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We report the outcome of an international optical observation campaign of a prototype constellation satellite, AST SpaceMobile’s BlueWalker 3, which features a 64.3 m² phased-array antenna and a launch vehicle adaptor.

Asteroid 1998 KY26 is the target of Hayabusa2 extended space mission. Here, authors show that it is smaller and rotates faster than known.

Observations at infrared and millimetre wavelengths of the young protostar HOPS-315 show a gaseous disk captured at the point at which solids are first starting to condense, the t = 0 for planet formation.

To understand the potential for seaweed as a Blue Carbon strategy, the authors quantify carbon burial under 20 globally distributed seaweed farms. They attribute an average of 1.06 ± 0.74 tCO₂e ha⁻¹ yr⁻¹ to seaweed farms, and show increased accumulation of carbon with farm age.

Whole-genome sequences and field experiments focusing on the global invasive forage crop, Trifolium repens, show high levels of genetic variation across continents and parallel signatures of selection in five haploblocks.

Adherens junctions mediate force transmission and connect the cytoskeleton of adjacent cells. This study demonstrates that force transmission can be achieved through direct and functional β-catenin/vinculin interaction in the absence of α-catenin.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Preservation of oral microbiome ancient DNA from Oceania is much better than human ancient DNA. The authors leverage this to demonstrate that oral microbial community composition in Oceania is not only distinct from the rest of the world, but it may also be associated with patterns of ancient human migration in the region.

Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

In this Consensus Statement, a consortium of microbiome scientists discuss current sequencing data sharing policies and propose the use of a Data Reuse Information (DRI) tag to promote equitable and collaborative data sharing.

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

The analysis of radial velocity variations of O-type stars in the Small Magellanic Cloud reveals a large fraction of close binaries, suggesting that binary physics also plays a prominent role in the low-metallicity environment of the distant Universe.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Efficiency of SARS-CoV-2 vaccines has long been attributed to the neutralising capacity of the antibodies that are produced upon prime-boost vaccinations. Here authors show that upon vaccination with CoronaVac and BNT162b2 vaccines in prime-boost regimens, antibodies with Fc-effector functions to enhance cellular and innate immunity are also produced, albeit with different kinetics.

The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.

An ecological analysis of 326 cities in 9 countries across Latin America found that changes in ambient temperature have a substantial contribution to all-cause mortality, with small increases in extreme heat associated with steep increases in mortality risk.

A horizon scan of international respondents identifies and discusses ten developing challenges in Antarctic conservation, revealing an increased emphasis on challenges related to governance, geopolitics and economics compared to a similar scan from 2012.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Passive immunisation for respiratory syncytial virus for infants is recommended by the World Health Organization but products currently available have limited duration of protection. Here, the authors investigate the age distribution of infant hospitalisation for respiratory syncytial virus to inform optimal timing of immunisation.

WD 0032–317B is a 75–88-Jupiter mass companion orbiting a hot white dwarf with a period of 2.3 h. It has a day-side temperature of about 8,000 K and a day–night difference of ~6,000 K. WD 0032–317B is amenable to detailed characterization and can be used as a proxy for strongly irradiated ultra-hot giant planets.

Wildfire burned area was 367 Mha in 2024, ranked 17th since 2001. An estimated 1,965 Tg C was released from these fires, 41% of which came from the Americas, far exceeding their usual 25% contribution.

The shock breakout (SBO) is the first electromagnetic signature of a supernova (SN) explosion. Förster et al. find that in nearly all type II SNe they survey that the SBO occurs on a timescale of days, indicating that the progenitors were surrounded by thick circumstellar matter when they exploded.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Despite high levels of trade, the basic characteristics of the aquatic food trade are largely unknown. Here, the authors present a global seafood trade database showing the increasing globalization of farmed and wild aquatic foods.

Roadways are damaged by temperature extremes, increased precipitation and sea level rise. This Review discusses the mechanisms and impacts of climate stressors on roadways, the resulting operational and maintenance challenges, and strategies to increase resilience.

Direct observations of silicate clouds in the atmosphere of the exoplanet YSES-1 c and the first circumplanetary disk silicate emission around its sibling planet YSES-1 b are reported.

Regions of intense continental deformation, termed continental slivers, have been identified in Chile, Bolivia and Ecuador. Analyses of GPS data now identify another large sliver in Peru, the Inca Sliver, that is moving away from a neighbouring sliver in Ecuador—implying that moving continental slivers control the deformation of almost the entire Andean mountain range.

By day 1,041 after explosion, SN Ia-CSM 2018evt had produced an estimated 0.01 solar masses of dust in the cold, dense shell behind the supernova ejecta–circumstellar medium interaction, ranking it as one of the most prolific dust-producing supernovae ever recorded.

Latin America and the Caribbean remain largely underrepresented in psychiatric genetics research. This Review highlights the need for more research in these populations to advance genetic insights and ensure equitable precision medicine access.

Reducing the stigma and discrimination that people living with liver conditions experience requires rethinking how diagnoses, diseases, etiologies and circumstances are perceived — a shift that begins with the language used to name and describe them.

Differences in the Pace of Aging are important for many health outcomes but difficult to measure. Here the authors describe the Dunedin Pace of Aging Calculated from NeuroImaging measure, an approach that uses a single brain image to measure how fast a person is aging and can help predict mortality or the risk of developing chronic disease.

Carbonate mineral aqueous solubility decreases as carbonates become more Mg-rich during subduction. Coupled with regional variations in amounts of carbon and water subducted, this explains discrepancies in estimates of carbon recycling, suggesting that only around a third returns to the surface.

We analyse a global dataset of genomic DNA sequences for Ophiuroidea to gain an understanding of phylogenetic divergence and biotic movement across oceans, finding phylogentically divergent faunas at shelf depths but greater connectivity of species at deep-sea depths.

Highly pathogenic avian influenza is an increasing global concern but its distribution in remote regions is not known. Here, the authors conduct an environmental influenza surveillance study in remote, uninhabited regions of the Global South by sampling fresh bird guano.

Predictions suggest that a high proportion of plant species will be threatened with extinction in the near future. A global assessment of the threat status of cacti suggests that these iconic plants are amongst the most threatened taxonomic groups, with 31% of the 1,478 evaluated species at risk of extinction.

This study proposes an unreported molecular mechanism of substrate inhibition in enzymes. It shows that a competitive inhibitor reduces substrate inhibition and identifies unique enzyme-substrate complexes, suggesting an unreported paradigm for enzyme regulation.

Protection afforded by inorganic minerals is assumed to make mineral-associated organic carbon less susceptible to loss under climate change than particulate organic carbon. However, a global study of soil organic carbon from drylands suggests that this is not the case.