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Organ metabolic crosstalk is vital but challenging to trace. Here, the authors present MSITracer, a computational tool for spatial isotope tracing that reveals inter-organ crosstalk, such as liver–heart fatty acid metabolism and lung-derived glutamine catabolism in tumors.

A microchip-based DNA synthesis method enables scalable production of complex DNA constructs.

Generalizable Pathology Foundation Model (GPFM) consolidates expertise from a variety of existing models for use in a broad spectrum of computational pathology tasks.

Understanding the pathophysiological pathways of mental disorders and identifying reliable biomarkers remain challenging. This study introduces a large-scale knowledge graph tailored to mental disorders to improve knowledge discovery, disease prediction, and clinical validation

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

All-solid-state batteries are potentially superior to Li-ion batteries, but to maximize performance, the solid electrolyte needs to be compatible with high-performance anodes. Halide solid electrolytes are shown to possess dynamic stability that extends beyond the electrochemical stability window, allowing improved full-cell performance.

An ongoing effort aims to transform the clonally propagated tetraploid potato to a seed-propagated diploid crop, but our understanding of it disomic inheritance is limited. Here, the authors report genetic basis of heterosis in the elite hybrid potato and identify a male fertility-related PME gene with dominance heterotic effect.

An analysis of single-cell RNA sequencing data from adult and developing lungs across vertebrate species reveals genetic components in the common ancestor of jawed vertebrates and new lung-specific enhancers that contribute to the evolution of vertebrate lungs.

This study introduces a ChickenGTEx atlas of regulatory variants across 28 tissues and illustrates its utility in deciphering association signals for 39 complex traits in chickens.

A natural mutant of maize exhibits leaf characteristics in line with the ‘smart canopy’ ideotype for high-density planting and boosts yields in large-scale field trials.

Platelet-activating factor (PAF) and PAF-like phospholipids were identified as propagators of ferroptosis, whereas PAFAH2 suppressed synchronized ferroptosis and, thus, prevented tubular cell death in acute kidney injury.

The selective degradation of mitochondria by autophagy is essential for cell homeostasis. Here, Nan et al show that the effector protein BipD, secreted by Burkholderia pseudomallei, is able to modulate host mitophagy to promote its survival.

Samples from the Chang’e-6 mission show that the lunar magnetic field rebounded in field strength after its previous sharp decline of about 3.1 Ga.

Here the authors develop an iterative particle sieving method called CryoSieve, demonstrating this method outperforms other cryo-EM particle sorting algorithms to reveal that most particles are unnecessary in final stacks.

A damage-free transfer printing method utilizing localized molten gallium enables the precise manipulation of fragile micro- and nano-films. The method offers adhesion regulation and reliability that cannot be easily achieved by fully liquefied stamps.

Intermediate soil acidification alters the denitrifier community composition and induces high nitrous oxide (N₂O) emissions, which contributes to the observed acceleration of N₂O emissions from global soils

Reducing membrane thickness to nanometre scale should increase the throughput of gas separation sieves. Here, the authors report a sieving membrane composed of two-dimensional metal-organic framework nanosheets, exhibiting both high permeation flux and thermally switchable behaviour.

Predicting TCR–antigen–human leucocyte antigen binding opens the door to neoantigen identification. In this study, a physics-inspired sliding transformer (PISTE) system is used to guide the positioning of amino acid residues along the gradient field of their interactions, boosting binding prediction accuracy.

The authors report three palaeomagnetic poles from the North China craton and document a large round-trip true polar wander oscillation during 155−141 Ma that may have affected biotic evolution in East Asia and global extinction and endemism.

Comparative analysis of single-cell data from the amphioxus hepatic caecum and the liver of several vertebrates shows how genome duplication contributes to cellular diversification and functional complexity of the vertebrate liver.

The design and optimization of a metasurface is a computationally- and time-consuming effort. Here, the authors propose a neural network-based algorithm for functional metasurface design, and demonstrate it for some functional metasurfaces.

Analysing the genome of a snailfish from the Mariana Trench, the authors show genetic changes associated with unique morphological and physiological adaptations to life in the hadal zone.

Mesozoic deformation of the North China Craton occurred via lithospheric thickening followed by thinning and extension triggered by flat-slab subduction and rollback, according to four-dimensional mantle flow models of the plate–mantle system.

Designing efficient light-emitting diodes with white-light-emission from broadband-emission metal halides remains a challenge. Here, the authors demonstrate bright and efficient lead-free LEDs based on cesium copper halides enabled by introducing Tween organic additive in the precursor.

Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.

Hippo and TGF-β are crucial signalling pathways involved in the development of various types of tumours. Here, the authors demonstrate that TGF-β can directly regulate Hippo pathway through the stabilization of the scaffold protein Zyxin, which forms a ternary complex with Siah2 and Lats2 promoting Lats2 degradation and YAP activation.

Smoking-associated DNA methylation changes in whole blood have been reported by many EWAS. Here, the authors use a cell-type deconvolution algorithm to identify cell-type specific DNA methylation signals in seven EWAS, identifying lineage-specific smoking-associated DNA methylation changes.

Solar eruptions provide opportunities to study magnetic flux ropes, a structure of fundamental importance for both plasma physics and space weather. Here the authors reveal the dynamic formation of a flux rope through its footprint on the solar surface, revealing a highly twisted core structure.

Wu and colleagues report that under hypoxic conditions the LATS2 kinase is targeted for degradation by the SIAH2 ubiquitin ligase, leading to inhibition of the Hippo kinase cascade and activation of YAP, which promotes tumour growth.

A deep learning approach that predicts high-resolution maps of rare conformations in cryo-EM by constructing a self-supervised pseudo-trajectory between density maps of varying resolutions.