Search

An optical archival storage technology based on femtosecond laser direct writing in glass addresses the practical demands of archival storage.

The luminescent and magnetic properties of trivalent lanthanides are indispensable for many emerging technologies, but exacting fine control over these properties requires an understanding of the coordination geometry and site symmetry of Ln³⁺ centres. Here, the authors leverage an analysis of 12,670 eight-coordinate Ln³⁺ centres in the Cambridge Structural Database to prescribe useful strategies for controlling coordination geometry.

In one-shot perceptual learning, what we see can be dramatically altered by a single past experience. Using psychophysics, fMRI, iEEG, and DNNs, the authors identify neural and computational mechanisms underlying this remarkable ability in humans.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Forests are essential for both climate change mitigation and biodiversity conservation, yet how to balance these goals in managed forests remains unclear. Here, using a Europe-wide dataset, the authors find that biodiversity increases with carbon stocks, but mostly when deadwood is included.

Energy storage and biomass utilization are two major challenges for sustainability. Here the authors use a major lignin hydrogenolysis product for the synthesis of an N-heterocycle and develop a bimetallic catalyst for repeated hydrogenation/dehydrogenation of this and other molecules for hydrogen storage.

Hepatic glycogenolysis is essential for protein glycosylation and rhythmic secretion by the liver. Disruptions to hepatic glycogenolysis, caused by congenital diseases or physiological factors such as obesity, caloric restriction and changes to meal timing, alter hepatic protein secretion.

Thermal imaging lenses are typically made from expensive materials such as germanium and silicon. Here, the authors synthesise a sulfur-based polymer with high mid-wave infrared and long-wave infrared transparencies, presenting a high-performing, low-cost alternative to traditional thermal imaging lens materials.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

Dietary n-6 PUFAs enhance adipose tissue expandability through the PPARγ–LPCAT3 membrane remodelling axis.

Electrified thermal energy storage converts electricity into heat for thermal energy use. This Review assesses available and emerging technologies, identifying research needs for scalable, long-duration and efficient deployment.

Using two newly developed immunoassays tested in three clinical cohorts, this study highlights CSF DOPA decarboxylase as a promising biomarker for differentiating dementia with Lewy bodies and Parkinson’s disease from Alzheimer’s disease and controls.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

How climate change will impact microbial community growth is unclear. Here, the authors use a field experiment with varying global change factors, finding fungal growth more drought-resistant than microbial growth and overall changes in bacterial growth strategies.

Integrating complex multi-omics data for individual patient decision making can be challenging. Here, the authors develop Knowledge Connector as a decision support system to generate and document Molecular Tumor Board recommendations and support medical decision-making.

Metabolite signatures were identified for subtypes of dietary carbohydrate, including added sugar, whole grain and refined grain, and showed different associations with type 2 diabetes, providing an objective measure of dietary risk.

Termite reproductives are long-lived and their genomes have abundant selfish genetic elements. Using long-read sequencing to profile transposable elements and DNA methylation, Qiu et al. uncover evolutionary arms races between TEs and host defences.

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated in clinical samples. Concomitantly blocking TGFβ signaling with chemotherapy reduces tumor burden and increases survival in mice.

Rak et al. report the visualisation of internal domain boundaries in perovskite single crystals, revealing that electric fields produced by localised flexoelectricity separate electric charges, reducing recombination of charge carriers, and leading to long-lived photocurrent under zero bias.

Conserving mangrove biodiversity has numerous co-benefits, including climate change-mitigation. Here the authors demonstrate that blue carbon storage in mangroves can be best sustained by combining site-specific dominant species with other species with contrasting functional traits.

Adipogenin is a microprotein expressed in adipose tissue. Previous studies have suggested its role in lipid storage, yet the underlying molecular mechanisms have been unclear. A recent study published in Science presents evidence that adipogenin forms complexes with seipin, a protein that is essential for lipid droplet formation in adipocytes, thereby modulating lipid storage.

Theories of Cenozoic mountain uplift and associated global cooling assume that eroded mountain sediments are stored in marine basins. Here, based on detailed provenance data, Nie et al. show that Northeast Tibetan sediments are in fact stored inland, in the Chinese Loess Plateau and Mu Us desert.

This study quantifies Brazil’s soil carbon debt (1.40 Pg C) and demonstrates that improved agricultural practices enhance carbon recovery. The findings reveal Brazil’s significant capacity to mitigate emissions and influence global carbon markets.

Mountains are hotspots of climate change, with melting glaciers, changing water flows and moving ecosystems. Here the authors discuss how these different changes in mountain regions affect downstream regions.

Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.

This work focuses on clathrates, ice-like structures incorporating H₂ molecules in their cages. In bulk, pure H₂ clathrates only form in harsh conditions. Here, the formation of pure H₂ clathrate hydrate in confined space of a porous silica is demonstrated at much reduced pressures compared to the bulk H₂ clathrate.

Rechargeable aqueous electrochemical energy storage is a promising technology but suffers from a narrow potential window. Here the authors report a surface hydroxylated Mn₅O₈pseudocapacitor electrode with bivalence structure that expands the potential window to deliver high energy and power performance.

This multicenter study demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings.

Artificial intelligence is driving rapid growth in electricity demand, straining grid reliability and infrastructure. This study demonstrates a software-based method that allows data centres to adjust workloads in response to real-time grid signals, reducing power use and supporting grid stability without hardware modifications.

Electricity storage will benefit from both R&D and deployment policy. This study shows that a dedicated programme of R&D spending in emerging technologies should be developed in parallel to improve safety and reduce overall costs, and in order to maximize the general benefit for the system.

Taveneau et al. leverage artificial-intelligence-driven protein design to create inhibitors that control RNA-targeting enzymes in cells, revealing a strategy to rapidly design off-switches for RNA-editing systems.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Lipid nanoparticles (LNPs) are a versatile class of clinically approved drug delivery vehicles, particularly for nucleic acid cargoes, but they often suffer from instability issues. Here, the authors report that the room temperature stability of small interfering RNA LNPs formulated with unsaturated ionizable lipids can be improved by inclusion of mildly acidic, antioxidant-containing buffers.

Microbial carbon use efficiency is a strong predictor of soil organic carbon stocks. Here the authors reveal that the microbial growth rate is a more reliable and informative predictor, and that modelling approaches tend to overemphasize the role of biotic over abiotic controls compared to empirical data.

The Connectome Annotation Versioning Engine (CAVE) is a platform for proofreading, annotating and analyzing datasets reaching the petascale. Currently, CAVE is used for electron microscopy datasets, but it can potentially be used for other large-scale datasets.

Writing data in DNA is still a bottleneck due to the reliance on chemical synthesis methods. Here the authors report multiplexed enzymatic DNA synthesis using maskless photolithography.

Glacierized regions that are projected to become ice-free in this century could provide substantial water storage and hydroelectric power, according to this worldwide theoretical assessment.

A multi-variate GWAS of cerebellar morphology yielded 351 genetic loci (226 novel, 94% replicated). Follow-up analyses revealed links to recent human evolution and genetic overlap with major mental disorders.

This protocol describes the synthesis, purification and assembly of stable branched 4-way junction (4WJ) RNA nanoparticles conjugated with multiple hydrophobic chemotherapeutic drug molecules to target specific tumors with minimal side effects.

Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production but also promotes the recruitment of DGAT2 to droplet surfaces.

Redox-active non-conjugated radical polymers are promising candidates for metal-free aqueous batteries but their energy storage mechanism in an aqueous environment remains unclear. The role of the electrolyte in such polymers for designing metal-free aqueous energy storage electrodes is now elucidated.

Keeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.

The lysosomal storage disease mucopolysaccharidosis I is treated with recombinant α-L-iduronidase but production of the enzyme is expensive. In this study, α-L-iduronidase is compartmentalized within the endosperm of maize via a unique mRNA strategy yielding the active, correctly glycosylated protein.

The authors report that the interplay between structural water and highly disordered vanadium oxide can stabilize the layered metal oxides and enhanced their performance for aqueous potassium-ion storage based on neutron scattering measurements and electrochemical characterizations.

This work highlights how changes to beaches are related to sand movement and human impacts to the coast and illuminates opportunities for sand management to resolve shoreline erosion and enhance beach sustainability.