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The authors achieve a high electrocaloric effect in barium titanate ceramics with a defect dipole engineering strategy. As a result, defect dipole engineering enables BaTiO₃ to achieve an electrocaloric effect over a wide temperature range.

Efficient voltage-controlled regulation of water and ion transport was achieved in stable Zr₄-Ti₃C₂T_x membranes. Under negative voltage, water diffusion was enhanced while ion transport was suppressed. This provides a promising strategy to overcome the intrinsic permeability– selectivity trade-off.

Efficient and accurate constant potential simulation is essential for electrochemical modeling. Here, authors propose a constant potential framework by combining the machine learning force field with the charge equilibration method to study the dendrites nucleation at the Li metal battery interface.

High-mass-loading electrodes are essential for high-energy all-solid-state batteries but suffer from poor kinetics. Here, authors use neutron imaging to identify ion-transport limitations and introduce a gradient solid electrolyte design that improves battery mass-loading and rate performance.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Cathode materials for lithium-ion batteries typically possess octahedral coordination, which may exclude other possible solutions to degradation during deep cycling. A series of tetrahedral-framework-based amorphous Li–V–O–F materials are investigated, and shown to demonstrate O–O formal redox at 4.1 V.

A nanoengineered, zero-volume-change, complete-sealing Li-based composite electrode, comprising multilayer reduced graphene oxide and zinc oxide, is developed, achieving Li plating/stripping Coulombic efficiencies of ≥99.99%.

Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO₂ as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO₂ dissolved in seawater that is subsequently converted to succinate in a bioreactor.

Adherent-invasive strains of E. coli are commonly isolated from patients with Crohn’s disease. Here, the authors show that an AIEC harbours a hybrid Type IV secretion system (T4SS) that mediates pilin polymerization and biofilm formation in vivo.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Nickel-heavy battery chemistries raise concerns over cost, supply risk and environmental impact. A new design cuts nickel use by over one-third, replacing it with more abundant manganese—without sacrificing performance.

Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role in determining the distribution of tau pathology.

Using an electrolyte micro-emulsion strategy, a lithium anode and high-voltage cathode can be simultaneously stabilized by liquid–liquid interfacial tension to achieve high-energy-density lithium-metal batteries.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

High plating currents are achieved in solid-state batteries without dendrites by densifying Li₆PS₅Cl, with modelling showing how specific microstructural changes increase the critical current density.

High-resolution ALMA observations reveal a gravitationally bound septuple protostar system in NGC 6334IN, formed through disk fragmentation. This discovery sheds light on the formation of extreme high-order multiplicity in massive stellar clusters.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

A scalable strategy to assemble anisotropic GO and MXene membranes with pH-tuned edge functionalization enables programmable bending via thermo-responsive water release, with applications in soft robotics and adaptive bionic architecture

Infant KMT2A-rearranged acute lymphoblastic leukemia is associated with poor overall survival rates. Here, the authors use WGS and WES of 36 relapsed KMT2A-rearranged ALL and AML patients and find alterations in drug response genes in ALL, which may correspond with relapse time. Longitudinal analyses of >250 samples could track residual leukemia cells, clonal drug responses, and the upcoming relapse.

Bacterial deaminase toxins are weapons used in interbacterial antagonism and valuable tools in genome engineering. Here, the authors show how a single-stranded DNA-specific deaminase toxin, SsdA, deaminates cytosines in a sequence context-independent fashion and its utility in base editing.

BioID detection of Ebola virus–host interactions when computationally integrated with existing host protein-protein networks, revealed functional cell protein complexes supporting infection, including the RNA decapping complex.

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Contributions of vehicular and structural proton transport are quantified in phosphoric acid electrolytes, with linking structural diffusion to hydrogen bonds. The derived conductivity model guides electrolyte-conductivity trends and identifies 5.8 M for low-temperature batteries.

DNA damage from chemotherapy can activate cGAS–STING and interferon pathways. Here, the authors show that cGAS–STING signaling is specific to DNA rich in CA repeats, whereas DNA not rich in CA repeats is detected by AIM2, resulting in opposing tumor immune responses.

Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.

Advances have been made in thin-film piezoelectrics; however, the linearity of electric-field-induced strain with frequency and temperature still requires improvement. Here, by growing interlocked monoclinic and tetragonal polar nanoregions in (K,Na)NbO₃ thin films, highly linear strains of up to 1.1% are reported at frequencies up to 10⁵ Hz.

A single umbilical cord blood unit of CD34⁺ HSPCs produces a high number of CD19 CAR-iNK cells using a modified cell culture method.

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Monolayer amorphous carbon (a-C) has attracted attention due to its structural and electronic properties, but its synthesis has so far required the use of metal substrates. Here, the authors report the Te-assisted growth of large-scale 2D a-C patterns on various insulating substrates, confirming their insulating properties in quantum tunnelling devices.

The authors develop a molecular dopant to avoid the dimerization of the electron-selective material phenyl-C₆₁-butyric acid methyl ester, resulting in enhanced stability and efficiency in inverted perovskite solar cells.

Singla et al. report the secondary analysis of the Scaling Up Maternal Mental healthcare by Increasing access to Treatment (SUMMIT) trial.

Genomic deletions in poxviruses are not well understood, the authors found large deletions in >2% of Mpox virus genomes during routine surveillance, highlighting their role in poxvirus evolution and potential impact on diagnostics and therapeutics.

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Organic electrode materials offer a versatile and sustainable route for lithium-ion batteries, but their application is hindered by low working voltages and poor cycling stability. Now, it has been shown that dissolving halide electrolytes into organic electrodes effectively tunes the working voltage and enhances the electrochemical performance of all-solid-state batteries.

Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

This prespecified updated survival and exploratory subgroup efficacy analysis of the phase 3 DESTINY-Breast04 trial shows that trastuzumab deruxtecan treatment in patients with HER2-low metastatic breast cancer leads to continuous survival benefit irrespective of estrogen receptor or hormone receptor status.

The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

This work presents SCIGEN, a machine learning framework integrating geometric constraints into material generation. The framework enables the discovery of stable quantum material candidates, and the authors synthesize two predicted magnetic materials.

This study presents evidence for the existence of Neoarchean plate boundaries and triple junctions, supporting a mobile-lid tectonics model of the southern Superior Craton.