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Showing 1–50 of 1845 results
Advanced filters: Author: James Hope Clear advanced filters

  • Liang et al. estimate the prevalence of text modified by large language models in recent scientific papers and preprints, finding widespread use (up to 17.5% of papers in computer science).

    • Weixin Liang
    • Yaohui Zhang
    • James Zou
    Research
    Nature Human Behaviour
    P: 1-11

  • Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key pitfalls around comparator arms and ancillary immune-modulating treatments.

    • Joan T. Merrill
    • Judith A. James
    News & Views
    Nature Medicine
    P: 1-2

  • The Global Flourishing Study provides a comprehensive view of the distribution and determinants of well-being by assessing domains such as health, happiness, meaning, character, relationships and financial security. Initial findings reveal significant variations in flourishing across countries and demographic groups, with factors such as age, marital status and religious service attendance showing strong associations with well-being.

    • Tyler J. VanderWeele
    • Byron R. Johnson
    • George Yancey
    ResearchOpen Access
    Nature Mental Health
    Volume: 3, P: 636-653

  • This Review summarizes recent technical advancements in generative AI, outlines how new models might improve healthcare and discusses validation approaches—using lessons from recent successes and failures in the field.

    • Zhen Ling Teo
    • Arun James Thirunavukarasu
    • Daniel Shu Wei Ting
    Reviews
    Nature Medicine
    P: 1-13

  • The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

    • Alexander S. Banks
    • David B. Allison
    • Juleen R. Zierath
    Reviews
    Nature Metabolism
    Volume: 7, P: 1765-1780

  • Dry age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. Evans and Syed discuss the pipeline of therapies for dry AMD and the future of the market.

    • James B. Evans
    • Basharut A. Syed
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 12, P: 501-502

  • Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

    • Sumeet A. Khetarpal
    • Haobo Li
    • Anthony Rosenzweig
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 1277-1294

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Hosseinzadeh et al. demonstrate use of a publicly accessible automated machine learning platform to differentiate between a common benign tumor and malignant transformation of it within the paranasal sinuses. This AI algorithm beat prior human prediction, and showed that physicians with no coding background can effectively utilize this tool.

    • Farideh Hosseinzadeh
    • George Liu
    • Zara M. Patel
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-7

  • Hematoxylin and eosin (H&E) staining is a widely used method in histopathology, but it cannot directly inform about specific molecular markers. Here, the authors present ROSIE, a deep-learning framework that computationally imputes the expression and localisation of dozens of proteins from H&E images.

    • Eric Wu
    • Matthew Bieniosek
    • James Zou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Gel electrophoresis image analysis still largely relies on manual or semi-automatic tools, limiting both efficiency and reproducibility. Here, authors introduce GelGenie, an AI-driven open-source platform that rapidly detects gel bands under various conditions.

    • Matthew Aquilina
    • Nathan J. W. Wu
    • Katherine E. Dunn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • There is no shortage of opinions on the impact of artificial intelligence and deep learning. We invited authors of Comment and Perspective articles that we published in roughly the first half of 2019 to look back at the year and give their thoughts on how the issue they wrote about developed.

    • Alexander S. Rich
    • Cynthia Rudin
    • Jack Stilgoe
    Special Features
    Nature Machine Intelligence
    Volume: 2, P: 2-9

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • In this instalment of Career pathways, James White and Wenjing Du reflect on the importance of recruiting the right people, staying excited and making work and home life coexist.

    • James P. White
    • Wenjing Du
    Reviews
    Nature Metabolism
    Volume: 3, P: 1277-1279

  • Political ecology aims to understand how politics and power influence both social and ecological dynamics. Conservation biologists and political ecologists tackle many of the same pressing environmental problems, but from quite different perspectives. In this Viewpoint, five political ecologists discuss their views on how the field can understand and tackle the biodiversity crisis.

    • Bram BĂ¼scher
    • Jessica Dempsey
    • Kate Massarella
    Reviews
    Nature Reviews Biodiversity
    Volume: 1, P: 622-626

  • How cells use biophysical processes to interpret complex input signals is not well understood. This study reveals limits to the computational power of generic non-equilibrium systems and shows how they can be overcome through features like enzymes acting on multiple targets.

    • Carlos Floyd
    • Aaron R. Dinner
    • Suriyanarayanan Vaikuntanathan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Testing two families of large language models (LLMs) (GPT and LLaMA2) on a battery of measurements spanning different theory of mind abilities, Strachan et al. find that the performance of LLMs can mirror that of humans on most of these tasks. The authors explored potential reasons for this.

    • James W. A. Strachan
    • Dalila Albergo
    • Cristina Becchio
    ResearchOpen Access
    Nature Human Behaviour
    Volume: 8, P: 1285-1295

  • For a third year in a row, we followed up with authors of several recent Comments and Perspectives in Nature Machine Intelligence about what happened after their article was published: how did the topic they wrote about develop, did they gain new insights, and what are their hopes and expectations for AI in 2022?

    • Cameron Buckner
    • Risto Miikkulainen
    • Vidushi Marda
    Special Features
    Nature Machine Intelligence
    Volume: 4, P: 5-10

  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136

  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128

  • Although Western mental health research has started incorporating lived experience expertise, this approach has not been widely adopted in most Asian countries. Embracing the unique perspectives of Asian people with lived experience can provide a more nuanced understanding of mental health and recovery.

    • Jonathan Han Loong Kuek
    Comments & Opinion
    Nature Reviews Psychology
    Volume: 4, P: 503-504