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The authors significantly enhance the high-temperature energy storage performance of bismuth sodium titanate-based relaxor ferroelectric multilayer ceramic capacitors via entropy modulated strain heterogeneity.

Acetyl-CoA synthetases have been proposed as targets for development of new antimicrobial drugs. Here, Jezewski et al. identify isoxazole-based compounds with activity against the pathogenic fungus Cryptococcus neoformans, and describe their mechanism of action as inhibitors of fungal acetyl-CoA synthetases.

Cannulae are heat-resistant protein nanotubes found on the surface of thermophilic archaea. Here, the authors report the structures of cannulae at the atomic level with insight into their high stability and mechanism of assembly, which has potential impact for biomaterials design.

Chromosomes are coated in proteins and RNA called the mitotic chromosome periphery. Here, broadband microrheology analysis has shown that this coat has dynamic, liquid-like properties and provides an external structural constraint.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Here the authors use Ramsey interferometry to study Tan’s contact in uniform two-dimensional Bose gas of 87Rb atoms across the Berezinskii–Kosterlitz–Thouless superfluid transition. They find that the two-body contact is continuous across the critical point.

Using chiroptical imaging, the optical activity of a metal-organic framework (MOF) was directly correlated with its enantiomorphous (mirror-image) crystal shapes, a milestone that was unachievable in Pasteur’s era.

In an integrated analysis of transcriptomic data from the SUBSPACE consortium and public datasets of patients with sepsis, acute respiratory distress syndrome, trauma and burns, dysregulation within four consensus molecular clusters related to myeloid and lymphoid cells is associated with mortality and illness severity.

A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

In this Review, the authors describe and discuss hypoxia-associated extracellular matrix mechanisms of neutrophil recruitment, polarization and immunosuppression, how these lead to immunotherapy resistance, and potential targets to overcome ICI resistance.

Perturbations to strongly lensed galaxy light in very long baseline interferometric imaging reveal a dark and unusually low-mass object at redshift z ≈ 0.9.

Systems with strong photon-photon interactions enable advanced quantum optical applications as well as the study of highly correlated light-matter states. Here the authors report strong coupling between single- and two-photon states in a superconducting circuit, enabling a new regime of nonlinear quantum optics.

The ρ-type GABAA receptors are potential therapeutic targets in several neurological conditions. Here, authors elucidate interactions of it with three therapeutic drugs, offering mechanistic insights and a prospective basis for further pharmaceutical development.

In this study, Yang et al. compile a global dataset to uncover the degree to which plants coordinate root and seed traits. They report a global positive correlation between root diameter and seed size, driven by dual roles of arbuscular mycorrhiza in phosphorus uptake and pathogen defence.

Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.

Drugs that rescue function of episodic ataxia 1 (EA1) mutant potassium channels are lacking. Here, Manville et al identify and describe the molecular basis for Native American botanical ataxia remedies that directly rescue EA1 mutant channels.

Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

Integrated scanning probe techniques in combination with first-principles theory unveil the crystallization of electron polarons into quasi-one-dimensional polaron superlattices in individual polypentacene molecules.

Indonesian cattle are unique due to their history of admixture involving both zebu and banteng. Here, Wang et al. identify ~3.5 million novel introgressed SNP variants and provide a genomic map of banteng introgression within and across many cattle breeds, each with unique introgression histories.

In advancing the design of electronic devices, the dielectric tunability of barium strontium titanate is enhanced by an order of magnitude relative to the previously reported values through the manipulation of polar domain characteristics.

Here, the authors investigate gene dosage compensation in mouse pluripotent stem cells to better understand the process of X-chromosome upregulation. They report that mammalian cells can sense when segments of one of the two X chromosomes are genetically deleted in cis and compensate gene expression by upregulation in trans.

Lung adenocarcinoma is often curable when diagnosed at an early stage, but a subsection of patients will progress. Here, the authors use multi-omics profiling to show that gene expression data can predict clinical outcome.

Broad-spectrum vaccines have been proposed as a tool for rapid response to emerging infectious disease threats and are in pre-clinical development. Here, the authors use mathematical modelling to assess the potential impacts of broadly protective sarbecovirus vaccines for a hypothetical “SARS-X” outbreak.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Nitrogen-rich Ruddlesden–Popper nitrides are notoriously difficult to stabilize. Now a high-pressure high-temperature synthesis method has enabled the preparation of Pr₂ReN₄, Nd₂ReN₄ and Ce₂TaN₄. Neutron diffraction analysis reveals fully nitrided materials and intricate magnetic structures.

We present a sustainably sourced adhesive system, with performance comparable to that of current industrial products, made from epoxidized soy oil, malic acid and tannic acid, all biomass derived, low cost and readily available.

Dimorphos ejecta plume properties were revealed by the observations from the LICIACube cube satellite, which was deployed 15  days in advance of the impact of DART.

Results from the randomized, noncomparative, phase 2 MATISSE trial show that ultra-short neoadjuvant therapy with ipilimumab and nivolumab can prevent surgery and radiotherapy in patients with resectable cutaneous squamous cell carcinoma, with an early decrease in total lesion glycolysis by [¹⁸F]FDG-PET/CT associated with response.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

 A bifunctional iminophosphorane-catalysed, stereo-controlled deconjugation for the synthesis of highly enantioenriched alkylidenecyclopropanes is described, alongside computational studies elucidating the mechanistic pathway and origins of diastereoselectivity and enantioselectivity.

A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells following treatment with hydroxychloroquine and/or everolimus.

Theoretical and experimental analysis of the effect of grain shape in bed load sediment transport is performed and a shape-corrected sediment transport law that provides greater accuracy in predictions is proposed.

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

Beading combines soft, compliant threads with discrete, rigid elements to make architected materials. Here, authors show how geometry, tension, and friction together enable programmable shape and tunable mechanical behavior.

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

LipCo biosynthesis in humans depends exclusively on a de novo pathway involving LIPT2, LIAS, and LIPT1. In this work authors present structures of LIAS captured in multiple catalytic states, revealing critical conformational changes associated with the reaction. The structures of the LIAS–H_pro complex define molecular interactions essential for complex formation. These structures enabled the mapping of amino acid changes associated with non-ketotic hyperglycemia.

During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce host and viral proteins that support virus spread.

The study reveals maps of the heliosphere’s termination shock strength. Asymmetries in the shock strength across the sky, from nose to tail and port to starboard flanks, are caused by the solar wind and interstellar medium dynamics.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

At elevated temperatures, electron hydrodynamics efficiently eliminate the ‘bulk Landauer–Sharvin’ resistance, demonstrating that hydrodynamics can dramatically modify the well-established rules obeyed by ballistic electrons.

A hybrid epoxy–acrylate resin is reported for the digital light processing 3D printing of bioinspired metamaterial structures with precisely patterned hard and soft domains.

The realization of the anomalous Hall effect in high-mobility two dimensional electron systems has so far remained elusive. Here, the authors observe its emergence in MgZnO/ZnO heterostructures and attribute it to skew scattering of electrons by localized paramagnetic centres.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.