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In a SO(2) rotationally symmetric system, a general polarization-tuned mirror symmetry breaking mechanism was reported to highly efficiently generate a lateral optical force, enriching the optical manipulation mechanism for mirror-symmetric objects.

Genomic analyses of 2,191 global common wheat accessions and over 47,000 yellow rust (YR) response data points across several environments and pathogen races provide a genome-wide landscape of YR resistance genes and effective alleles.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

Evidence for the treatment of patients with mild-to-moderate COPD is limited. Here, the authors show that long-term treatment with high-dose N-acetylcysteine neither significantly reduced the annual rate of total exacerbations nor improve lung function in patients with mild-tomoderate COPD.

Minimizing the non-radiative energy loss without sacrificing the charge collection efficiency is the key to improve the performance of organic solar cells. Here, the authors develop hybrid side chain-based asymmetric small molecule acceptors and achieve maximum power conversion efficiency of 19.76%.

The monitoring of vital physiological parameters exemplified by intracranial pressure is of paramount importance. Here, the authors propose an ultrasensitive multimodal biotelemetric system to monitor ICP, respiratory, and heart rate.

The study identifies TaSPL6-D as a negative regulator of TaHKT1;5-D and salinity tolerance in bread wheat. An insertion variation of TaSPL6-D, mainly hidden in landraces, shows the potential for breeding salt-tolerant crops.

The majority of adoptive T cell therapy-based clinical studies are based on the ex vivo expansion of neoantigen-specific tumor infiltrating lymphocytes. Here the authors report the results of a pilot study of adoptive cell therapy with personalized neoantigen-specific CD8 + T cells obtained from peripheral blood mononuclear cells in patients with locally advanced or metastatic solid tumors refractory.

Organic solar cells processed from green solvents are easier to implement in manufacturing yet their efficiency is low. Chen et al. devise a guest molecule to improve the molecular packing, enabling devices with over 17% efficiency.

LRRC31 links DNA repair and radiation efficacy Chen et al. perform a genome-wide CRIPSR screen and identify LRRC31, which interacts with Ku70/80 to suppress DNA repair and enhances the efficacy of radiation therapy in breast cancer brain metastasis.

Second-generation oxidation boosts the production of anthropogenic organic aerosol, according to an analysis of urban haze in an experimental chamber.

A reconstruction of the light profile for the Milky Way from an internal perspective provides an estimate of the Galaxy’s size that can be directly compared to other galaxies. This property will help to understand how typical the Milky Way is.

Nutrient levels in Chinese lakes have rapidly increased since 1950 but future trends in lacustrine nitrogen and phosphorus across China will differentiate, according to projections up to 2100.

Historically, warm periods enhanced the Asian summer monsoon—increased rainfall brought additional nutrients to freshwater ecosystems and increased production. However, anthropogenic aerosols have weakened the monsoon and altered lake ecosystems.

The reliability of memristors has always been a major obstacle in neuromorphic computing. This work reports a negative differential resistance memristor based on quantum well structure for neuron circuit implementation, which shows low performance variation (0.264%), high temperature resistance at 400 °C.

Organic solar cells based on non-fullerene acceptors have enabled high efficiencies yet their charge dynamics and its impact on the photovoltaic parameters are not fully understood. Now, Chen et al. provide a general description of non-radiative voltage losses in both fullerene and non-fullerene solar cells.

Aggregation-induced emission (AIE) fluorescence probes are indispensable for biomedical imaging, however, interference with tissue autofluorescence results in low signal-to-noise ratio limiting the development of bioimaging with AIE materials. Here the authors develop AIEgen room-temperature phosphors with long emission lifetimes efficiently eliminating intereference with the background signal in imaging.

Improved treatment of glioblastoma (GBM) can be achieved by inducing differentiation of glioblastoma stem cells (GSCs). Here, the authors show that zinc finger protein 117 (ZNF117) is a regulator of GSC differentiation via Notch signaling through interaction with JAG2, and can be targeted for therapy.

An unusual violation of the Wiedemann-Franz law with enhanced Lorenz number is revealed by thermal Hall measurements in NdAlSi. As its origin, the authors propose the presence of a hidden Kondo-type scattering process between itinerant electrons and localized moments in this magnetic Weyl semimetal.

Cigarette smoking is an established risk factor for inflammatory bowel disease. The authors suggest that smoking may affect the risk of Crohn’s disease and ulcerative colitis by modulating the DNA methylation status of the DNMT3A, LTA/TNF, and AHRR region, respectively.

Here, employing proteomics profiling, the authors identify RPLP1 to be highly expressed in long-term non-progressors of HIV-1 infection. Functional validation shows that RPLP1 inhibits transcription of HIV-1 group M subtype B strains by blocking C/EBPβ binding sites, while RPLP1 knock-down promotes HIV-1 reactivation.

Key optoelectronic properties for donor and acceptor organic semiconductors are identified to obtain organic solar cells with reduced open-circuit voltage losses and high power conversion efficiencies.

RNA crosslinking and proximity ligation methods are used to identify transcriptome-wide base pairing interactions. Here, the authors report PARIS2 (psoralen analysis of RNA interactions and structures 2), a method for RNA duplex determination in vivo with higher efficiency than the previous PARIS method.

There is growing interest in designing photocatalysts for CO₂ conversion. Here, the authors combine an ionic liquid with Co single atoms as dual-cocatalysts for g-C₃N₄, accelerating electron kinetics and improving CO₂ reduction selectivity.

How the Asian monsoon, earth surface processes and human development interact is not well known. Here, a new record of dust storm intensity shows a relationship between the stability of dynasties and dust storm activity for the last ~2200 years, which argues for a strong human control of dust storms in East Asia over this time.

Development of lithium-sulfur cells is hindered by many problems such as the dissolution of polysulfides. Here, the authors use thin nickel-based hydroxide layers to entrap both sulfur and intermediate polysulfides in the cathode, which mitigates the problems leading to high battery performance.

Using donor-acceptor bulk heterojunction as sensitiser for efficient charge generation and low charge recombination in triplet-triplet annihilation upconversion, Bi et al report solid-state one-step printed device with upconversion efficiency of 2.2% and threshold excitation intensity of 10 mW cm⁻².

Due to the adjustable bandgap, flexibility, absence of heavy metals and high power per weight, organic laser converters have unique advantages in wireless power transfer. Here, authors integrate organic laser power converters exhibiting efficiency over 36% at 660 nm with photon flux of 9.5 mW/cm².

DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

In a cluster-randomized trial performed in 48 residential elderly care facilities in China, use of a low-sodium salt substitute instead of regular salt decreased blood pressure and cardiovascular events, whereas an alternative strategy of restricting salt consumption was not successful and did not have these beneficial effects.

Different two-dimensional materials can be grown epitaxially side by side to create one-layer-thick p–n junctions.

Kagome metals continue to attract interest due to the coexistence of electronic correlations and band topology. Here the authors use proton gating to modulate disorder and carrier density in CsV₃Sb₅ nanoflakes, and show its effect on superconductivity, charge density wave and anomalous Hall effect.

Adding electron-withdrawing groups to the backbone of the polymer PBDTTT is shown to increase the open-circuit voltage of photovoltaic cells, resulting in a polymer solar-cell that has a certified power-conversion efficiency of 6.77%.

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Liang et al. report mechanisms of migrasome biogenesis in migrating cells. They propose that sphingomyelin synthase 2 (SMS2) is required for migrasomes, first by localizing in stable puncta where they eventually form migrasome structures.

Despite the importance of grapevine cultivation in human history and the economic values of cultivar improvement, large-scale genomic variation data are lacking. Here the authors resequence 472 Vitis accessions and use the identified genetic variations for domestication history, demography, and GWAS analyses.

The dearth of glioblastoma model systems that accurately recapitulate the disease remains a challenge. Here, the authors develop cancer avatars using genetically engineered human induced pluripotent cells.

Samelson et al. report that BRD2 inhibition suppresses SARS-CoV-2 infection in epithelial cells and Syrian hamsters via reducing the transcription of host cell surface receptor ACE2.