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In drug discovery, the preparation of analogues with diverse core structures often requires laborious efforts. Now it has been shown that 1,2-oxaborines, which are synthesized from readily available starting materials, can serve as a versatile platform to allow rapid access to diverse central skeletons, thus simplifying the core diversification process.

An Ohmic contact interface engineering strategy was proposed by loading copper nano islands on indium hydroxide nanocubes, which could trigger and stabilize the polarized Cu0 -Cuδ+ active sites. Such catalyst enabled effective ammonia electrosynthesis with nitrate under ambient conditions

Myasthenia gravis (MG) is an autoimmune condition leading to extreme muscle weakness due to autoantibodies targeting the neuromuscular junctions. Here authors assign a critical role for platelets in amplifying the pro-inflammatory response in AChR+ immunotherapy-naïve MG (nMG) patients and thus contributing to disease pathology.

Simultaneous profiling of spatial transcriptomics (ST) and metabolomics (SM) offers a novel way to decode tissue microenvironment heterogeneity. Here, the authors present SpatialMETA, a conditional variational autoencoder-based framework designed for the integration of ST and SM data.

Integrating CO₂ capture and electrochemical conversion avoids the thermal release of CO₂ and thus could potentially lower the energy needed to make useful products from CO₂, but choosing optimal system components is still challenging. Here the authors use piperazine alongside a nickel catalyst for capture and achieve high energy efficiency and stable CO production.

Hydrogels have potential in the development of moist-electric generators, but pore structure and stability can limit performance. Here, the authors use delignified pomelo peel to confine a hydrogel to prepare moist-electric generator with sub-Debye length nanopores and desirable output voltage.

In this study meta-selective single-step bromination and chlorination reactions of pyridines and their derivatives are developed, with pyridinium radical cations as the key intermediates. A spin-density-controlled radical coupling process is proposed to be responsible for the reactivity and selectivity. The reaction features broad functional group tolerance with applicability in late-stage diversifications.

The need to use blue or high-energy near-UV light limit the synthetic applications of the combination of photocatalysis and transition-metal catalysis. Here, the authors report a method for red-light-driven nickel catalyzed cross-coupling reactions of aryl halides with 11 different types of nucleophiles using a polymeric carbon nitride as photocatalyst.

This work demonstrates an efficient electrochemical exfoliation approach to achieve high recovery rate for few-layered halogenated MXenes by leveraging gaseous propylene molecules as ‘physical scissors’, to enable advanced tribovoltaic nanogenerators.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Optimizing mechanical performance for polymer materials is frequently challenging, often require complex methods. Here the authors design an poly(ethylene glycol) material with enhanced mechanical properties by laser printing a micropillar and honeycomb micro-lattice.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Printable mesoscopic perovskite solar cells are a promising device design, yet their efficiency is limited by charge collection. Ma et al. use hexamethylene diisocyanate to eliminate unreacted organic cations at grain boundaries, enhancing hole collection.

C(sp³)–H fluoroalkylation of bioactive molecules is a challenge. Now, a scalable and site-selective allylic fluoroalkylation of terpenes and olefins has been developed using a cobaloxime catalyst. Mechanistic studies reveal the process probably proceeds through halogen-atom transfer and hydrogen-atom transfer steps.

Fuel cell catalysts meet increasing durability demands for heavy-duty applications. This study reveals that sub-angstrom strain in high-entropy intermetallics enhances both catalytic activity and long-term stability for the oxygen reduction reaction

A microphase crosslinking strategy, leveraging aziridine-based crosslinkers, is used to render organic thermoelectric materials stretchable and elastic.

Real-time neurotransmitter monitoring is crucial for neuroscience and brain disorder treatments. Here, the authors introduce a carbon coating method that achieves reliable, scalable neurotransmitter sensing, integrated with neural electrodes.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

Particle bombardment is a widely used tool for plant genetic engineering, but its low efficiency has been a bottleneck since its commercialization. Here, the authors design a flow guiding barrel to modulate particle and gas flow dynamics inside the gene gun and show its ability to enhance plant transformation efficiency.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Photocorrosion caused by unreacted holes limits the performance of photocatalysts for photocatalytic seawater splitting. Here, the authors report that a hollow ZnIn₂S₄ structure with CoOx and Pt single atoms enables efficient, durable hydrogen production from seawater via dynamic self-reconstruction.

Using data from six population-scale cohorts involving more than 10 million individuals, a large language model-based aging signature is shown to outperform traditional aging biomarker indices and signatures in predicting multiple health outcomes, at general and organ-specific levels.

Epstein–Barr virus - host chromatin interactions in nasopharyngeal carcinoma remain poorly understood. Here, the authors characterise the virus‒host chromatin interactions leading to genome reorganisation and identify a KDM5B-relevant signature associated with distant metastasis.

The authors study the layered superconductor AuSn₄ (T_c = 2.4 K) and reveal a two-fold symmetric angular dependence, consistent with unconventional pairing. They argue that the two-fold symmetry results from the Rashba-driven mixture of p-wave surface and s-wave bulk contributions.

Membranes which extract lithium are critical to developing sustainable technologies. Here, the authors report a covalent organic framework featuring randomly oriented channels, separating lithium from a mixture of cations.

Thermochromic smart windows often face trade-offs among luminous transmittance, solar modulation, and transition temperature, limiting their effectiveness in building energy savings. Here, the authors describe a hydrated ionic polymer window that reversibly transitions between transparent and blue states via temperature-induced hydration and dehydration, achieving high transmittance, strong solar modulation, and tunable transition temperature.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Hepatic fibrosis causes blood ammonia accumulation, which leads to hepatic encephalopathy. Here, a biocompatible water-powered Zn micromotor is developed for chemotactic migration towards and targeted clearance of ammonia for the treatment of hepatic encephalopathy.

Electrochemical reduction of carbon dioxide to more useful products is an industrially important process. Here, the authors report a nanoporous silver catalyst that efficiently and selectively reduces carbon dioxide due to its high surface area and intrinsically high activity.

Developing soft conductive gels for epidermal electronics is a challenge: Here, the authors introduced a liquid-to-solid transformation concept to improve biointerface integration.

Transition-metal-catalyzed couplings of propargylic alcohol derivatives with organometallic reagents proceeds via two-electron transformations, which present limitations in scope and selectivity. Here, the authors present visible-light-mediated copper-catalyzed cyanation of propargylic oxalates to form allenenitriles via a one-electron pathway

On-target, off-tumour toxicity is a major concern in immunotherapy. Here, aided by computer docking analysis, the authors introduce a single oxygen atom into the TLR7/8 agonist R848, generating a radiotherapy-activatable prodrug agonist that in mice helps mitigate systemic toxicity while triggering effective anti-tumor immunity responses upon radiation.

Allylic amination of unactivated alkenes with aliphatic amines is a long-standing synthetic challenge in organic chemistry. This is now accomplished in an oxidant-free, site-selective process by using a combination of a photocatalyst and cobalt complex for the coupling of olefins and alkyl amines with hydrogen evolution.

Gastric Squamous Cell Carcinoma (GSCC) is a rare subtype of gastric cancer with unknown etiology. Here, the authors identify frequent mutations in epigenetic regulation genes including EZH2 in twenty GSCC patient samples, and demonstrate that EZH2 loss, along with TP53 and PTEN loss, leads to GSCC in mouse models.

Single-atom catalysts commonly present a random distribution of the active metal centres. Now a series of Mg-rich intermetallic compounds is introduced to enable ordered dispersed active metals. Furthermore, a cascade process is demonstrated on Mg₂₉Pd_1.3Rh_2.7, where Pd sites catalyse the semihydrogenation of phenylacetylene with subsequent hydroformylation on Rh sites.

While many catalytic modes of palladium have been able to be supplanted by nickel catalysis, which is more Earth-abundant, enantioselective nickel-catalysed C–H activation remains unexplored. Here, the authors report an enantioselective C–H activation of metallocenes via a nickel–1′-bi-2-naphthol catalytic system.

Ketone α-alkylation at the more hindered site is challenging. Here, the authors report a highly regioselective nickel-catalysed allylic alkylation of unsymmetrical ketones at the more-hindered α-site with allylic alcohols.

Two-photon upconversion of 2D exciton was enhanced by 2440-fold in doubly-resonant nanocavity due to combined field localization and Purcell effect.

Twisted trilayer graphene is predicted to exhibit flat bands for an infinite set of twist angle pairs between the subsequent layers. Here, the authors study several samples with different twist angles and evidence robust flat bands in each of them.

Achieving high enantioselective control in the hydrogenation of aliphatic ketones is a long-standing challenge. Now, the design of a spiro iridium catalyst with a narrow, crowded chiral pocket allows highly enantioselective hydrogenation of these compounds.

A reverse osmosis membrane synthesized via a vapour–solid interfacial reaction demonstrates high permselectivity and exhibits good anti-fouling performance, providing a simple and effective methylation approach to enhancing membrane-fouling resistance.

Detailed mapping of the distribution of water and semiheavy water in the coma of Halley-type comet 12P implies a D/H ratio that is consistent with that of Earth’s water, indicating a common heritage.

High throughput virtual screening of robust blue thermally activated delayed fluorescent emitters has yet been implemented. Here, authors reveal a linear relationship of the difference between bond dissociate energy and first triplet state energy with the logarithm of device operational lifetime.

The germline is established during embryogenesis when primordial germ cells are first specified. Here they show that the RNA-binding proteins DND1 and NANOS3 function together to repress the translation of SOX4, restricting the germ cell lineage specification during embryonic development.

In divergent carbonylative transformations using identical starting substrates, ligand-assisted transition metal catalysis has dominated selectively controllable transformations, but achieving precise control of CO insertion in transition-metal-free systems remains a challenge. Here, the authors disclose a divergent radical tandem carbonylation of multisubstituted homoallylic alcohols for the synthesis of γ-lactones and 1,4-diones.

Understanding interfacial proton transport in an excited state is crucial for catalytic and diagnostic applications of nanomaterials. Here, the authors combine ultra-low-field NMR relaxometry with a light source to study the light-induced proton dissociation of graphene quantum dots.