Nature Search

Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure

Heart failure can be caused by cardiac fibroblasts replacing myocytes. Here, the authors use functional genomic data from fibroblasts, genetic signals enriched in people with heart disease, and gene perturbation analyses to link disease-associated regulatory elements to protein-coding genes.

Richard Gill
Daniel R. Lu
Yi-Hsiang Hsu
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Author Correction: Individual and city-level variations in heat-related road traffic deaths in Latin America

Cheng-Kai Hsu
D. Alex Quistberg
Daniel A. Rodríguez
Amendments and Corrections09 Oct 2025
Nature Cities

P: 1
Biophysics-based protein language models for protein engineering

Mutational effect transfer learning (METL) is a protein language model framework that unites machine learning and biophysical modeling. Transformer-based neural networks are pretrained on biophysical simulation data to capture fundamental relationships between protein sequence, structure and energetics.

Sam Gelman
Bryce Johnson
Philip A. Romero
ResearchOpen Access11 Sept 2025
Nature Methods

Volume: 22, P: 1868-1879
Individual and city-level variations in heat-related road traffic deaths in Latin America

Extreme heat in Latin America increases road traffic mortality risks, with motorcyclists and bicyclists facing a 27% higher risk on the hottest days. Urban protection measures for vulnerable commuters in cities in the Global South are critical as climate change intensifies heat exposure.

Cheng-Kai Hsu
D. Alex Quistberg
Daniel A. Rodríguez
Research15 Sept 2025
Nature Cities

Volume: 2, P: 897-906
ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

Hsu, Wang, Manne et al. identify ALDH4A1 as a component of the mitochondrial pyruvate carrier complex, which plays a non-canonical role in regulating pyruvate homeostasis in mitochondria, TCA cycle entry and tumour suppression.

Che-Chia Hsu
Chi-Yun Wang
Hui-Kuan Lin
Research12 May 2025
Nature Cell Biology

Volume: 27, P: 847-862
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Rapid polymer transport in concentrated solutions through the formation of ordered structures

B. N. Preston
T. C. Laurent
G. J. Checkley
Research09 Oct 1980
Nature

Volume: 287, P: 499-503
A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types

Spatial transcriptomic approaches often lack single-cell resolution and read coverage. Here, we introduce spatial ISOform sequencing (Spl-ISO-Seq) which optimizes the capture of long, exonic molecules. This technology reveals developmentally-regulated cell-type and region-specific splicing patterns.

Careen Foord
Andrey D. Prjibelski
Hagen U. Tilgner
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Enhancing diesel engine efficiency with waste cooking oil biodiesel and nano additives for sustainable fuel applications

Haiter Lenin Allasi
Amala Justus Selvam
Sujin Jose Arul
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-17
Biological Activities of Some α-Dithiosemicarbazones

P. A. BARRETT
ELIZABETH BEVERIDGE
J. K. H. WILDE
Research26 Jun 1965
Nature

Volume: 206, P: 1340-1341
Transparent displays enabled by resonant nanoparticle scattering

Transparent displays find increasing use in a variety of applications that project information to a viewer. Here, Hsu and colleagues realize a transparent display that uses nanoparticles for a wavelength-selective scattering of incoming light.

Chia Wei Hsu
Bo Zhen
Marin Soljačić
Research21 Jan 2014
Nature Communications

Volume: 5, P: 1-6
Effect of Oxygen in Mammalian Cells Sensitized to Radiation by Incorporation of 5-Bromodeoxyuridine into the DNA

R. M. HUMPHREY
W. C. DEWEY
A. CORK
Research20 Apr 1963
Nature

Volume: 198, P: 268-269
Performance and emission characteristics of waste cooking oil biodiesel blends in sustainable fuel applications

J. Mohammed Azarudeen
M. Anish
S. Baskar
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-17
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity

Chronic alcohol use in humans and mice downregulates small intestinal mAChR4 and reduces goblet-cell-associated antigen passage formation, disrupting antimicrobial immunity.

Cristina Llorente
Fernanda Raya Tonetti
Bernd Schnabl
Research20 Aug 2025
Nature

Volume: 646, P: 180-189
Defining the cell and molecular origins of the primate ovarian reserve

Wamaitha and colleagues used the rhesus macaque to characterize the transcriptional and spatial mechanisms underlying ovarian reserve formation in prenatal life providing insights into the molecular processes governing ovarian follicle establishment.

Sissy E. Wamaitha
Ernesto J. Rojas
Amander T. Clark
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Clinical impact of pharmacogenetic risk variants in a large chinese cohort

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Chun-Yu Wei
Ming-Shien Wen
Pui-Yan Kwok
ResearchOpen Access09 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Biosynthetic Labelling of Mammalian Insulins in vitro

K. W. TAYLOR
D. G. PARRY
G. HOWARD SMITH
Research12 Sept 1964
Nature

Volume: 203, P: 1144-1145
Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research13 Feb 2023
Nature Immunology

Volume: 24, P: 412-413
Myxomatosis and the Rabbit Flea

PAUL J. CHAPPLE
N. D. LEWIS
Research24 Jul 1965
Nature

Volume: 207, P: 388-389
Expression of p53 gene in hepatocellular carcinomas induced by aflatoxin B1 with or without human hepatitis B virus in tree shrews

Jianjia Su
Guozhong Qin
Prabhakar D Lotlikar
ResearchOpen Access01 Sept 1997
Experimental & Molecular Medicine

Volume: 29, P: 177-182
Low-Voltage Electron Beam Irradiation of Normal and 5-Bromouridine Deoxyriboside-Treated L-P₅₉ Mouse Fibroblast Cells In Vitro

ARTHUR COLE
RONALD M. HUMPHREY
WILLIAM C. DEWEY
Research24 Aug 1963
Nature

Volume: 199, P: 780-782
‘Lampbrush’ Fibres in the Chromosomes of Chrotogonus incertus Bolivar

M. D. L. SRIVASTAVA
Research12 May 1951
Nature

Volume: 167, P: 775-776
Utilization of sequential model-based optimizer integrated machine learning models in correlation of famotidine solubility in supercritical carbon dioxide

Hadil Faris Alotaibi
Chou-Yi Hsu
Ashish Singh Chauhan
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Direct evidence of coupling between charge density wave and Kondo lattice in ferromagnet Fe₅GeTe₂

Kondo interaction can mediate intertwined charge and magnetic orders in 2D d-electron systems. Here, using scanning tunneling microscopy, the authors reveal that Fe(I) atoms mediate atomic scale √3x√3 spatial coherence among charge density wave, Kondo physics, and ferromagnetism in the 2D ferromagnet Fe₅GeTe₂.

Parry Pei-Rui Luo
Hung-Chang Hsu
Ya-Ping Chiu
ResearchOpen Access31 May 2025
Nature Communications

Volume: 16, P: 1-9
Structure and assembly of filamentous bacterial viruses

D. A. Marvin
E. J. Wachtel
Research03 Jan 1975
Nature

Volume: 253, P: 19-23
Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease

Metabolic and alcohol-related liver disease presents challenges in clinical trials due to complex pathophysiology. This Review discusses noninvasive imaging, serum biomarkers and adaptive designs as modalities to enhance patient-centric end points, aiming to refine diagnostics and improve drug development.

Luis Antonio Diaz
Maja Thiele
Rohit Loomba
Reviews26 Sept 2025
Nature Reviews Gastroenterology & Hepatology

P: 1-19
Production of Cold Agglutinins in Rabbits immunized with Human Erythrocytes treated with Mycoplasma pneumoniae

TEN FEIZI
D. TAYLOR-ROBINSON
R. A. CARTER
Research28 Jun 1969
Nature

Volume: 222, P: 1253-1256
Coexistence of charge and ferromagnetic order in fcc Fe

The coexistence of different magnetic and electronic phases often occurs in materials with complex chemical compositions, allowing for the study of competitive, collaborative, or emergent phenomena. Here, the authors demonstrate such behaviour in ultrathin Fe films on a Rh(001) substrate.

Pin-Jui Hsu
Jens Kügel
Matthias Bode
ResearchOpen Access14 Mar 2016
Nature Communications

Volume: 7, P: 1-6
A competitive disinhibitory network for robust optic flow processing in Drosophila

Navigation relies on detecting left versus right body asymmetries for gaze and course stability. A central three-layer optic flow-sensitive network with competitive lateral disinhibition extracts asymmetries from complex motion patterns.

Mert Erginkaya
Tomás Cruz
M. Eugenia Chiappe
ResearchOpen Access01 May 2025
Nature Neuroscience

Volume: 28, P: 1241-1255
High performance data integration for large-scale analyses of incomplete Omic profiles using Batch-Effect Reduction Trees (BERT)

This study presents BERT, an algorithm for high-performance integration of incomplete omics data with robustness to unequal phenotype distribution. It validates the method on simulated and experimental data from proteomics, metabolomics and transcriptomics.

Yannis Schumann
Simon Schlumbohm
Philipp Neumann
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Predicting the direction of phenotypic difference

Here authors reveal a method to predict key information on phenotypes - their direction. This is achievable even for phenotypes with incomplete genotype-to-phenotype mapping, and applicable for individuals from the same family or population, as well as between species.

David Gokhman
Keith D. Harris
Gili Greenbaum
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Dielectric Diffusion—A New Cross Phenomenon

M. M. BREUER
D. ROBINSON
Research22 Mar 1969
Nature

Volume: 221, P: 1116-1118
Experimental demonstration of logical magic state distillation

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

Pedro Sales Rodriguez
John M. Robinson
Sergio H. Cantú
Research14 Jul 2025
Nature

Volume: 645, P: 620-625
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Hind Rafei
Rafet Basar
Katayoun Rezvani
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 1076-1086
Cholinesterase-Containing Systems of the Brain of the Rat

C. C. D. SHUTE
P. R. LEWIS
Research21 Sept 1963
Nature

Volume: 199, P: 1160-1164
Curare Sensitivity in Neonatally Thymectomized Mice

MICHAEL E. BLAW
ROBERT A. GOOD
RAYMOND D. A. PETERSON
Research09 Apr 1966
Nature

Volume: 210, P: 129-130
Palladium nanoparticles immobilized in SnFe₂O₄/SiO₂/PM as efficient heterogeneous catalysts for the suzuki cross-coupling reaction

Anjan Kumar
Magda H. Abdellattif
Pushpa Negi Bhakuni
ResearchOpen Access31 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Mycobacterium phlei Fatty Acid Synthetase—A Bacterial Multienzyme Complex

D. N. BRINDLEY
S. MATSUMURA
K. BLOCH
Research15 Nov 1969
Nature

Volume: 224, P: 666-669
Time cell sequences during delay intervals are not dependent on brain state and do not support hippocampus-dependent working memory

Whether sequential or persistent hippocampal activity patterns support working memory is not fully understood. Here authors found that, irrespective of the firing patterns—sequential or persistent, neither of these subgroups of cells was found to store a memory. These findings suggest that hippocampal activity alone does not maintain working memory over longer periods.

Li Yuan
Jose F. Figueroa
Stefan Leutgeb
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Field Control of Plant Growth and Development through the Laser Activation of Phytochrome

L. G. PALEG
D. ASPINALL
Research05 Dec 1970
Nature

Volume: 228, P: 970-973
Efficient light upconversion via resonant exciton-exciton annihilation of dark excitons in few-layer transition metal dichalcogenides

The authors report upconversion in few-layer transition metal dichalcogenides, and attribute it to a resonant exciton-exciton annihilation involving a pair of dark excitons with opposite momenta, followed by the spontaneous emission of upconverted bright excitons.

Yi-Hsun Chen
Ping-Yuan Lo
Shao-Yu Chen
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-11
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors

Engineered, bifunctional receptors present antigens and initiate signaling in response to binding to the cognate T cell receptor. Libraries built with SABRs can screen thousands of epitopes for the discovery of T cell target antigens.

Alok V. Joglekar
Michael T. Leonard
David Baltimore
Research28 Jan 2019
Nature Methods

Volume: 16, P: 191-198
Dynamic observation of defect annealing in CdTe at lattice resolution

R. Sinclair
F. A. Ponce
C. J. D. Catto
Research08 Jul 1982
Nature

Volume: 298, P: 127-131
On the origin of the universal dielectric response in condensed matter

K. L. Ngai
A. K. Jonscher
C. T. White
Research18 Jan 1979
Nature

Volume: 277, P: 185-189
Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals

T. L. BLUNDELL
J. F. CUTFIELD
M. VIJAYAN
Research25 Jun 1971
Nature

Volume: 231, P: 506-511
Messenger and aminoacylation functions of brome mosaic virus RNA after chemical modification of 3′ terminus

D. S. SHIH
PAUL KAESBERG
T. C. HALL
Research24 May 1974
Nature

Volume: 249, P: 353-355
Impact mechanics of the Cretaceous–Tertiary extinction bolide

John D. O'Keefe
Thomas J. Ahrens
Research08 Jul 1982
Nature

Volume: 298, P: 123-127
Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious

D. Simon
H. Stuhlmann
R. Jaenisch
Research21 Jul 1983
Nature

Volume: 304, P: 275-277
Polyploidy in Animals

C. D. DARLINGTON
Research31 Jan 1953
Nature

Volume: 171, P: 191-194
Optically initialized robust valley-polarized holes in monolayer WSe₂

The long associated lifetimes required to exploit valley polarization in electronic devices, along with charge and spin, have yet to be observed. Here, the authors demonstrate the photoexcitation of long-lived valley-polarized holes in WSe₂.

Wei-Ting Hsu
Yen-Lun Chen
Wen-Hao Chang
ResearchOpen Access25 Nov 2015
Nature Communications

Volume: 6, P: 1-8

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