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A hybrid cathode interfacial layer (AZnO-F3N) is developed, delivering 21.0% efficiency along with excellent stability, mechanical robustness and broad versatility, highlighting its potential to advance organic solar cells.

A ligand oxidation structure-adaptive strategy creates an ultra-thin passivation nanolayer that enables copper and its alloys to resist corrosion and oxidation in harsh environments while retaining intrinsic electrical and thermal conductivities.

Xiao, Dong, Xie, Feng et al. developed FRα-targeting chimeras (FRTACs) for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies of targeted proteins. The folate polyvalency of FRTACs enables high affinity and potency of FRTACs in eliminating target proteins.

Global consumption drives freshwater overuse at production sites along supply chains, of which 24% is outsourced via trade. Agricultural demand is a key driver, while manufacturing exports exacerbate water stress in emerging economies.

Candida auris is a fungal pathogen notorious for persistent skin colonization and transmission in healthcare settings. Here, Zhao et al. explore the mechanisms driving pathogen’s adherence to skin, involving a conserved adhesin, as well as the potential of collagen coatings as a strategy to reduce C. auris adherence to abiotic surfaces.

Developing porous hemostatic sponges remains challenging. Here, authors proposed a temperature-assisted secondary network compaction strategy following the phase separation induced primary compaction to fabricate the superporous chitosan sponges.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Sodium-ion batteries face challenges due to electrode degradation and interphase instability. Here, authors develop a smart gel polymer electrolyte for hard carbon||NaNi_1/3Fe_1/3Mn_1/3O₂ batteries via in situ polymerization of specific monomers in conventional electrolytes.

Traditional silicon vision chips often challenge in emulating complex biological behaviors. This work reports birdlike broadband neuromorphic visual sensor arrays with 5 bits of in-memory sensing and computing. The built reservoir computing system achieves motion and UV grayscale information extraction, leading to fusion visual imaging.

The current use of elastography ultrasound faces challenges, including vulnerability to subjective manipulation, echo signal attenuation, unknown risks of elastic pressure and high imaging hardware cost. Here, the author shows a virtual elastography to empower low-end ultrasound devices with state-of-art elastography function.

Acute-on-chronic liver failure (ACLF) is characterized by rapid deterioration of liver function in patients with chronic liver disease. Here, the authors show that BTLA expression in CD4⁺ T cells is associated with disease severity and inflammation in hepatitis B virus-related ACLF.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

The identification of post-translational modifications (N-glycosylation and phosphorylation) in GPR52, an orphan G-protein-coupled receptor, shapes the intrinsic signaling bias and can modulate GPR52-dependent accumulation of the huntingtin protein in brain cells.

Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signalling molecules in metabolic processes. Here, the author show 13-HODE produced by senescent hepatocytes and macrophages activates SREBP1 by directly inhibiting CAT activity and promotes age-related steatosis.

The power conversion efficiency of wide-bandgap pure-sulfide kesterite is low. Wang et al. propose annealing in a hydrogen-containing atmosphere and report the underlying mechanism that enables a certified efficiency of 11.4%.

A-to-I editing in animals is catalyzed by enzymes of the Adenosine Deaminase Acting on RNA family, orthologues of which do not exist in fungi. Here, Feng et al. characterise the enzymes involved in A-to-I mRNA editing in Fusarium graminearum.

An on-chip microcomb that provides reference clocks for all synthesized signals and electronics within the system can be used to unite time–frequency references in optoelectronics.

Hepatic expression of constitutively active glucagon receptor may have contributed to the glucose and lipid metabolism and the high metabolic rates that enabled the evolution of flight in birds.

Multi-resonance materials possess narrow emission spectra, desirable for high-definition organic light-emitting diodes, but most are based on a boron-nitrogen skeleton, providing limited opportunities to expand the scope of these materials. Here, the authors report carbonyl-nitrogen skeleton 5,12-dihydroquinolino[2,3-b]acridine-7,14-dione and develop three multi-resonance materials with efficient green emissions and high photoluminescence quantum yields, and further demonstrate their promise through the fabrication of efficient hyperfluorescence OLEDs.

Electrochemical research often requires stringent combinations of experimental parameters that are demanding to manually locate. Here the authors report an autonomous electrochemical platform that implements an adaptive, closed-loop workflow for mechanistic investigation of molecular electrochemistry.

In China, about 10 percent of industrial sectors are the least efficient water users across 343 prefectures, and water savings opportunities exist in agriculture, the clothing and chemical industry, according to an analysis that uses water withdrawal data.

Soil conceals a vast realm of unexplored microbes, often referred to as the “microbial dark matter.” This hidden universe boasts a rich tapestry of microbial and genetic biodiversity. Here, the authors introduce the SMAG catalogue, comprising of 40,039 metagenome-assembled genomes from 3304 soil metagenomes, and uncovering 21,077 species-level genome bins.

PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.

Somatic cloning of rhesus monkey has not been successful until now. Here, authors report epigenetic abnormalities in SCNT embryos and placentas and develop a trophoblast replacement method that enables them to successful clone of a healthy male rhesus monkey.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Guan et al. analyse the impacts of COVID-19 restrictions on global supply chains. Earlier, stricter and shorter lockdowns can minimize overall losses. A ‘go-slow’ approach to lifting restrictions may reduce overall damages if it avoids the need for further lockdowns.