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Showing 1–50 of 2480 results
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  • The quark structure of the f0(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f0(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

    • A. Hayrapetyan
    • A. Tumasyan
    • A. Zhokin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Cryo-electron microscopy structures of three large ornate natural bacterial RNA molecules reveal their quaternary structures and intra- and intermolecular interactions that stabilize them.

    • Rachael C. Kretsch
    • Yuan Wu
    • Rhiju Das
    ResearchOpen Access
    Nature
    Volume: 643, P: 1135-1142
  • Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

    • Ryan V. Raut
    • Zachary P. Rosenthal
    • J. Nathan Kutz
    ResearchOpen Access
    Nature
    P: 1-8
  • Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

    • B. E. Aboona
    • J. Adam
    • M. Zyzak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Proteins in the fungal plasma membrane are key antifungal targets but their native structure and spatial distribution are poorly understood. Here, Jiang et al. use proteomics and cryo-electron tomography to investigate the organisation of membrane proteins in the fungal plasma membrane and how this is affected by antifungal drugs.

    • Jennifer Jiang
    • Mikhail V. Keniya
    • Wei Dai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • The Zika viral protease NS2B-NS3 is a crucial target for antiviral drug development due to its role in processing viral polyproteins. Here, the authors utilize crystallographic fragment screening and deep mutational scanning to identify binding sites for resistance-resilient inhibitors.

    • Xiaomin Ni
    • R. Blake Richardson
    • Frank von Delft
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

    • Shivendra Singh
    • Jie Fang
    • Jun Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26
  • Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

    • Glennis A. Logsdon
    • Peter Ebert
    • Tobias Marschall
    ResearchOpen Access
    Nature
    Volume: 644, P: 430-441
  • Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state in melanoma.

    • Miranda V. Hunter
    • Eshita Joshi
    • Richard M. White
    ResearchOpen Access
    Nature
    P: 1-11
  • Bio-hybrid photoelectrochemical systems integrate microbial components with abiotic conductors/semiconductors for solar fuels and chemical conversion. Here, the authors analyze the bottlenecks related to catalytic efficiency, stability and scalability, and propose strategies to address these challenges.

    • Bin Cai
    • Mariia V. Pavliuk
    • Haining Tian
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

    • Aaron A. Phillips
    • Aasta P. Gandhi
    • Grégoire Courtine
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2946-2957
  • Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofactor has now been developed as a biocompatible alternative for diazirine activation inside living cells, offering accurate mapping of protein interactors and dynamics with excellent spatio-temporal control.

    • Leander B. Crocker
    • Jan Vincent V. Arafiles
    • Christian P. R. Hackenberger
    ResearchOpen Access
    Nature Chemistry
    P: 1-13
  • Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

    • Boya Guo
    • Yanwei Cai
    • Burcu F. Darst
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The authors assess the impacts of tropical deforestation and its subsequent local warming on human heat-related mortality. They estimate that deforestation-related warming (+0.27 °C) is associated with approximately 28,000 heat-related deaths per year.

    • C. L. Reddington
    • C. Smith
    • D. V. Spracklen
    ResearchOpen Access
    Nature Climate Change
    Volume: 15, P: 992-999
  • The approval of first line immune checkpoint blockade (ICB) has improved outcomes for patients with metastatic non-small cell lung cancer (mNSCLC), however, whether patients would benefit more from ICB alone or alongside chemotherapy is unclear. Here, the authors develop a machine-learning based approach to help guide individual treatment selection patients with mNSCLC.

    • Maliazurina B. Saad
    • Qasem Al-Tashi
    • Jia Wu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • A strongly lensed galaxy at redshift z ≈ 6 is resolved into at least 15 star-forming clumps embedded in a rotating disk. Clump formation in this system, which is not predicted by cosmological zoom-in simulations, may be driven by disk instabilities with weak feedback, rather than past mergers.

    • S. Fujimoto
    • M. Ouchi
    • H. Yajima
    Research
    Nature Astronomy
    P: 1-15
  • A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

    • Joel A. Hurowitz
    • M. M. Tice
    • Z. U. Wolf
    ResearchOpen Access
    Nature
    Volume: 645, P: 332-340
  • In a quantum simulation of a (2+1)D lattice gauge theory using a superconducting quantum processor, the dynamics of strings reveal the transition from deconfined to confined excitations as the effective electric field is increased.

    • T. A. Cochran
    • B. Jobst
    • P. Roushan
    ResearchOpen Access
    Nature
    Volume: 642, P: 315-320
  • Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

    • B. Kool
    • K. Verhaegh
    • V. Zamkovska
    ResearchOpen Access
    Nature Energy
    Volume: 10, P: 1116-1131
  • Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

    • Zheng Li
    • Wee Ling Chng
    • Chiea Chuen Khor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Megaraptoran theropod dinosaur anatomy and evolution is unclear due to the fragmentary nature of most available fossils. Here the authors report a well-preserved, late surviving megaraptoran from Argentina that clarifies our understanding of the morphology of this group and potentially provides insights into its diet and feeding strategies.

    • Lucio M. Ibiricu
    • Matthew C. Lamanna
    • Rubén D. Martínez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • The molecular basis for differences in immune response to SARS-CoV-2 in children and adults is still unclear. Here, the authors show that antibodies are of high binding and functional quality in children with mild or asymptomatic infection, but antibody response is delayed as compared to adults.

    • Carolyn A. Cohen
    • Ludivine Grzelak
    • Sophie A. Valkenburg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • MicroRNA maturation is initiated by the Microprocessor that cleaves primary microRNA hairpins. Here, the authors uncover distinct roles of two auxiliary factors of the Microprocessor, ERH and SAFB2, in the processing of suboptimal clustered microRNA hairpins.

    • Harim Jang
    • Junyoung Park
    • V. Narry Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO2 reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

    • Yao Yang
    • Julian Feijóo
    • Peidong Yang
    Research
    Nature Catalysis
    Volume: 8, P: 579-594
  • Lee et al. show that the circadian clock protein REV-ERBα controls brain NAD+ levels by regulating the NAD+-consuming enzyme CD38. Global or astrocytic REV-ERBα deletion or pharmacologic REV-ERB inhibition protects against tau pathology in mice.

    • Jiyeon Lee
    • Ryeonghwa Kang
    • Erik S. Musiek
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 2070-2085
  • A hybrid analogue–digital quantum simulator is used to demonstrate beyond-classical performance in benchmarking experiments and to study thermalization phenomena in an XY quantum magnet, including the breakdown of Kibble–Zurek scaling predictions and signatures of the Kosterlitz–Thouless phase transition.

    • T. I. Andersen
    • N. Astrakhantsev
    • X. Mi
    ResearchOpen Access
    Nature
    Volume: 638, P: 79-85
  • The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

    • A. Tumasyan
    • W. Adam
    • W. Vetens
    ResearchOpen Access
    Nature Physics
    Volume: 19, P: 338-350
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

    • Inna V. Krieger
    • Paridhi Sukheja
    • Case W. McNamara
    Research
    Nature
    Volume: 645, P: 755-763
  • The natural progression of tumours and their treatment can influence tumour evolution. Here, authors analyse whole-exome sequencing data from various cancer cohorts, finding that treatment-resistant tumors shift toward neutral evolution, which correlates with worse prognosis, and monitoring this shift may guide treatment decisions.

    • Erez Persi
    • Praneeth R. Sudalagunta
    • Eugene V. Koonin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

    • Lucia Trastulla
    • Georgii Dolgalev
    • Michael J. Ziller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-28
  • Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

    • Camille Ezran
    • Shixuan Liu
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 185-196
  • Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and Crohn’s disease prognosis.

    • Frank Dudbridge
    • Richard J. Allen
    • Riyaz S. Patel
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

    • R. Aaij
    • A. S. W. Abdelmotteleb
    • G. Zunica
    ResearchOpen Access
    Nature
    Volume: 643, P: 1223-1228
  • During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

    • Yu Wang
    • Vinay V. Eapen
    • Zhixun Dou
    Research
    Nature
    Volume: 644, P: 780-789
  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712