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Showing 1–50 of 62 results

Advanced filters: Author: Jinghong Chen Clear advanced filters

The influence of meteorological factors on tuberculosis incidence in Southwest China from 2006 to 2015

Yuanyuan Xiao
Limei He
Zhen Yu
ResearchOpen Access03 Jul 2018
Scientific Reports

Volume: 8, P: 1-8
A structural information-guided cross-modal method for damaged inscription inpainting via vision-language models

Yunjing Liu
Erhu Zhang
Jinghong Duan
ResearchOpen Access02 Oct 2025
npj Heritage Science

Volume: 13, P: 1-20
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Preliminary results from a phase 2a trial involving 71 patients suggest that a new agent, discovered and designed with artificial intelligence assistance, is safe and effective for the treatment of idiopathic pulmonary fibrosis.

Zuojun Xu
Feng Ren
Alex Zhavoronkov
ResearchOpen Access03 Jun 2025
Nature Medicine

Volume: 31, P: 2602-2610
Conflict between conservation and development: cash forest encroachment in Asian elephant distributions

Peng Liu
Hui Wen
Li Zhang
ResearchOpen Access03 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

During periods of stress, it is required to maintain the haematopoietic stem cell (HSC) pool. Here the authors show that Trim47 is important in the survival and function of HSCs after exposure to stress, and prevents haematopoietic failure by inhibiting MAVS-mediated excessive activation of the innate immune pathway.

Fang Chen
Yukai Lu
Junping Wang
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection

By mimicking antigen processing and presentation during the rejection of xenotransplanted tissue, xenogeneic cell membrane-derived vesicles encapsulating peptide antigens or mRNA-encoded antigens function as vaccines targeted to dendritic cells.

Jinjin Wang
Yuxuan Zhang
Xing-Jie Liang
Research13 Feb 2025
Nature Biomedical Engineering

Volume: 9, P: 201-214
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation

X-ray crystallography, solution NMR and biochemical and cell-based analyses reveal a model where catalytically repressed receptor tyrosine kinases accomplish activation loop (A-loop) tyrosine transphosphorylation.

Lingfeng Chen
William M. Marsiglia
Moosa Mohammadi
Research20 Jan 2020
Nature Chemical Biology

Volume: 16, P: 267-277
Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage

How tissues adapt to extreme cold is not well understood. Here, the authors discover a mechanism that promotes FOXO1-mediated cold survival gene transcription at low temperatures, with potential implications for long-term tissue storage for transplantation.

Xiaomei Zhang
Lihao Ge
Jingxing Ou
ResearchOpen Access03 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Here, the authors show that GalNAc-T3 and T7 regulate furin cleavage of the SARS-CoV-2 spike protein via O-glycosylation. This influences viral assembly and infection, highlighting glycosylation as a host defense mechanism.

Shengjun Wang
Wei Ran
Yang Mao
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-17
A wearable echomyography system based on a single transducer

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

Xiaoxiang Gao
Xiangjun Chen
Sheng Xu
Research31 Oct 2024
Nature Electronics

Volume: 7, P: 1035-1046
Altered microbiota of the lower respiratory tract and its association with COVID-19 severity analysed by metagenomics and metatranscriptomics

Mechanistic modeling of enhancer-RNA sheds light on the role of transcription factors and their interactions in the context of estrogen-induced transcriptional program in breast cancer.

Denian Wang
Yishang Duan
Weimin Li
ResearchOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1-12
New loci and coding variants confer risk for age-related macular degeneration in East Asians

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
ResearchOpen Access28 Jan 2015
Nature Communications

Volume: 6, P: 1-10
Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors

Cpf1 has been repurposed as a transcriptional repressor in bacteria and plants. Here, the authors construct activators and repressors in human cells using Cpf1 coupled to riboswitches and GPCRs.

Yuchen Liu
Jinghong Han
Guohui Nie
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-8
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.

Zhenhua Liu
Nannan Yang
Beisha Tang
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-16
Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

Atomically dispersed gold supported by carbon dots amplifies mitochondrial oxidative stress, and leads to irreversible cell damage, inhibiting hepatocellular carcinoma in animal models.

Ningqiang Gong
Xiaowei Ma
Xing-Jie Liang
Research18 Feb 2019
Nature Nanotechnology

Volume: 14, P: 379-387
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
Amendments and Corrections30 Mar 2015
Nature Communications

Volume: 6, P: 1
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Measurement of the quantum capacitance of graphene

Electrochemical measurements show that the quantum capacitance of graphene is influenced by scattering from charged impurities, and also suggest that a longstanding puzzle about the interfacial capacitance in carbon-based electrodes has a quantum origin.

Jilin Xia
Fang Chen
Nongjian Tao
Research05 Jul 2009
Nature Nanotechnology

Volume: 4, P: 505-509
Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)

The xrRNA1 RNA from ZIKA virus (ZIKV) forms a complex ring-like architecture and is known for its mechanical anisotropy, but the mechanism for its direction-dependent mechanical responses remain unclear. Here authors use a single-molecule nanopore sensing technique combined with molecular dynamics simulations and show that the anisotropy in ZIKV xrRNA1 depends on Mg²⁺ and the key tertiary interactions.

Xiaolin Niu
Qiuhan Liu
Xianyang Fang
ResearchOpen Access30 Oct 2020
Nature Communications

Volume: 11, P: 1-14
Proton-driven transformable nanovaccine for cancer immunotherapy

A shape-changing pH-responsive cancer vaccine delivers antigenic peptides directly to the cytoplasm and boosts the cellular immune response upon activation of the inflammasome pathway, efficiently inhibiting tumour growth and extending survival in animal tumour models.

Ningqiang Gong
Yuxuan Zhang
Xing-Jie Liang
Research26 Oct 2020
Nature Nanotechnology

Volume: 15, P: 1053-1064
Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway

Xuan Chen
Jingying Huang
Jinghong Rao
Research13 Jan 2021
Hypertension Research

Volume: 44, P: 642-650
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation

Yingnan Bai
Liming Chen
Junbo Ge
ResearchOpen Access18 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma

Tingting Qian
Longzhen Cui
Chaozeng Si
Research06 Jan 2020
The Pharmacogenomics Journal

Volume: 20, P: 563-573
Arabidopsis seed germination speed is controlled by SNL histone deacetylase-binding factor-mediated regulation of AUX1

Histone acetylation influences the speed of seed germination. Here, Wang et al. show that loss of the SNL1/SNL2 histone deacetylase binding factors accelerates seed germination and provide evidence that they act by regulating the expression of AUX1which in turn influences cell division.

Zhi Wang
Fengying Chen
Yongxiu Liu
ResearchOpen Access11 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Prognostic role of SCAMP family in acute myeloid leukemia

Tingting Qian
Zhiheng Cheng
Lin Fu
Research28 Jan 2020
The Pharmacogenomics Journal

Volume: 20, P: 595-600
Ultrasonographic measurement of the optic nerve sheath diameter in dysthyroid optic neuropathy

Xian Ji
Wei Xiao
Huasheng Yang
Research30 Apr 2020
Eye

Volume: 35, P: 568-574
Molecular Characterization and Viral Origin of the 2015 Dengue Outbreak in Xishuangbanna, Yunnan, China

Yujiao Zhao
Lihua Li
Qiangming Sun
ResearchOpen Access29 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Amendments and Corrections27 May 2015
Nature Genetics

Volume: 47, P: 689
Single-cell transcriptomics across 2,534 microbial species reveals functional heterogeneity in the rumen microbiome

A single-cell transcriptomic resource of 174,531 microbial cells across 2,534 species allows the detection of single-cell-level functional roles in the rumen microbiome.

Minghui Jia
Senlin Zhu
Hui-Zeng Sun
Research12 Jun 2024
Nature Microbiology

Volume: 9, P: 1884-1898
CLDN18.2-targeting STAR-T cell therapy for pancreatic cancer: a strategy to minimize gastric off-tumor toxicity compared to CLDN18.2 CAR-T

Wei Zhang
Miao Zeng
Li Yu
Research29 Apr 2025
Oncogene

Volume: 44, P: 2440-2452
Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

Peichuan Xu
Jinghong Yuan
Xigao Cheng
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI

Linlin Gao
Rahul Gaurav
Tao Wu
ResearchOpen Access09 May 2024
Scientific Reports

Volume: 14, P: 1-10
Long non-coding RNA AC133552.2: biomarker and therapeutic target in osteosarcoma via PANoptosis gene screening

Wenrui Zhao
Yameng Wang
Jingyu Jia
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice

Ding Yan
XinTian Wu
Jinbao Liu
ResearchOpen Access19 Jul 2024
Cell Death Discovery

Volume: 10, P: 1-12
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung, Chiea-Chuen Khor and colleagues report the results of a genome-wide association study of exfoliation syndrome. They replicate a known association at LOXL1 and identify a previously unreported association at CACNA1A.

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Research23 Feb 2015
Nature Genetics

Volume: 47, P: 387-392
Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

Wenxin Luo
Jiadi Gan
Lei Chen
ResearchOpen Access14 Feb 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a

Daohong Zhao
Hong Chen
Yuhao Zhang
ResearchOpen Access18 Feb 2023
Scientific Reports

Volume: 13, P: 1-12
Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mechanisms

Wenna Nie
Yana Lv
Haitao Lv
ResearchOpen Access01 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Hongxu Pan
Zhenhua Liu
Beisha Tang
ResearchOpen Access09 Feb 2023
npj Parkinson's Disease

Volume: 9, P: 1-11
KLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis

Hui Wang
Hongyang Xu
Jinghong Dai
ResearchOpen Access04 May 2022
Cell Death & Disease

Volume: 13, P: 1-10
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment

Weinian Liao
Chaonan Liu
Junping Wang
Research30 Aug 2023
Cellular & Molecular Immunology

Volume: 20, P: 1216-1231
High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s disease

Chaodong Wang
Hankui Liu
Piu Chan
ResearchOpen Access23 Jul 2024
npj Parkinson's Disease

Volume: 10, P: 1-14
Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma

Lizhen Liu
Peng Deng
Jing Tan
ResearchOpen Access10 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-12
The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis

Yana Lv
Yan Mou
Guang Li
ResearchOpen Access07 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
Characteristics of germline DNA damage response gene mutations in ovarian cancer in Southwest China

Kaiyu Fu
Qingli Li
Rutie Yin
ResearchOpen Access20 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations

Yangyang Feng
Ming Zhao
Chu-Xia Deng
ResearchOpen Access11 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-13
Pentoxifylline and prevention of hyperoxia-induced lung injury in neonatal rats

Beatriz Almario
Shu Wu
Ilene R.S. Sosenko
Research09 Feb 2012
Pediatric Research

Volume: 71, P: 583-589
Computational frameworks transform antagonism to synergy in optimizing combination therapies

Jinghong Chen
Anqi Lin
Peng Luo
ReviewsOpen Access19 Jan 2025
npj Digital Medicine

Volume: 8, P: 1-22
HMGCS2 and AMACR as potential targets linking mitochondrial dysfunction and ulcerative colitis

Rui Zhu
Xinyu Bai
Junkun Niu
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-15
Prognostic value of the FUT family in acute myeloid leukemia

Yifeng Dai
Zhiheng Cheng
Lin Fu
Research17 Jun 2019
Cancer Gene Therapy

Volume: 27, P: 70-80

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