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Showing 1–50 of 599 results
Advanced filters: Author: Ryan Yang Clear advanced filters
  • Electronic, health-care and energy applications largely rely on miniaturized structures, the fabrication of which, although technically beneficial, is energy intensive and requires the use of hazardous chemicals. Now, research shows an effective bioinspired strategy to reduce such environmental impacts while retaining the benefits of microfabrication.

    • Jing Meng
    • Feng Ryan Wang
    News & Views
    Nature Sustainability
    Volume: 7, P: 1088-1089
  • Programming stimulus responsiveness into living systems enables advanced biocomputation. Here, the authors autonomously compile proteins with defined topology that can be site-specifically tethered to and conditionally released from biomaterials and cells following user-specified Boolean logic.

    • Ryan Gharios
    • Murial L. Ross
    • Cole A. DeForest
    Research
    Nature Chemical Biology
    P: 1-11
  • Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

    • Boya Guo
    • Yanwei Cai
    • Burcu F. Darst
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experiments across multiple continents suggest that these learned calls provoke an innate response even among allopatric species.

    • William E. Feeney
    • James A. Kennerley
    • Damián E. Blasi
    Research
    Nature Ecology & Evolution
    P: 1-13
  • The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

    • Jiekun Yang
    • Cassia Wang
    • Manolis Kellis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

    • Douglas M. Russell
    • Felix Kunkler
    • Joachim Curtius
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

    • Jan-Torge Schindler
    • Joseph F. Hennawi
    • Riccardo Nanni
    ResearchOpen Access
    Nature Astronomy
    P: 1-13
  • New field measurements and modeling show meltwater refreezing in Greenland’s bare ice may reduce runoff to surrounding oceans, highlighting a process climate models can incorporate for improved predictions of future sea-level rise.

    • Matthew G. Cooper
    • Laurence C. Smith
    • Dirk van As
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

    • Maximilian Zenk
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

    • B. Kool
    • K. Verhaegh
    • V. Zamkovska
    ResearchOpen Access
    Nature Energy
    Volume: 10, P: 1116-1131
  • Observations of SN 2021yfj reveal that its progenitor is a massive star stripped down to its O/Si/S core, which remarkably continued to expel vast quantities of silicon-, sulfur-, and argon-rich material before the explosion, informing us that current theories for how stars evolve are too narrow.

    • Steve Schulze
    • Avishay Gal-Yam
    • Shrinivas R. Kulkarni
    Research
    Nature
    Volume: 644, P: 634-639
  • Deep learning-based generative tools are used to design protein building blocks with well-defined directional bonding interactions, allowing the generation of a variety of scalable protein assemblies from a small set of reusable subunits.

    • Shunzhi Wang
    • Andrew Favor
    • David Baker
    ResearchOpen Access
    Nature Materials
    Volume: 24, P: 1644-1652
  • Microbes that colonise ice sheet surfaces are important to the carbon cycle, but their biomass and transport remains unquantified. Here, the authors reveal substantial microbial carbon fluxes across Greenland’s ice surface, in quantities that may sustain subglacial heterotrophs and fuel methanogenesis.

    • T. D. L. Irvine-Fynn
    • A. Edwards
    • A. Hubbard
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • The rapid dissociation of methanetetrol has been suggested as an impediment to its observation, despite the stability of its substituted derivative orthocarbonates. The authors identify methanetetrol as a product of carbon dioxide and water reactions in space-simulation experiments via photoionization mass spectrometry working in tandem with computation quantum chemistry.

    • Joshua H. Marks
    • Xilin Bai
    • Ralf I. Kaiser
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Integration of snATAC-seq and snRNA-seq data from brains of individuals with major depressive disorder identifies chromatin accessibility alterations and functional enrichment of risk variants in deep-layer excitatory neurons. Gray matter microglia in these individuals show decreased accessibility at sites bound by regulators of immune homeostasis.

    • Anjali Chawla
    • Doruk Cakmakci
    • Gustavo Turecki
    Research
    Nature Genetics
    Volume: 57, P: 1890-1904
  • Transcription factors (TFs) represent an emerging class of therapeutic targets in oncology. Here, the authors develop Epiregulon, a computational method that constructs gene regulatory networks from ChIP-seq, ATAC-seq and RNA-seq data for accurate prediction of TF activity at the single-cell level, thereby facilitating the discovery of therapeutics targeting TFs.

    • Tomasz Włodarczyk
    • Aaron Lun
    • Xiaosai Yao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Here the authors identify the granin hormone SCG2 as a ligand for the inhibitory receptor LILRB4. They show that SCG2 released from tumors can suppress antitumor immune responses via this interaction, indicating possible therapeutic strategies.

    • Xing Yang
    • Ryan Huang
    • Cheng Cheng Zhang
    Research
    Nature Immunology
    Volume: 26, P: 1567-1580
  • A simple and versatile strategy is established to facilitate molecular recognition by extending electron catalysis for use in supramolecular non-covalent chemistry.

    • Yang Jiao
    • Yunyan Qiu
    • J. Fraser Stoddart
    Research
    Nature
    Volume: 603, P: 265-270
  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103
  • A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.

    • Timothy F. Huddy
    • Yang Hsia
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 627, P: 898-904
  • Next-generation batteries will present different risks to conventional lithium-ion cells, emphasizing the need for efforts towards characterizing the abuse tolerance and hazards associated with next-generation battery materials over their life cycle and providing the data in the context of supporting affected professionals.

    • Chuanbo Yang
    • Avtar Singh
    • Donal P. Finegan
    Reviews
    Nature
    Volume: 645, P: 603-613
  • Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

    • Noam D. Beckmann
    • Phillip H. Comella
    • Alexander W. Charney
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

    • Jingxuan Bao
    • Junhao Wen
    • Li Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Alkynes found in natural products are typically assembled by metal-dependent enzymes. The enzyme BesB instead forms a terminal alkyne-containing amino acid using pyridoxal phosphate as a cofactor. Here, the authors use structural and mechanistic investigations to identify the key features of BesB that allow it to carry out its fascinating chemistry.

    • Jason B. Hedges
    • Jorge A. Marchand
    • Katherine S. Ryan
    Research
    Nature Chemical Biology
    P: 1-10
  • The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

    • Hind Rafei
    • Rafet Basar
    • Katayoun Rezvani
    ResearchOpen Access
    Nature
    Volume: 643, P: 1076-1086
  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712
  • Integrated single mode lasers capable of extremely narrow linewidths and high output power will enable precision portable quantum, microwave, and sensing applications. Here we demonstrate a simultaneous record low fundamental linewidth and high output power using an integrated Brillouin laser in a meter-scale silicon nitride coil resonator.

    • Kaikai Liu
    • Karl D. Nelson
    • Daniel J. Blumenthal
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • To find materials with large anomalous Nernst coefficients, which is useful for energy harvesting, it is common to focus on materials with large anomalous Hall coefficients. Here, Gong et al. find a material where the anomalous Nernst effect does not show the same antisymmetric behaviour as the anomalous Hall effect.

    • Dongliang Gong
    • Junyi Yang
    • Jian Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7
  • FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

    • Sven Dorkenwald
    • Arie Matsliah
    • Meet Zandawala
    ResearchOpen Access
    Nature
    Volume: 634, P: 124-138
  • Wind turbine retirement will result in large end-of-life material flows that must be managed. This Review discusses material reuse and recycling options for composites, steel, rare-earth elements and concrete.

    • Fanran Meng
    • Jennifer L. Hawkin
    • Lixiao Zhang
    Reviews
    Nature Reviews Clean Technology
    Volume: 1, P: 677-698