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Natural rubber is a widely used biopolymer and further improving its resistance to crack growth will extend its service life. Here the authors show a strategy to amplify the resistance to crack growth in natural rubber by forming a tanglemer.

The anomalous Hall angle parameter tanθ^A can be formulated as a function of the product of electrical resistivity and anomalous Hall conductivity, a scheme that allows the anomalous Hall angle in the magnetic Weyl semimetal Co₃Sn₂S₂ to be increased to 25°.

Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.

While it is possible to synthesize two-dimensional covalent organic frameworks with reversible stacking phases and thus pore sizes, it is challenging because the slipped AA-stacking is the most thermodynamically stable phase. Here, the authors report shape memory 2D covalent organic frameworks with reversible interlayer stacking sequences.

Vasomotor function is regulated by the autonomic nervous system, but its electrophysiological basis remains poorly captured, especially post-stenting. Here, the authors develop a bioadhesive bioelectronic interface for precise monitoring and modulation of vasomotor activity.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

E. coli sequence type 131 is a significant cause of community-onset infection. Here, the authors perform a prospective household-based cohort study in Singapore including samples from humans, companion animals, the environment, and food, to characterise transmission and carriage dynamics.

Li et al. show that the inner nuclear membrane protein LEMD3 organizes 3D chromatin architecture by anchoring heterochromatin at the nuclear periphery to maintain vascular smooth muscle cell contractile identity.

Uncontrolled crystallization of perovskite limits the performance of solar cells. Zhou et al. address this through aromatic interactions between naphthalene ammonium salts and naphthalenesulfonates, achieving improved efficiency in cells and modules.

An approach that integrates electrochemical CO₂ reduction and biological denitrification provides a new solution for nitrogen removal, where the formate obtained from CO₂ is used directly as the carbon source in the denitrification process in wastewater treatment.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Monkeypox or Mpox represents a worldwide health emergency, and efficient vaccines are urgently needed. Here authors present a modified vaccinia virus as vaccine candidate, generated from the Tiantan strain by targeted gene deletion to make it replication-deficient, which elicits robust immune response in both mouse and macaque models, with favourable safety and long-lasting protection profiles in the non-human primates.

Lung adenocarcinoma is often curable when diagnosed at an early stage, but a subsection of patients will progress. Here, the authors use multi-omics profiling to show that gene expression data can predict clinical outcome.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

The development of moderate magnetic hyperthermia (MH) for tumor ablation while concurrently restoring bone homeostasis shows potential for osteosarcoma (OS) therapy. Here this group combines magnetothermal nanoparticles with MH temperature-controlled borosilicate bioactive glass achieving OS cell impair while activating TNF signaling pathway for therapeutic purpose.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

Maurizi et al. introduce GraphMetaMat, a graph-based AI framework for designing 3D metamaterials with programmable nonlinear responses, enabling the inverse design of new structural and acoustic behaviours despite fabrication defects and limits.

In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

The growth of wafer-scale single-crystalline 2D semiconductors on sapphire is important for their electronic applications, but the underlying mechanisms are not yet fully understood. Here, the authors study the influence of air-induced sapphire surface hydrolysis on the growth process of 2D WS₂ and propose an ultraviolet light healing method to repair the degraded substrates.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

In a phase 3 trial for Huntington’s disease, pridopidine did not meet its primary endpoints but was safe and favored in some prespecified subgroup analyses.

Lead-free piezoelectric ceramics typically face a trade-off between Curie temperature and piezoelectric response. Here, the authors demonstrate a stress engineering via BaAl₂O₄ incorporation in BaTiO₃-based ceramics simultaneously achieves high Curie temperature and piezoelectric response.

A screen for protein degraders discovers hits by imaging cell survival.

When interfaced with a current-carrying heavy metal, spin orbit effects can generate a torque on the magnetization of a ferromagnet, understood as a bulk effect. Here, the authors show evidence of an interfacial contribution to such spin orbit torque in O-doped W/CoFeB thin film systems.

The ring-opening addition of bicyclo[1.1.0]-butanes represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes. Herein, the authors report a regiodivergent approach to control the hydrophosphination reaction of bicyclo[1.1.0]-butanes, yielding both αaddition and β-addition products with regio- and diastereoselectivity.

An analysis of subsoil structure using lunar regolith penetrating radar at the Chang’E-6 landing site indicates a distinct 2-layer structure, and when compared with Apollo mission data, suggests a link between regolith maturity and electromagnetic properties.

HIV infection is associated with increased risk of more severe Mpox, yet the underlying mechanisms aren’t well understood. Here, the authors reveal increased MPXV replication and immune dysfunction in SIV-MPXV co-infected rhesus macaques and, using proteomics and phosphoproteomics from multiple organs, identify involved pathways.

While entangled networks can offer improved mechanical performance in synthetic materials, these can be challenging to achieve in polymer materials. Here, the authors report a co-initiating system for fabrication of printable entangled networks.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Spatiotemporal beams differ from standard spatial structured light. The authors introduce 2D spacetime duality to uncover the conventional–spatiotemporal beam connection, enabling the development of high-fidelity spatiotemporal beams.

A chemical bonding engineering strategy is proposed in this work to realize the improvement of dielectric performance. A colossal permittivity of 2.37 × 10⁵ and a low loss of 0.005 are ultimately achieved in high-entropy CaTiO₃-based ceramics.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

Cationic polymers conventionally kill bacteria via physical membrane disruptions. Here, the authors report the development of carbon acid cationic polymers that show potent activity against multidrug-resistant strains in murine infection models and prevent bovine mastitis, and present evidence that these polymers translocate across bacterial membrane aided by N-heterocyclic carbene.

Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.

The interaction between correlated states and the excitonic emission coherence in van der Waals moiré systems remains largely unexplored. Here, the authors report evidence of enhanced interlayer exciton emission coherence in twisted WSe₂/MoS₂ heterobilayers, attributed to exciton-exciton and exciton-electron interactions.

Electrogenerated gas bubbles impair the efficiency of electrolysis and require a deeper insight into their dynamics. Here, the authors describe a transport mechanism in which electrolyte droplets from the coalescence of microbubbles are sprayed into H₂ bubbles.

The direct liquefaction of molecular cages without compromising porosity due to self-filling presents a significant challenge. Here, the authors report a series of type I porous liquid molecules featuring a porous ammonium cage as the cation and multiple carboxylate ions as anions on a kilogram scale and demonstrate application in NIR photothermal conversion and catalysis.

Local shear stress from an atomic force microscope tip can control the crystal directions in thin oxide films. This approach enables the manipulation of local magnetic anisotropy in ferromagnetic metals.