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Here, the authors show that KDM2A regulates cell cycle progression, modulation of H3K36me2 and H3K27me3 chromatin states and gene repression which are critical for survival of differentiating spermatogonia. KDM2A regulates progression through meiosis as well.

The bombardment of structural metals in nuclear reactors by high-energy particles causes them to develop defects, such as stacking-fault tetrahedra defects, that are difficult to cure. Yu et al.find that in nanotwinned silver such defects can be removed at room temperature by the propagation of mobile twin boundaries.

Barium tagging is a key ingredient for future detectors of neutrinoless double beta decay in low-background environments. Here, the authors demonstrate fluorescence imaging of single Ba2+ ions in high pressure Xenon gas, by comparing activity between Ba2+ chelated and unchelated samples of crown-ether chemosensors.

The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—two key adaptations that underlie bipedalism.

Human oral carcinoma cells expressing high levels of the fatty acid receptor CD36 initiate metastasis in mouse models, and metastasis is increased by palmitic acid or a fatty diet and decreased by blockade of CD36.

Saturn’s moon Titan may have an active dust cycle in equatorial regions driven by storm winds, Cassini observations consistent with dust suspension in Titan’s atmosphere suggest.

Deep optical imaging of a close quasar pair reveals a filamentary connection between them, providing insight into the transition between intergalactic and circumstellar media and a test of the cold-dark-matter cosmological theory.

Here, the authors show brightening of dark excitons by strong coupling between cavity photons and high energy, spin-allowed, bright excitons in monolayer WSe₂. In this regime, the commonly observed photoluminescence quenching stemming from the fast relaxation to the dark ground state is prevented.

The surface of Mars exhibits intriguing outcrops of layered Fe sulfate minerals that transformed through heating. This study combines lab analyses and remote sensing at Mars to advance the understanding of active chemistry and geothermal processes.

Boosting conversion efficiency, coherence and spectral bandwidth of optical signals generated in integrated photonic devices is an important current challenge. Here, the authors present their observations of two-colour dissipative solitons, breathers and frequency combs resulting from second-harmonic generation in lithium-niobate ring microresonators.

A quantum simulator can follow the evolution of a prescribed model, whose behaviour may be difficult to determine. Here, the emergence of magnetism is simulated by implementing a quantum Ising model, providing a benchmark for simulations in larger systems.

Using ultrafast electron diffraction and deflectometry, the study tracks polarization and structural dynamics in NbOI₂ nanocrystals with femtosecond resolution, revealing coherent phonon generation and polarization enhancement after UV irradiation.

Identifying intermediates during phase transitions is critical for our understanding of correlated materials, but difficult to achieve experimentally. Here, the authors report a surface coordination route to stabilize and directly image a phase-transition intermediate during the metal-insulator transition in vanadium dioxide.

High-pressure deformation experiments on hydrated polymineralic rocks show that fluid-assisted reactions are key to the formation and long-term evolution of plate boundaries, particularly in subduction zones.

Mapping the 158 μm line of ionized carbon within the Cygnus region with the SOFIA observatory provides evidence for dynamic interactions between molecular clouds and their atomic envelopes, which trace out the assembly process of cloud complexes.

Introducing plasma seeds, 3D ultrafast laser writing inside silicon reaches a new performance level. The researchers showcase a method that enables precise and reversible modifications, opening the door to monolithic memory technologies and reconfigurable optical devices.

Two high-redshift post-starburst galaxies are in the process of quenching, although their quasars remain active, indicating the complex co-evolution between black hole activity and star formation.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A combination of measurements from the Solar Dynamics Observatory and radiospectroscopy data from the Nançay Radioheliograph now details the mechanism that connects coronal mass ejections from the sun and the acceleration of particles to relativistic speeds. A spatial and temporal correlation between a coronal ‘bright front’ and radio emissions associated with electron acceleration demonstrates the fundamental relationship between the two.

To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. MCheM enables feature-resolved chemical tagging across complex mixtures, which provides orthorgonal chemical information about unknown metabolites.

Gangliosides play crucial roles in the nervous system, with aberrant metabolism linked to diseases like cancer and neurodegeneration, but tools to visualize and detect gangliosides remain limited and non-specific. Here, the authors introduce MM-JH-2, a dual fluorescent and Raman-active probe, enabling specific ganglioside labeling and differentiation between cells that differ in ganglioside biosynthetic flux.

Genetically-encoded indicators with more red-shifted excitation and emission wavelengths are advantageous for in vivo imaging. Here, Dalangin et al. report the engineering of far-red fluorescent Ca2+ indicators and demonstrate their utility for monitoring of all-optical cardiac pacing in embryonic zebrafish.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Using an advanced imaging system called EyeRIS, locomotion in deep-sea octopuses could be studied, revealing simplified crawling patterns that could inspire the design of robots.

Spatially resolved JWST spectroscopy of a massive, quiescent galaxy at a redshift of ~4 reveals that it formed its stars and quenched rapidly, despite being surrounded by an abundant gas reservoir and gravitationally bound to a star-bursting companion.

Excited state dynamics of alloyed quantum dots differ from that of binary quantum dots. Here, the authors use femtosecond spectroscopy and theoretical calculations to show that alloying tunes relaxation dynamics separately from traditional optical properties of quantum dots.

Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously unknown mechanism for precise perceptual timing.

Li et al. characterize overlapping and divergent metabolic requirements of human and murine NK cells in response to activation, with a focus on serine metabolism

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Here they generate endogenous optogenetic RhoGEFs and use them to quantitatively direct and study epithelial furrowing via cell shortening, uncovering design principles for morphogenetic furrowing including a role for tissue mechanics in furrow asymmetry.

Single-shot readout of optically active spin qubits is typically limited by low photon collection rates and measurement back-action. Here the authors overcome these limitations by using an open cavity approach for single-shot readout of a semiconductor quantum dot and demonstrate record readout time of a few ns.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

A three-dimensional culture system enables sequential differentiation of induced pluripotent stem cells into cells of the jawbone.

Tamm states on subwavelength, reconfigurable plasmonic crystals are studied in the terahertz regime. By introducing an independently controlled plasmonic defect, an electromagnetically induced transparency phenomenon is revealed.

By investigating the paradoxical retention of a photolyase gene in a light-deprived blind cavefish, the authors reveal a novel light-independent function for CPD photolyase in the repair of oxidative stress-induced DNA damage

The emergence of quantum emitters in 2D materials has led to the quest for methods and designs enabling their controllable spatial positioning. Here, the authors use strain engineering to fabricate a deterministic array of quantum emitters in WSe₂with nanometre positioning accuracy.

The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood feeding increases earlier dengue virus dissemination, the inhibitory effects of Wolbachia remain strong, highlighting Wolbachia’s potential to disrupt dengue transmission under natural feeding conditions.

Microdisplays for the glasses and headsets used in augmented reality and virtual reality must provide high pixel density, brightness and contrast, and fast response times. This Perspective explores three advanced technologies — liquid crystal on silicon, organic light-emitting diodes on silicon, and light-emitting diodes on silicon — that can meet the challenge.

Yttrium iron garnet is a ferrimagnetic insulator which demonstrates robust photon-spin coupling in hybrid microwave cavity systems. Here, the authors demonstrate a magnon gradient memory based on the dark modes of a strongly-coupled system of multiple yttrium iron garnet spheres.

Anomalously specular radar reflections (ASRR) from Titan’s tropical region were interpreted earlier as evidence for liquid surfaces, but the Cassini spacecraft did not observe lakes/seas at the anomalously specular locations. Here, the authors show that ASRR originate from one terrain unit, likely paleolakes/paleoseas.

The role of glutamate-driven inhibition in neural computations and animal behavior is not fully understood. This study reveals that group III metabotropic glutamate receptors (mGluRs) mediate inhibition in the habenula, shaping sensory processing and defensive behaviors, highlighting a key role for glutamate-driven inhibition in the brain.

Motion vision in many animals is split into pathways for bright (ON) and dark (OFF) edges, driven by luminance changes. Here the authors show how in Drosophila color selectively contributes to ON-motion, enhancing detection of saliently colored objects.