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Electronics and magnetic phase transitions typically do not involve mechanical degrees of freedom directly, but their impact on thermodynamic properties affects the mechanical response of a material. Here the authors show that resonators made from 2D materials exhibit anomalies at phase transitions.

The targeted development of proteome-wide selective covalent probes remains a challenge. Here, the authors show the exploration of the natural product Sulphostin as a starting point for dipeptidyl peptidase 8 and 9 inhibitor development.

By simulating the implementation of airport-based wastewater surveillance sites at the global level, a modeling study shows how this early warning system would perform in identifying sources of pandemic outbreaks, in time and space, and what the optimal location of monitoring sites would be.

Utilizing supercritical geothermal water could multiply energy production, but the abundance, location and size of such resources is unclear. Here, the authors present numerical simulations and suggest that supercritical water may play a key role in removing heat from all magmatic intrusions.

Coal is widely used for energy generation, but has not been considered for possible functional materials. Here, the authors report the one-step formation of graphene quantum dots from coal at yields of up to 20%, which is advantageous when compared with their syntheses from sp²-type carbon structures.

Energy decay, describing the leakage of system energy into the surrounding environment, has been used to characterize the energy interactions for individual resonators. Here, authors utilize energy decay to analyze and observe coherent energy transfer and beating phenomena in coupled micromechanical resonators.

Anti-NMDA receptor encephalitis is a severe brain disorder caused by autoantibodies that trigger NMDA receptor loss. Here, the authors show that ART5803, a monovalent antibody, blocks this process and restores function in cell and primate models.

Transcranial ultrasound stimulation (TUS) is a non-invasive method to modulate deep brain activity. Using direct recordings from implanted electrodes, we showed that TUS engages the human globus pallidus internus, with effects on neural oscillations and behavior.

[¹⁸F]OXD-2314 is a brain penetrant positron emission tomography radiotracer with high affinity for tau aggregates in Alzheimer’s disease (AD) and non-AD tauopathies based on in vitro and in vivo studies, and is suitable for first-in-human use.

Monkeypox virus genomic data from Nigeria and Cameroon, sampled between 2018 and 2023, indicate that the virus spread through repeated zoonoses in Cameroon, whereas in Nigeria, it spread mainly through human–human transmission, predominantly originating in Rivers State.

Perturbed B cell responses have been associated with Crohn’s disease. Here, the authors sequence the B cell receptor repertoire in patients with Crohn’s disease and identify shared B cell clones, thus implicating the presence of common Crohn’s disease-associated antigens driving a pathogenic B cell response.

A textile fibre computer combining sensing, memory, processing and communication in a 5-g mass has been developed, enabling distributed computation on the human body through garments.

Here the authors demonstate that counter to expectation provided by the relevant standard reduction potentials, a chloroberyllate, [{SiNDipp}BeClLi]2, reacts with the group 1 elements (M = Na, K, Rb, Cs) to provide the respective heavier alkali metal analogues, [{SiNDipp}BeClM]2.

Soil acidity constrains agricultural productivity in a large proportion of sub-Saharan Africa’s croplands. This study estimates the location- and crop-specific amounts of lime required to remediate acid soils, taking into account the profitability and returns on investment of liming in the year of application and beyond.

Emerging applications of steam electrolysis and electrochemical synthesis for future hydrogen technologies at intermediate temperatures set stringent requirements on the stability of protonic ceramic cells. Now a sintering approach enables densified Ce-free protonic zirconate cells with enhanced Faradaic efficiency and exceptional stability under harsh operating conditions.

A barcoded CRISPR base editing system isolates target clones from complex mammalian, yeast and bacterial populations.

A semiconductor chip, coupled to an ion-sensitive field effect transistor (ISFET) pH sensor, can amplify and quantitate DNA in real time without dyes, cameras and external heating devices.

Nanotubes exhibit high vibrational coupling to the environment but lack a theoretical description. Vacuum-isolated, suspended double walled nanotubes provide a damping model for mass coupling, offering new nanomechanics and nanofluidics insights.

The origin of life would have required enzymatic cooperation that was not susceptible to cheating replicators. The authors show theoretically that this does not require a cell membrane and instead can arise when enzymatic cooperation and physical association coevolve.

Micrometre-thick oriented 2D covalent organic framework (COF) films are prepared via kinetically trapped 3D covalent adaptable network (CAN) intermediates. Imine-linked CANs are formed through solution casting and align spontaneously during solvent evaporation. Upon solvothermal treatment, the amorphous CANs are converted into porous crystalline COF films without losing their molecular alignment.

Here the authors show that loss of TANGO2, a gene linked to an autosomal recessive disorder characterised by developmental delay, rhabdomyolysis, cardiac arrhythmias and metabolic disturbances, disrupts mitochondrial and cytoskeletal structure by impairing its interaction with CRYAB, leading to desmin aggregation and desminopathy, causing cardiomyopathy, muscle weakness, and metabolic dysfunction in mice and human cells.

Xu et al. find that large language models not only align with human representations in non-sensorimotor domains but also diverge in sensorimotor ones, with additional visual training associated with enhanced alignment.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

A bio-inspired supramolecular material combines tiny amino acid sequences present in proteins with equally small segments of the plastic poly(vinylidene fluoride), yielding high-performance sustainable ferroelectric nanostructures with potential for future resorbable bioelectronics, ultra-low power devices, and large-scale information storage.

Polymerization methods that control the cis/trans stereochemistry of repeating alkenes in polyalkenamers remain scarce. Now, an acyclic diene metathesis process has been developed that enables control over the stereochemistry of the polymer backbone. The method harnesses the reactivity of dithiolate Ru carbenes, in combination with cis,cis-diene monomers, to access several classes of polymers with tailored properties.

Surface dynamics play a central role in the biological function of natural supramolecular structures. Here, the authors investigate the nanoscale dynamics at the surface of synthetic nanostructure using binding affinity to surface bound chelators.

Single molecular machines are capable of a variety of functions, but methods to couple motion between them are still lacking. Here, Wasioet al. report the emergent behaviour of spontaneously formed two-dimensional crystals, which display correlated switching of their sub-molecular rotor units.

Size control in quantum materials by direct growth is still difficult to achieve. Here, the authors present the width-dependent growth of single-layer nanoribbons of transition metal dichalcogenides from nanoalloy seeds, achieving strain-induced quantum emission with a purity of up to 90 % for single photons.

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

NMR spectroscopy and imaging show that dendrites in a solid-state Li battery are formed from Li plating on the electrode and Li⁺ reduction at solid electrolyte grain boundaries, with an interlapped stalled growth period.

Trees come in all shapes and size, but what drives this incredible variation in tree form remains poorly understood. Using a global dataset, the authors show that a combination of climate, competition, disturbance and evolutionary history shape the crown architecture of the world’s trees and thereby constrain the 3D structure of woody ecosystems.

APOA1 may protect against atherosclerotic plaque rupture by removing cholesterol from plaques and proteases such as MMP2 promote rupture. Here, the authors show that APOA1 interacts with MMP2 in a way which may affect rupture independently of cholesterol.

DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a variety of acute or chronic recordings from humans, nonhuman primates and mice.

Cavity-stimulated Raman spin-flip emission is demonstrated by coupling a negatively charged InAs/GaAs quantum dot to a photonic crystal defect cavity. The emission is spectrally narrow and tunable over a range of about 125 GHz. The process can be made spin selective by tuning the scattered photons to be in resonance with the cavity.

Numerous micro- and macro-scale factors influence soil microbial diversity. Here the authors create a model to demonstrate that fine scale soil moisture influences the carrying capacity of microbes, which then scales up to larger biogeographic patterns.

It is unclear why flying insects congregate around artificial light sources. Here, the authors use high-speed videography and motion-capture, finding that insects fly perpendicular to light sources due to a disruption of the dorsal light response.

Dark-field momentum microscopy makes it possible to spatio-temporally and spatio-spectrally resolve the dark-exciton dynamics in a twisted transition metal dichalcogenide heterostructure.

Current parathyroid hormone (PTH) peptides have limited efficacy due to rapid clearance and short receptor binding. Here, the authors show that lipidation strategies can extend circulation time and receptor engagement, enhancing PTH peptide efficacy in vitro and in vivo

The authors show that behavior and dopamine responses track prospective, but not retrospective, contingency. These results are explained by temporal difference (TD) learning models, indicating that TD errors are a measure of contingency.

Chang et al. show that CD4 T cell exhaustion and senescence develop during chronic Mycobacterium tuberculosis infection. These factors may promote a feed-forward loop that permits increased bacterial replication, further loss of T cell function, both which culminate in recrudescence and disease.

It has been predicted that Josephson junction devices could produce quantized currents in analogy to the Shapiro steps of voltage used to define the voltage standard. These dual Shapiro steps have now been observed in a Josephson junction array.

In-mold electronics often rely on vacuum forming processes, which are traditionally limited to thermoplastics. Here, the authors introduce a vacuum forming method for thermoset materials using frontal polymerization.

When high-harmonic emission from a ZnO crystal is perturbed with a bright squeezed vacuum beam, a comb of super-bunched high-order sidebands is created. This indicates photon bunching and the generation of a non-coherent state at the short wavelength.

The genomic landscape of diffuse gliomas remains to be characterised. Here, the authors perform whole genome sequencing of 403 tumours and identify recurrent coding and non-coding genetic mutations, their associations with clinical outcomes and potential therapeutic targets.