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Polarization measurements are reported for the blazar Mk501, revealing a degree of X-ray polarization that is more than twice the optical value and supporting the shock-accelerated energy-stratified electron population scenario.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Cuproptosis is an emerging mode of programmed cell death for tumor suppression but limited by the copper ion regulatory mechanisms in most tumor cells. Here, this group develops a Cu9S8-based nanoplatform for breast cancer-targeting and cuproptosis-induction via ATP7A interference, thereby eliciting thermodynamic cancer therapy.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

A growth process in which protons decouple graphene from the underlying substrate greatly reduces the number of wrinkles that usually degrade large graphene films grown by chemical vapour deposition.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

The topological properties of twisted bilayer MoTe₂ are thought to stem from a spatial texture in the layer polarization of the electronic wavefunctions. This polarization is now measured using scanning tunnelling microscopy.

In June 2022, the IXPE satellite observed a shock passing through the jet of active galaxy Markarian 421. The rotation of the X-ray-polarized radiation over a 5-day period revealed that the jet contains a helical magnetic field.

Tetrasubstituted alkenes are found in bioactive compounds and materials, but modular stereospecific synthesis of these compounds remains challenging due to reactivity and selectivity issues of the intermediate compounds. Here, the authors disclose a carboboration of alkynyl selenides, which provides an intermediate with two readily distinguishable sites of functionalization, providing rapid access to stereodefined tetrasubstituted alkenes.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

The practicality of osmotic energy for portable electronics has been challenging despite recent advancements. Researchers devise a method to store iontronic energy in a polymer film based on osmotic effects, achieving high energy and power density.

Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting.

Water scarcity is intensifying in China, India, and the USA, with growth in unsustainable water demand equaling or outpacing that of total water demand. These nations are increasingly relying on water in already stressed regions to meet their needs.

In this contribution, the electrocatalytic hydrogen oxidation activity and CO resistance capability of Pt clusters are enhanced through the combination of the electron delocalization effect, which allows W3O/WC to share electrons with Pt clusters, and the oxygen spillover effect.

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Observational evidence shows that the occurrence of ultra-short-period planets increases with age and their system architecture evolves on billion-year timescales, providing new constraints on the formation and evolution of these lava worlds.

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

The existence and properties of tetraquark states with two heavy quarks and two light antiquarks have been widely debated. Here, the authors use a unitarized model to study the properties of an exotic narrow state compatible with a doubly charmed tetraquark.

Our understanding of reaction dynamics has developed as more accurate measurements of product state-resolved angular distributions have become available. Now, fast forward-scattering oscillations in the product angular distribution of the benchmark chemical reaction H + HD → H₂ + D have been observed and are in excellent agreement with quantum-mechanical dynamics calculations.

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

The discovery of a distant blazar J0410−0139 at z = 7 suggests that many similar sources existed in the early Universe, supporting the hypothesis that the rapid growth of black holes is driven by jet-enhanced or obscured accretion.

The accurate determination of quark mixing parameters is essential for the understanding of the Standard Model. The LHCb collaboration now reports the coupling strength of the b quark to the u quark through the measurement of a baryonic decay mode.

Marginal liver grafts are associated with a higher risk of graft failure due to their increased susceptibility to ischemia-reperfusion injury. Here, the authors show the regulatory mechanism of fibroblast growth factor 21 and offer insights into its clinical application in early liver graft injury.

Avocado fatty alcohols/acetates (AFAs) are effective against parasitic nematodes, including drug resistant strains, and show safety in mammalian cells. AFAs target lipid metabolism, offering the potential for new anthelmintic treatment pathways.

6R-TaS2 is a natural van der Waals heterostructure formed by 1H- and 1T-phase TaS₂ layers, which can individually exhibit Ising superconductivity, correlated states and charge density waves. Here, the authors show experimental evidence of emergent nematic Ising superconductivity with simultaneous hidden magnetism (extrinsic anomalous Hall effect and Kondo screening) in 6R-TaS₂ under 30 K.

The mechanism of proanthocyanidin (PA) polymerization has been debated for decades. Here the authors propose a role for a miRNA and a Laccase in PA polymerization in Salvia miltiorrhiza.

CP violation has deep implications for particle physics and cosmology. Previously observed only in meson decays, signs of CP violation have now been spotted in baryon decays by analysing the proton–proton collision data from the LHCb detector.

Metalloligands provide a potent strategy for manipulating the surface metal arrangements of metal nanoclusters (NCs), but their synthesis and subsequent installation onto metal NCs remains a significant challenge. Here, the authors demonstrate the synthesis of two atomically precise silver NCs by controlling reaction temperature and demonstrate thermal induced structure transformation between the clusters during a temperature-dependent assembly process.

The second Global Amphibian Assessment finds that the status of amphibians is continuing to deteriorate globally, driven predominantly by climate change, disease and habitat loss.

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

The authors present an exciting 3D meta-holography based on angular spectrum diffraction theory that significantly improves depth limits. The showcased amorphous silicon metasurface with independent polarization control herein achieves a 47.5x depth increase and 0.95 dm depth reconstructions for polarization-independent and different color 3D meta-hologram.

Invariant natural killer T (iNKT) cells are important contributors to anti-tumour immunity, but they often become dysfunctional in cancers. Here authors show that inhibited iNKT intra-tumour motility and iNKT cell exclusion from tumours by macrophages both contribute to their diminished function in cancer, and by therapeutic interference with the respective motility and iNKT-macrophage interaction pathways, their function can be restored.

Underwater soft robots made of stimuli-responsive shape-changing hydrogels generally present low actuation speed which is limited by the water diffusion between hydrogels and their surrounding environment. Here, the authors develop dynamic hydrogel robots with a fast and switchable actuation based on a thermally driven chain conformation change after mechanical programming.

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

A four-dimensional printable shape memory hydrogel with shape-shifting onset adjustable by changing the programming conditions is reported.

The co-occurrence of chronic diseases in the same person increases the risk of negative health events. Here authors show that grouping people based on their underlying disease patterns helps to identify homogeneous groups of people with similar needs and prognosis, facilitating personalized approaches.

Radiative cooling is a sustainable subambient cooling technology. Here, authors show a scalable and practical design of a dual-selective thermal emitter that is shown to have enhanced radiative cooling potential over existing typical designs.

The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestistant breast cancer cells.