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Electrochemical CO_x reduction to multi-carbon products is hindered by low energy efficiency, in part due to sluggish ion transport across charge-selective membranes used in electrolysers. Here the authors use a porous, non-charge-selective separator that enhances ion transport and improves performance for CO electrolysis.

The accrual of soil carbon from absorptive fine roots exceeds that of leaf litter in forests despite lower productivity, according to an analysis of field observations from Northern Hemisphere forest sites.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Ligand-targeted nanocarriers are desirable for their potential to enhance precise drug delivery to targeted tissues, but their clinical translation faces challenges like protein corona formation. Here, Li et al. develop surface-galloylated liposomes that enable stable, non-covalent adsorption of antibodies while overcoming protein corona interference.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

The O-alkylation of tertiary alcohols with racemic tertiary electrophiles to access chiral hindered dialkyl ethers has remained elusive. Now this synthetic challenge has been accomplished by copper-catalysed C–O cross-coupling between tertiary haloamides and alcohols using designed ligands.

MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.

Fatigue-resistant functional bioadhesion is desired in diverse applications ranging from wound management to wearable devices but remains elusive. Here, the authors report the design, deployment, and mechanism of nanowhisker glues for fatigue-resistant functional bioadhesion.

Using an accurate genomic biomarker signature as a means to identify hypervirulent Klebsiella pneumoniae (hvKp-p), authors perform a longitudinal cohort study to provide insight into the clinical and genomic characteristics of hvKp-p.

A pore-modulated pyrolysis reactor that enables catalyst-free and energy-efficient upcycling of plastic waste is demonstrated. The graded-pore structure imposes molecular-weight-dependent transport barriers, establishing a gating effect that enhances product selectivity and yields aviation fuel precursor (C₈–C₁₈) with high efficiency.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Despite the ease of fine-tuning their reactivity, high-performance homogeneous photocatalysts competent for acetylene semihydrogenation are scarce. Here the authors introduce an effective cobalt catalyst for the production of polymer-grade ethylene, which is amenable to scale-up in a continuous-flow photoreactor.

The recent experimental creation of magnetic skyrmions, topologically protected particle-like spin textures, has inspired proposals for their application in nanodevices. Here, the authors use Lorentz transmission electron microscopy to demonstrate edge-mediated skyrmion chain formation in FeGe nanostripes.

Enzymes required for the production of hydrogen sulphide (H₂S) are expressed in mammalian reproductive tracts. Here, the authors show that production of H₂S regulates contraction in excised human fallopian tube samples and is required for transport of the embryo through the fallopian tube in mice.

Room temperature phosphorescent (RTP) materials are promising for optical applications. Here, the authors demonstrate a scalable preparation of RTP nanospheres and their assembly into photonic crystals with multimodal luminescence.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated domain, representing an uncommon architecture for paired NLRs in plants.

The neuroimmune interactions driving secondary degeneration in the injured spinal cord remain elusive. Here, the authors reveal that damaged microglia release IL-1α, resulting in neutrophil infiltration and the loss of mature oligodendrocytes through astrocytic and endothelial IL-1R1 in mice.

In this work, authors show that deletion of FprB enhances the antibacterial activity of gallium against Pseudomonas aeruginosa, revealing a combination strategy and demonstrating the utility of CRISPRi-seq for therapeutic target discovery.

The authors make multi-oriented nanodomain in BiFeO3-based ceramics via the strategic design of a dipolar region with high resilience to electric fields, achieving high energy storage density of 12.2 J cm−3 and energy storage efficiency of 90.1%.

Here, the authors identify integrin beta 4 (ITGB4) as a key entry factor for Zika virus infection. An antibody targeting ITGB4 protects against viral infection and prevents fetal damage in mice, offering a potential therapeutic strategy.

Two mGlu3–βarr1 cryo-EM structures with 2:1 and 2:2 stoichiometries are reported, revealing that the inactive state involves mGlu3 engagement of βarr1 through phosphorylated C-terminal tail and intracellular loops.

A recent synthesis study found 54% of the high-latitude peatlands have been drying and 32% have been wetting over the past centuries, illustrating their complex ecohydrological dynamics and highly uncertain responses to a warming climate.

The performance of wide bandgap perovskite solar cells is limited by the carrier recombination at their electron extraction interface. Here, the authors assemble binary 2D perovskites for efficient charge transport and realizing stable perovskite/silicon tandems with device efficiency over 30%.

The molecular mechanisms underlying the late-onset adverse effects of radiotherapy remain to be explored. Here, the authors observe compromised wound healing capacity in irradiated skin from breast cancer survivors and highlight THBS1 as a key epigenetically primed wound repair-related gene.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

Whether the circadian clock regulates early developmental processes is poorly understood. Here, the authors report the circadian rhythm of synapse formation during early brain development by using the retinotectal system of larval zebrafish as an in vivo model.

The authors report upconversion in few-layer transition metal dichalcogenides, and attribute it to a resonant exciton-exciton annihilation involving a pair of dark excitons with opposite momenta, followed by the spontaneous emission of upconverted bright excitons.

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

The authors report the cryo-EM structure of JA transporter ABCG16 in multiple conformations. It features a bifurcated translocation pathway, revealing the specific JA binding and transport mechanism that diversifies ABC transporters in higher plants.

Here, Ning et al report the cellular interactomes of Crimean-Congo haemorrhagic fever virus glycoproteins and uncover a host restriction factor HAX1 that hijacks the viral glycoproteins to mitochondria, disabling progeny virion packaging.

The performance of n-i-p perovskite-organic tandem solar cells is hampered by non-ideal interconnection layers. This study reports an optimized metal-based interconnection stack featuring high transparency and efficient carrier recombination, achieving 25.34% efficiency and improved stability in tandems.

Cervical cancer remains a significant public health problem in many regions. Here, the authors perform a proteogenomic analysis of cervical cancer in Chinese patients; they reveal proteomic subgroups associated with clinical and biological features, and a potential biomarker of response to radiotherapy.