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Using the well-established foundry-based lithium niobate nanophotonics platform, a general electro-optic digital-to-analogue link with ultrahigh bandwidth (>150 Gb s⁻¹) and ultralow power consumption (0.058 pJ b⁻¹) is demonstrated, providing a direct, energy-efficient, high-speed and scalable solution for interfacing digital electronics and photonics.

150 years ago, guanidine was found to affect muscle function via unknown mechanisms. Here, Kavita et al. provide evidence that guanine-sensing RNAs are present in many eukaryotic transcripts relevant to Ca2+ signaling and neuromuscular function.

Accomplishing multiple synthetic tasks in parallel including substrate capture, separation, and reaction, all in one system, has remained a long-standing challenge in synthetic chemistry. Here, the authors report a sorting polymerization strategy that harnesses the multifunctional nature of a bichannel metal-organic framework.

Despite their differences, the rarer sarcoma CIC::DUX4 sarcoma (CDS) is typically treated with therapies developed for Ewing Sarcoma (EwS) with limited success. Here, the authors develop a co-clinical drug response profiling platform to establish patient-derived CDS and EwS tumoroids, identifying MCL1 inhibition as a promising therapeutic approach in CDS.

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Body size and composition are complex traits that are challenging to characterize due to environmental and genetic influences. Here, Arehart et al. disentangle shared and distinct genetic signals underlying body size and composition.

Identifying genes involved in MYC-driven lymphoma reveals therapeutic vulnerabilities. Here, the authors show by using CRISPR knockout screens in primary cells in vivo that the GATOR1 complex suppresses MYC-driven lymphomagenesis, and that GATOR1-deficient lymphomas are sensitive to mTOR inhibitors.

The authors demonstrate single-photon γ-ray imaging with pixelated CsPbBr3 semiconductor detector, providing enhanced energy resolution and improving performance uniformity by minimizing mechanically induced defects. This advances applications of perovskites in nuclear medicine.

The authors examine the impact of monthly unconditional cash transfers starting at childbirth on families with low incomes. Transfers had minimal effects on family processes and maternal wellbeing, but improved family incomes and time mothers spent doing enriching activities with their child.

A DNA-binding protein, DnaA, regulates the initiation of chromosomal replication in bacteria. Here, Olivi et al. show that the bacterial chromosome sequesters DnaA in a growth rate-dependent manner, suggesting a role for titration in the coordination of DNA replication.

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

R-loops formed by RNA hybridization to DNA template strand during transcription influence HIV-1 integration into the CD4⁺ T cell genome. The unwinding of R-loops by splicing helicase Aquarius facilitates integration into speckle-associated domains.

Uneven zinc growth limits the reversibility of zinc metal batteries. Here, authors use in situ X-ray computed tomography and fluid dynamics simulations to reveal how synthetic clay coating suppresses chaotic ion flow, enabling uniform zinc growth and stable cycling in a large-scale pouch cell.

Achieving mitigation from forests aligned with #NDCs requires $20–72 billion annually by 2030. Global coordination could double mitigation with the same level of finance, revealing major efficiency gains and informing next generation climate targets.

This work proposes a wet-chemical etching assisted aberration-enhanced single-pulsed femtosecond laser nanolithography, named “WEALTH”, for manufacturing small-size, large-area, deep holey nanostructures, promising for emerging nanophotonic devices.

The origin of timber was correctly identified for 94% of samples in Central Africa, a high-risk region with low tracing accuracy to date, according to an analysis that combined genetic, stable isotopes, and elemental concentrations methods.

Multivariate genome-wide association analyses of the latent genetic architecture of frailty identify one general factor of genetic overlap across all frailty deficits and six factors indexing a shared genetic signal across specific groups of deficits.

Much investment goes into improving police-community interactions, yet trust in police remains low. Here, the authors show that community members report feeling less threat and more trust when officers use transparency statements to start interactions.

A large brain imaging study of over 2000 people worldwide shows that fear conditioning engages brain regions linked to emotion and attention, with differences in individuals with anxiety or depression and strong influences from task design.

A strongly lensed galaxy at redshift z ≈ 6 is resolved into at least 15 star-forming clumps embedded in a rotating disk. Clump formation in this system, which is not predicted by cosmological zoom-in simulations, may be driven by disk instabilities with weak feedback, rather than past mergers.

Amyloid fibrils can adopt a range of distinct conformations, yet it is challenging to rapidly discriminate between these polymorphs. Now methods have been developed to screen large, diverse libraries of turn-on fluorescent dyes to rapidly identify probes that recognize fibril subsets.

Epidemic outbreaks can decimated populations, potentially driving natural selection on genetic variants that offer protection. This study presents SimOutbreakSelection (SOS), a simulation-based framework for designing well-powered studies to detect genetic variants that have been under epidemic-driven selection, showing that large sample sizes are needed even for severe epidemics.

Egan et al. examine multisensory evidence accumulation and show that auditory and visual evidence is accumulated in distinct processes during multisensory detection, and cumulative evidence in the two modalities sub-additively co-activates a single, thresholded motor process.

This multiomic study, including single-nucleus DNA methylation and chromatin conformation matched with single-nuclei RNA sequencing, provides insights into the epigenomic landscape of human subcutaneous adipose tissue.

Here, the authors show that giving probiotics to very low birth weight preterm babies can help reduce harmful antibiotic-resistant bacteria in the gut and support the development of a healthier microbiome.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Li et al. characterize overlapping and divergent metabolic requirements of human and murine NK cells in response to activation, with a focus on serine metabolism

The limited proliferative capacity of erythroid precursors complicates the production of red blood cells for clinical purposes in vitro. Here, the authors show that erythroid proliferative capacity can be vastly increased by BMI1 overexpression, which regulates erythroid self-renewal through both gene repression and activation.

N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network without inducing autoinflammatory responses.

Embedding complex networks in hyperbolic spaces facilitates navigation and link prediction, though recent techniques face diminishing improvements. The authors present CLOVE, a scalable method that hierarchically organizes communities down to the node level by solving instances of the Travelling Salesman Problems, delivering high-quality embeddings and high efficiency for networks up to millions of nodes.

Alloying layers boost the longevity of lithium metal batteries. Here, authors combine nuclear magnetic resonance and impedance spectroscopy to provide insights, revealing enhanced interfacial transport and diminished dead lithium formation as the origins of improved reversibility with Li-Sn alloys.

Patients with different small round cell sarcoma (SRCS) often receive the same treatment regimen but for some SRCS subtypes, response to chemotherapy is poor and targeted treatment options are limited. Here, the authors establish a biobank of paediatric patient-derived SRCS tumoroids and perform drug screening, identifying MCL inhibition as a potential therapeutic strategy in CIC::DUX4 sarcomas.

Phased Array Transducers (PATs) are used to shape ultrasound. They require complex electronics and are hard to scale, which limits their ability to form sophisticated patterns. Here, we introduce an analog platform that uses light to shift the electrical phase of the transducers and demonstrate versatile ultrasonic functions in a scalable device.

Samples returned from asteroid Bennu largely comprise hydrated sheet silicates with sulfides, magnetite and carbonate that indicate alteration by a fluid that evolved from neutral to alkaline, according to a micro- and nanoscale mineralogical study.

Solid waste can impact public health, climate change and ocean pollution, yet many countries lack basic infrastructure to manage it. A study now shows that investing in simple waste systems in lower-income countries delivers greater co-benefits than upgrading high-tech systems in wealthier ones.

By doping ice with NaCl, it is shown that a flexoelectric coefficient of up to 10 μC m⁻¹ is generated, enabling effective piezoelectric coefficients that are comparable to those of ceramics. This arises from the streaming current of quasi-liquid flow through grain boundaries from one side of the sample to the other.

Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfamilies, distributed across a wide range of bacteria, likely to adopt a similar architecture.

Current industrial methods of ethylene glycol production generate substantial CO₂ emissions. Here electrocatalytic ethylene-to-ethylene glycol conversion is coupled to electrochemical CO₂ capture, decreasing carbon intensity by an order of magnitude.