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A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

The synthesis of carbon dots with efficient solid-state emission is difficult, requiring harsh conditions. Here, the authors develop a mild molten-salt synthesis route and use machine learning to optimize the luminous efficiency of carbon dots.

In situ observations reveal explosive mass ejections due to magnetic reconnection in the ionosphere of Mars, with a density cavity as direct evidence. Reconnection between strong open crustal fields can rapidly eject a large amount of mass from Mars.

The quality of the Li–electrolyte interface is key to solid-state battery performance, especially at low pressure. Here, authors use operando electron microscopy to reveal how Li-Mg alloy anodes improve interfacial contact and low-pressure cycling stability by suppressing void formation.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.

Dendritic cell-based therapies have been exploited as immunotherapeutic approaches for cancer treatment. Here the authors report a platform integrating antigen-capturing nanoparticles and type 1 conventional dendritic cells for in situ cancer immunization, promoting anti-tumor immunity in preclinical models.

Wu and colleagues identify gene networks and transcription factors that control the differentiation of stem-like CD8+ CAR T cells into effector or exhausted CD8⁺ CAR T cells.

Multi-omics data are readily integrated using quartet reference materials.

Low-dielectric-constant (k < 2) materials are needed to reduce crosstalk, delay and power consumption in microelectronic circuits. Here, the authors report the growth of low-k 2D fluoride-rich polymer thin films, showing good mechanical properties and their application for the realization of 2D MoS₂ transistors with improved performance.

The understanding of polyamorphic transitions is of scientific and technological importance. Here, the authors report a continuous polyamorphic transition without first-order transition characteristics in high-entropy metallic glasses.

Calcium is essential mineral nutrient for human but how it accumulates in rice grains is largely unknown. This study identifies a chloroplast vesicle localized protein GCSC1 that regulates calcium allocation to grains via flag leaf transpiration control.

Xue-Qing Yu, Jian-Jun Liu and colleagues report results of a genome-wide association study of IgA nephropathy in Han Chinese. They identify two new susceptibility loci at 8p23 and 17p13 and replicate previously reported signals in the MHC region and at 22q12.

Metallic transition metal dichalcogenides are important materials for catalysis, but scalable and controllable preparation methods are scarce. Here, the authors synthesize 2H-TaS₂ as centimetre-scale films of tunable thickness and show they are an efficient catalyst for hydrogen evolution.

Biocompatible afterglow materials have potential in imaging applications, but are challenging to prepare. Here the authors report the development of carbon nanodots with near-infrared afterglow, and demonstrate their use in imaging for tumour resection.

Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here the authors create bio-computers using engineered E. coli colonies that respond to chemical gradients, producing different logic functions depending on how they are spatially arranged.

Inherited congenital heart defects are prevalent in the human population, but the molecular mechanisms are poorly understood. In this article, deficiency in the chromatin remodelling factor, Brg1, is shown to alter cardiac development in both mouse and zebrafish laboratory models.

The development of flexible thermoelectrics is limited by the low power factor and brittleness of materials. Here the authors present strategy to turn Bi₂Te₃-based single crystals into flexible films with staggered-layer structure while maintaining superior thermoelectric performance.

Single sodium-ion solid electrolyte that meets the requirements of practical applications is difficult to design. Here, the authors show how kinetic stability via the creation of a self-passivating solid electrolyte interphase allows a homogenous glass solid electrolyte to exhibit remarkable electrochemical stability with sodium metal.

Serotonin, a well-known neurotransmitter in animals, is also produced by plants. In rice, biosynthesis of serotonin through the cytochrome P450 CYP71A1 gene increases the susceptibility of plants by promoting growth of destructive insects.

Genetic circuits can be built with bifunctional dynamic regulation of gene expression. Here the authors design a thermosensitive switch for spatial and temporal control of colony pattern, cell shape and polymer production.

During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological data, provide a comprehensive view of RdRP translocation.

Genome-wide association analysis of an improved telomere length score, calculated from quantitative PCR and whole-genome sequencing measurements in 462,666 individuals in the UK Biobank, identifies novel genes and variants underlying this trait.

The assembly of eight high-quality rapeseed genomes allows identification of presence and absence variations (PAVs) and small variations. PAV-based genome-wide association analysis uncovered causal variations for agronomic traits and ecotype differentiation.

Glass-to-glass transitions can help understanding the glass nature, but it remains difficult to tune metallic glasses into significantly different glass states. Here the authors demonstrate the high-entropy effects in glass-to-glass transitions of high-entropy metallic glasses.