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Substrates with blastocyst-like microstructures effectively revert primed pluripotent stem cells to naivety by promoting cell–cell apical constriction and mechanoinduced epigenetic activation of naive pluripotency genes.

Efferocytosis describes the engulfment and clearance of apoptotic cells by phagocytes. Here the authors identify in primary mouse macrophage WDFY3 as a regulator for efferocytosis, in which c-terminal WDFY3 is sufficient to modulate degradation while full-length WDFY3 is required to modulate the uptake of apoptotic cells.

Thin films of halide perovskites are promising for solar cell technology but they do not perform well at the band edge due to the low optical absorption. Herein, Chen et al. fabricate a high efficiency single crystal perovskite solar cell with thicker single crystals to harvest the below-bandgap photons.

Porous 2D materials hold great potential for applications in catalysis and electronics. Here, the authors design a novel inorganic framework in which POM clusters function as “electron buffers” to stabilize active sites and reduce the energy barrier for toluene oxidation, paving the way for programmable catalytic materials with tailored electronic properties.

A recycling strategy based predominantly on the use of water to restore and reuse valuable components from perovskite photovoltaic waste is described, with recycled devices showing similar efficiency and stability compared with fresh devices.

An electrocatalyst mediator system in which CoO_x-cluster-decorated IrO₂ activates the NO₃^- mediator into a reactive radical that abstracts a hydrogen atom from benzylic C-H is presented. This approach enables the electrochemical conversion of toluene to benzaldehyde with high Faradaic efficiency.

Symbiotic nitrogen fixation is a tightly regulated process serving as a sustainable source of nitrogen (N) in agriculture. Here it is shown that external N sources precisely regulate N fixation efficiency by modulating iron transport in nodules of legumes.

There is a clear need for rapid, accurate and scalable Covid-19 diagnostics. Here the authors use PfAgo to detect viral sequences amplified by RT-LAMP in a handheld battery-powered device.

The development of PVC-like plastics that can be depolymerized back to monomer contributes to a circular plastic economy but remains understudied. Here, the authors develop a series of chemically recyclable plastics from the reversible copolymerization of cyclic anhydride with chloral.

The authors uncover one of the largest mitoribosomes, dedicated to translating only three proteins in lethal human eukaryotic pathogens of the Apicomplexa phylum. All members of mitochondrial DNA-containing Myzozoa, including Toxoplasma gondii, have commandeered three lineage-specific families of RNA-binding proteins to meticulously piece together over 40 mitochondrial rRNA fragments to build an operational mitoribosome.

Existing organic long-persistent luminescence systems do not align with human scotopic vision. Here, authors achieve blue-shifted emissions in binary systems by upconverting charge-transfer to locally excited singlet state, with a strong luminescence under international standard for safety signs.

Interfaces can give rise to novel states of matter not found in bulk materials. Here, the authors use microwave impedance microscopy to show that the conductivity at charge-order domain walls in a layered manganite is higher than in the rest of the material, due to local lifting of the charge order.

The role of microbial β-diversity in soil ecosystem function is not well-studied. Here, the authors use genetic data to show that microbial α-diversity levels may have impacts on stochastic/deterministic assembly processes and functions of soil microbiome.

Ulcerative colitis is associated with increased infiltration and cellularity, yet the precise tissue topology remains poorly understood. Here the authors employ imaging mass cytometry and single-cell RNA sequencing to characterise intestinal lesions in patients with ulcerative colitis, and show the architecture at the individual cell level which includes a decrease in the resident macrophage population.

Flavin-dependent halogenases (FDHs) in nature produce organic halides under benign conditions, yet their practical application remains elusive and difficult to scale up. Inspired by FDHs, here the authors develop a biomimetic aerobic oxidative halogenation strategy that uses oxygen from the air to oxidize non-toxic halide salts.

Multiple resonance (MR) emitters with narrowband luminescence typically suffer from inadequate frontier molecular orbital levels. Here, authors incorporate cyano motifs at peripheral sites of the MR backbone to adjust the energy levels, realizing device efficiency of over 23% for stable devices.

Adipose tissue fibrosis is connected to obesity-related metabolic dysfunction. Qiu and colleagues discover that the Hippo pathway acts as a molecular switch in the initiation and development of adipose tissue fibrosis upon TGFβ stimulation.

What happens to correlated electronic phases—superconductivity and charge density wave ordering—as a material is thinned? Experiments show that both can remain intact in just a single layer of niobium diselenide.

Subsoils are vital for ecosystem sustainability due to their nutrient stocks and microbial diversity. This study across 40 agricultural sites in China found that, compared with topsoils, subsoils are more sensitive and variable under disturbance, highlighting the need to manage both layers in sustainability efforts.

A Stereo-seq and scRNA-seq atlas of mouse liver in homeostasis and regeneration after partial hepatectomy identifies zonated genes, pathways, cell–cell interactions and gene regulatory networks. Functional validation finds that cooperation between TBL1XR1 and β-catenin activates hepatocyte proliferation.

Atomically intimate assembly of FeO_x-Rh-ZrO₂ dual interfaces by selectively architecting highly dispersed FeO_x on ultrafine raft-like Rh clusters supported on tetragonal zirconia enables highly efficient tandem conversion of syngas to ethanol.

Ruddlesden popper layered perovskites can be used in optoelectronic devices, but the understanding of their lattice strain as well as ferroelasticity is still lacking. Here, the authors find ferroelasticity in layered perovskites with layer number more than one and reveal its mechanism.

A library of clusters based on anisotropic polyoxometalate clusters is synthesized. Different phases of superstructures are prepared by tuning interactions between and inside the polyoxometalate building blocks, which adds to our understanding of structure–property relationships at sub-nanometre scale.

AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 and CDS2) form functional complexes that promote further conversion of PA along the CDP-DAG pathway of phospholipid synthesis.

The oncogenic activity of Hexokinase 2, the first rate-limiting enzyme of glycolysis, requires its mitochondrial localization. Here, the authors show that SUMOylation of hexokinase 2 disrupts its binding to mitochondria and protects cells from tumorigenesis in prostate cancer.

Recently exceptional plasticity has been discovered in defective Bi₂Te₃ crystal. Here, the authors further investigate the plasticity of other Bi₂Te₃-family compounds and then determine the composition range with good plasticity, high power factor and figure-of-merit.

Zheng and colleagues report that targeting both the death domain and the paracaspase domain of MALT1 with antisense oligonucleotides sensitizes resistant tumors to immune-checkpoint inhibition.

The adaptation to atomically thin 2D semiconductors and van der Waals layered ferroelectrics can enable negative capacitance transistors with superior performance and bendability. Here, the authors report flexible negative capacitance transistors based on MoS2 and a ferroelectric dielectric CIPS with a minimum sub-threshold slope of 28 mV/dec and high gain logic invertors.

Exercise could affect the immune system, but whether early-life exercise could benefit immune health in adulthood is not fully understood. Here the authors show that early-life exercise promotes epi-metabolic changes in the liver to potentially benefit immunity in older age and characterise the involvement of pipecolic acid in this process.

Although the efficacy of chimaeric antigen receptor (CAR) T cell therapy has been demonstrated in relapsed/refractory diffuse large B-cell lymphoma (DLBCL), it has not been investigated in primary refractory DLBCL. In this phase I clinical trial, the authors report on the safety and efficacy of relmacabtagene autoleucel, a CD19-specific CAR T cell product, and demonstrate using single-cell RNA sequencing that cholesterol efflux from macrophages may impair CAR T cell responses in this context.

Solvating polar polymers with ionic liquids at appropriate concentrations can produce a unique class of materials called glassy gels with desirable properties of both glasses and gels.

The early signalling events following ethylene perception by plants remain incompletely understood. Here the authors show that in the absence of ethylene, rice MHZ3, a known stabilizer of OsEIN2, promotes phosphorylation of OsCTR2 to suppress ethylene signalling.

Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of the antibody.

Transparent conductive electrodes are widely used in modern optoelectronic devices, but they are rarely transparent in the near-infrared, limiting their use. Nanostructured bismuth selenide, a topological insulator, is now shown to be a flexible near-infrared transparent electrode.

Cell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by snRNAseq, snATAC-seq and Stereo-seq.

Pei et al. show that rhythmic redox signalling controls CLOCK through endogenous H₂O₂ oscillations via reversible oxidative modifications, and that p66^Shc modulates the rhythm of H₂O₂ levels.

The mismatch between solid bioelectronics and biological tissue presents a grand challenge to current skin electronics. Here, we developed a reconfigurable liquid cardiac sensor capable of adapting to biological tissues, allowing ambulatory cardiac monitoring.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.

Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.

A VO₂-based dynamic regulator achieves color-thermal multispectral camouflage spanning the visible and infrared spectra.

This protocol describes a general approach to prepare sub-nanostructures with diverse shapes (nanowire, nanosheet, nanobelt, nanotube or clusterphene) and properties (gelation or catalysis) by controlled assembly of polyoxometalate clusters.

Wang, Zhang, Zheng et al. demonstrate that tumour cell-derived lymphotoxin-β activates NF-κB2 signalling and CCL2/5 secretion in osteoblasts to promote bone metastasis in breast cancer, which may potentially be targeted with a decoy receptor in vivo.

Available eddy-resolved simulations predict turbulent flows accurately but are too computationally demanding for widespread application. This study presents a Conditional Neural Field Latent Diffusion model that efficiently simulates complex spatiotemporal dynamics in turbulent systems, even within challenging 3D irregular domains.

Incorporating immiscible metals in high-entropy oxides creates unique catalytic sites but results in low specific surface areas due to the high formation temperature. Here the authors report low temperature synthesis of periodically aligned high-entropy LaMnO3 oxides and polyoxometalate heterostructures for photoelectrochemical coupling of methane into acetic acid under mild conditions.

A Li⁺-assisted liquid-phase reduction method is reported, which converts crystalline metal oxides into amorphous metal oxides. The electrostatic interaction between the naphthalene radical anions and Li⁺-inserted metal oxides is found to promote the amorphization process.

Periodic laser light can modify the electronic properties of solids and offers a path to create new material phases. In a topological antiferromagnet, periodic driving with opposite light helicities is now shown to produce distinct Dirac mass gaps.

A LaCl₃-based lithium superionic conductor is developed that has excellent interfacial compatibility with lithium metal electrodes, with its optimized Li_0.388Ta_0.238La_0.475Cl₃ electrolyte exhibiting good Li⁺ conductivity and low activation energy.