongwei Gu
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-14
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

Zheng Fu
Xiang Zhang
Xi Chen
ResearchOpen Access29 Mar 2021
Cell Research

Volume: 31, P: 631-648
Comprehensive Evolutionary Analysis of the Major RNA-Induced Silencing Complex Members

Rui Zhang
Ying Jing
Donghai Li
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-7
Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis

Chaoyun Pan
Dihan Zhu
Ke Zen
ResearchOpen Access24 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2

Xihan Li
Zheng Fu
Chen-Yu Zhang
ResearchOpen Access12 Jan 2018
Cell Research

Volume: 28, P: 157-171
Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system

Rui Tang
Limin Li
Ke Zen
Research23 Aug 2011
Cell Research

Volume: 22, P: 504-515
Human SIDT1 mediates dsRNA uptake via its phospholipase activity

Cai-Rong Sun
Da Xu
Cong-Zhao Zhou
Correspondence06 Nov 2023
Cell Research

Volume: 34, P: 84-87
Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions

Zhen Bian
Li-Min Li
Ke Zen
Correspondence24 Aug 2010
Cell Research

Volume: 20, P: 1076-1078
Recent advances in the pathogenesis and prevention strategies of dental calculus

Yu Wei
Gao-peng Dang
Li-na Niu
ReviewsOpen Access13 Jul 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-10
microRNAs in aged sperm confer psychiatric symptoms to offspring through causing the dysfunction of estradiol signaling in early embryos

Gaoli Liang
Xiaoju Zhu
Xi Chen
CorrespondenceOpen Access05 Jul 2022
Cell Discovery

Volume: 8, P: 1-5
Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

Zhen Zhou
Xihan Li
Chen-Yu Zhang
ResearchOpen Access07 Oct 2014
Cell Research

Volume: 25, P: 39-49
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

Xi Chen
Yi Ba
Chen-Yu Zhang
Research02 Sept 2008
Cell Research

Volume: 18, P: 997-1006
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

Yuan Yin
Xing Cai
Chen-Yu Zhang
ResearchOpen Access16 Sept 2014
Cell Research

Volume: 24, P: 1164-1180
Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products

Xi Chen
Chao Gao
Chen-Yu Zhang
Research15 Jun 2010
Cell Research

Volume: 20, P: 1128-1137

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