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Large pore metal–organic frameworks may have improved catalytic or molecular sieving properties. Here, the authors demonstrate that carbon dioxide expanded liquids can be used to synthesize these materials and that pore size may, to an extent, be tuned by varying gas pressure.

The authors present a magnetic crack-based piezoinductive sensor which detects bidirectional bending with a precision of 0.01° from −200° to 327°, showing maintained performance when submerged in hot and cold water, scratched in half, or run over by a car.

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-purpose dyes for fluorescence biomaging.

Gastric cancer detection by endoscopy is intrusive and time-consuming, and early detection is key to improving survival. Here, the authors propose a metabolite-based model to enable early detection.

Zhao, Chai and colleagues. show that proline regulates hepatic gluconeogenesis by modulating mRNA retention in paraspeckle structures, thus contributing to glycaemic control in type 2 diabetes.

Knowledge about the fate control of GABAergic neuron subtypes during development and pathogenesis is limited. Here authors reveal Foxg1 regulates transcriptional programs that direct lineage bifurcation.

The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.

Yolk sac tumours are a type of ovarian germ cell tumours. Here, the authors perform exome and RNA sequencing of clinical samples of 30 patients, characterize the mutational landscape of these rare tumours, and identify molecular features associated with resistance to cisplatin-based therapies.

Urinary proteomics offers sensitive, non-invasive biomarkers, but cross-platform LC-MS data comparability requires investigation. Here, the authors evaluate 20 LC-MS platforms, developing MSCohort, a QC system with 81 metrics, and a unified SOP, paving the way for precision medicine research.

The fabrication of perovskite solar cells in ambient air is of interest, but the materials are unstable in the presence of moisture. Yan et al. show that guanabenz acetate salt eliminates vacancy defects that trigger perovskite degradation, enabling 25% efficiency devices to be fabricated in air.

COVID-19 pandemic is a global health risk, but our understanding on the induced durable immunity remains scarce. Here the authors assess antibody responses in 869 convalescent COVID-19 patients to find that specific antibody titers reduce with time, and the RBD-IgG positive rate exceed 70% at 12 month post diagnosis, with male and older patients showing stronger responses.

In this study, the authors report the development of an inhalable IgM-like ACE2 and show that it broadly neutralizes SARS-CoV-2 variants, lowers viral loads and lung pathology in hamsters when administered early, and has good safety profiles in rats and monkeys.

Dong and colleagues describe how T_FH cells initially interact with dendritic cells in colonic lymphoid follicles and further differentiate into long-lived pathogenic T_H1 cells, promoting the progression of colitis.

Presymptomatic transmission of SARS-CoV-2 is estimated to account for a substantial proportion of COVID-19 cases.

Mudskippers are amphibious fishes that have adapted to live on mudflats. Here, the authors sequence the genomes of four different mudskipper species and highlight genetic changes that may have had an evolutionary role in the water-to-land transition of vertebrates.

Combining a double-ring modulated SPIM with reduced side lobes and a sectionalized deep-learning based super-resolution algorithm enables fast, high-resolution, volumetric imaging of organelle interactions and dynamics in live cells.

The decomposition of perovskite materials during annealing could impact on their stability. Here, the authors adopt a molecular creeper to inhibit perovskite decomposition by suppressing the escape of cations, achieving certified efficiency of 25.36% for solar cells with operational stability.

There’s a trade-off between the sensitivity and bandwidth for mechanics guided sensor designs. Here, authors report a mechanical sensor comprised of piezoelectric resonators with near infinite effective piezoelectric coefficients, leading to highly sensitive and broadband micromotion sensing.

New data reveal a sequential mode of alternative polyadenylation. Distal polyA sites are processed first and the resultant transcripts are retained in the nuclear-chromatin matrix for subsequent cleavage and polyadenylation at proximal polyA sites.

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.

Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in golden Syrian hamster.

Insect salivary protein (BISP) targets OsRLCK185 to suppress defence in susceptible plants, whereas in resistant plants BISP binds BPH14 to activate host plant resistance. To restore cellular homeostasis, the resistance mechanism is fine-tuned by selective autophagy.

High crosslinking and low shrinkage stress are difficult to reconcile in the preparation of performance-enhancing photopolymer materials. Here the authors report the mechanism of upconversion particles-assisted NIR polymerization in reducing shrinkage stress and enhancing mechanical properties of cured materials

Castor is an important industrial oil crop, but knowledge on its genetic diversity is limited. Here, Fan et al. show geographic pattern of Chinese castors that have developed during domestication by population genetic analyses, and reveal candidate genes associated with agronomically important traits.

Atomically thin black phosphorus shows promise for optoelectronics and photonics, yet its instability under environmental conditions and the lack of well-established large-area synthesis protocols hinder its applications. Here, the authors demonstrate a stable black phosphorus ink suitable for printed ultrafast lasers and photodetectors.

Palladium can catalyse both the reductive carbonylation of aryl halides to aldehydes, and the reductive amination of benzaldehydes with amines. Here the authors describe a tandem reductive carbonylation/reductive amination using carbon monoxide as the carbonyl source, constituting aminomethylation of aryl halides

Carbonylative homologation reactions are typically catalysed by precious metal catalysts such as palladium and rhodium. Here, aryl iodides are reductively homologated using a nickel triflate catalyst and simple bipyridine ligand, using Mo(CO)₆ as the carbonyl source and phenyl silane as the reductant.

A six-helix bundle DNA structure called meta-DNA has now been assembled and shown to possess some structural properties similar to those of single-stranded DNA. Two meta-DNAs containing complementary ‘meta-base pairs’ are shown to form double helices. Meta-DNA building blocks are also used to construct a series of DNA architectures and to perform a hierarchical strand-displacement reaction.

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Esophageal squamous cell carcinoma (ESCC) exhibits differences in incidence and survival patterns among races. Here, analysis of Chinese and TCGA ESCC patients reveals that Asian patients exhibit higher TP53, EP300 and NFE2L2 mutational frequencies, and mutated CSMD3 associates with better prognosis.

RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.