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Whether paternal pre-conceptual SARS-CoV-2 infection impacts sperm RNA content, or effects offspring phenotypes, has not been previously investigated. Here authors report changes in sperm noncoding RNAs in SARS-CoV-2 infected sires and increased anxiety-like behaviors in offspring.

Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO₂ as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO₂ dissolved in seawater that is subsequently converted to succinate in a bioreactor.

Two-dimensional polyamide/lithiated Nafion interphase layers assembled into ultrathin sheets show high-rate, high-capacity Li plating/stripping as well as high energy and power densities, enabling the fabrication of high-performance anode-free Li metal batteries.

Yang et al. use cryo-ET and resolve a unique native architecture of microtubule singlet-to-doublet transition in the basal body of Plasmodium. They reveal the key role of δTubulin and ε-Tubulin in this transition during Plasmodium male gametogenesis.

Embedding is a key step in single-cell Hi-C analysis to identify cell states. Here, the authors benchmark 13 embedding methods in 10 scHi-C datasets. They find that data representation, preprocessing options, and biological settings are often more important considerations than the actual methods.

The role of lysine crotonylation (Kcr) in MASLD pathogenesis remains unclear. Here, the authors identify a PCAF/SIRT7-IDH1 Kcr axis that ameliorates hepatic steatosis by boosting TCA cycle activity, uncovering a new mechanism and therapeutic target for MASLD.

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacteria in mice.

A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Rechargeable sodium-chlorine (Na-Cl₂) batteries hold promise for grid energy storage but face challenges of corrosive thionyl chloride (SOCl₂) electrolytes. Here, authors introduce a non-corrosive ester as an alternative, enabling Na-Cl₂ batteries with a wide temperature range from −40 to 80 °C.

Achieving long-term stability in halide perovskite solar cells remains challenging due to their susceptibility to environmental degradation. Here, the authors fabricate antimony and sulfur-alloyed perovskite films via a sequential ambient-air process, achieving maximum device efficiency of 25.07%.

The local acidic interfacial environment limits oxygen evolution at high current densities. Here, the authors report that intercalating squaric acid anions into NiFe-based electrocatalysts stabilizes the interface, inhibiting acidification and achieving stability for 700 h at 3.0 A cm⁻².

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Here the authors show that rehabilitating nuclear speckles, membraneless organelles involved in mRNA processing and gene regulation, can boost protein quality control and reduce toxic protein buildup, as well as ameliorate models of diseases like tauopathy and retinal degeneration.

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

This study employs in situ cryo-ET to visualize basal body formation and ciliogenesis in multiciliated mouse cells, revealing how the remodeling of microtubule-inner proteins (e.g., CEP41) ensures precise ciliary assembly.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Hydrogen adsorption/desorption behavior plays a key role in hydrogen evolution reaction catalysis. Here, the authors demonstrate the rational balancing of hydrogen adsorption/desorption by orbital modulation for significantly enhanced hydrogen evolution performance.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

Rice stripe virus deploys its SP protein to dismantle SERRATE condensates in rice cells, blocking microRNA production and enhancing viral spread. This discovery reveals how viruses can hijack host phase separation to modulate gene regulation.

Caesium cations promote the coagulation of 2D and 3D perovskite colloids, synchronizing their nucleation kinetics and enabling the formation of homogeneous 2D/3D heterostructured lead-free photovoltaics with a certified power conversion efficiency of 16.65%.

Honeybee behavioral plasticity provides a model to study how brain gene networks regulate behavior. Here, authors show stripe activation in Kenyon cells links gene regulatory networks to behavioral maturation via spatial-cellular coordination.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

Protein–carbohydrate interactions remain challenging to study due to their low binding affinity and non-covalent nature. Now, a genetically encoded bioreactive unnatural amino acid containing sulfonyl fluoride has been shown to crosslink a protein with its bound glycan, offering a solution to probe and exploit protein–carbohydrate interactions.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Charge loss at grain boundaries of kesterite polycrystalline absorbers limits the performance of thin film solar cells. Here, authors report the use of Pd(II)/Pd(IV) redox shuttle to assist the capture and exchange of Se atoms and eliminate vacancy defects, realizing certified efficiency of 14.3%.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

Circularly polarised luminescence (CPL) is essential for asymmetric synthetic photochemistry. Here, the authors integrate white quantum dots with chiral nematic liquid crystal or liquid crystal polymer to achieve single-emitted tuneable full-colour or white CPL for enantioselective polymerization.

Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to dysregulated mTOR, cytoskeletal and lipid transport signaling.

The development of imaging agents capable of clearly defining tumor margins is essential for GBM intraoperative navigation. Here this group identifies GCN5 as a promising molecular target for GBM imaging therefore designs a dual mode nanoprobe for BBB crossing and in vivo visualization of typical GBM tumor boundaries.

Interpreting bone metastases (BMs) from computed tomography (CT) images remains challenging. Here, the authors develop an AI-based Bone Lesion Detection System - BLDS - and validate it in a cohort of 2,518 patients across five hospitals, showing highly sensitive and accurate performance for BM detection from CT scans.

Seo et al. present an approach to regulate the formation and optoelectronic quality of the SnO₂ electrodes, improving electroluminescence and efficiency in perovskite solar cells.

Lip-language decoding systems are a promising technology to help people lacking a voice live a convenient life with barrier-free communication. Here, authors propose a concept of such system integrating self-powered triboelectric sensors and a well-trained dilated RNN model based on prototype learning.

Photo-crosslinking polymerization facilitates precise control of hydrogel formation for various applications including tissue engineering, but most existing photo-crosslinking methods fail to achieve deep-tissue penetration, especially within bone structures. Here the authors report a strategy of low-dose X-ray-activated polymerization that enables deep-tissue hydrogel formation.

Pesticide exposure induces significant alterations in gut bacterial metabolism. Here, the authors perform a multi-omics mapping of pesticide-gut microbiota-metabolite interactions, identifying pesticide-sensitive gut bacteria species and specific metabolic changes in 306 pesticide-gut microbiota pairs.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

Efficient charge separation plays a crucial role in enhancing artificial photocatalysis. Here, the authors report an alkali etching method to construct an electron transfer layer on BiVO₄:Mo photocatalysts, leading to a charge separation efficiency exceeding 90% at 420 nm.

Rechargeable lithium batteries featuring 5 V cathodes offer high energy density yet struggle with stability. Here, the authors formulate an electrolyte incorporating dimethyl 2,5-dioxahexanedioate solvent, which facilitates stable lithium plating and stripping while offering an extended cycle life.

It remains a great challenge to achieve large-scale fabrication of single atom-anchored heterostructured catalysts with high stability, low cost, and convenience. Here, the authors report single iron atom-dispersed Mo-based nanosheets synthesized from a scalable two-dimensional mineral hydrogel approach for hydrogen evolution reaction in alkaline condition.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

There is a lack of studies on the impact of landscape fire PM_2.5 on cardiovascular health. In this nationwide time-series study, short-term exposure to landscape fire PM_2.5 was associated with increased hospital admissions for cardiovascular disease, ischemic heart disease, and ischemic stroke in 184 Chinese cities.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.