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This paper presents an active pixel power control (APPC) to minimize crosstalk in all-optical neural interrogation. Tested in vivo, APPC suppresses optogenetic artifacts while preserving Ca2+ imaging quality, enabling precise neural circuit analysis.

Unambiguous identification of double-strangeness hypernuclei is a challenging task in nuclear physics. Here, the AUs demonstrate identification of 13ΛΛ-B hypernuclei from an AI pipeline applied to the analysis of nuclear emulsion data from the JPARC-E07 experiment.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

The authors leverage experimental and phylogenetic data to propose that anammox bacteria during the Archaean period could have harvested photoholes from cyanobacterial mats for use as an electron acceptor prior to the availability of nitrite.

Anhydroicaritin-loaded mesenchymal stem cell exosomes attenuates IMQ-induced murine psoriasis-like skin inflammation and acted as a therapeutic candidate for psoriasis management.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Here, the authors identify a methane-consuming human gut bacterium, Methylocystis intestini, showing it can affect digestion and fat metabolism by regulating gut methane levels, revealing a natural gut microbial potential mechanism helping maintain healthy gut function and balance.

Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promoting extracellular matrix (ECM) organization and facilitating bone regeneration through matricrine effects.

SARS-CoV-2 continues to evolve, necessitating updated vaccines and therapeutics. Here the authors identify three broadly binding antibodies from vaccinated or infected individuals, characterize their conserved non-overlapping RBD epitopes by structural analysis and demonstrate protective effects in a hamster model.

A manually operated portable water disinfection system can rapidly inactivate pathogens in water, offering a promising approach for safe water treatment in low-resource settings.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

The authors present the adaptive optics system MD-FSS, which allows high-resolution brain imaging in awake mice with rapid aberrations correction against motion. It reveals differences in brain function between awake and anesthetized states, improving our understanding of neurovascular dynamics.

Solid electrolytes play a crucial role as ion conductors and separator between electrodes in all-solid-state batteries. Here, the authors report a high-entropy halide solid electrolyte, which reveals the structure evolution with the increasing configurational entropy and improves the high-voltage stability.

This work introduces Deep-STARmap and Deep-RIBOmap, imaging-based sequencing platforms designed to profile transcriptional and translational activity in thick tissue blocks.

Allylic amination of unactivated alkenes with aliphatic amines is a long-standing synthetic challenge in organic chemistry. This is now accomplished in an oxidant-free, site-selective process by using a combination of a photocatalyst and cobalt complex for the coupling of olefins and alkyl amines with hydrogen evolution.

Injectable hydrogels are being explored for Rheumatoid Arthritis (RA) therapy, but most existing injectable hydrogels address only specific aspects of the RA pathological microenvironment. Here, the authors report an injectable bioadhesive and lubricating hydrogel, that prevents cartilage wear, provides long-term anti-inflammatory effects, and repairs damaged cartilage for RA therapy.

Precise separation of ions with similar valence and size is critical. Here, authors designed a selective membrane that precisely extract Li+ from Na+ and Ca²⁺ interferences. The high selectivity and permeability enable energy-efficient, precise, and chemical-free lithium extraction using the electrodialysis process.

Chondrocyte senescence is known to play a role in the occurrence and progression of osteoarthritis. Here, the authors demonstrate that 10-hydroxy-2-decenoic acid (10-HDA), a small molecule derived from the food nutrient royal jelly, can prevent osteoarthritis by delaying chondrocyte senescence through targeting aspartyl β-hydroxylase.

Off-target effects have limited RNA degradation approaches. Here, the authors develop a tumor microenvironment-activated ribonuclease targeting chimera (RiboTAC) demonstrating H₂O₂ and acid activated degradation of pre-miR-21, which was effective in restoring radiosensitivity in lung cancer.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Design and synthesis of non-noble metal catalysts is crucial for highly-efficient hydrogenation. Here, the interstitial sites in nickel are manipulated with zinc and filled by dissociated carbon atoms, which drastically improve the selectivity/stability in acetylene hydrogenation reaction.

Mouse B cells can be reprogrammed via Cas12a to express human antibodies that when affinity-matured in recipient mice generate broader and more potent antibody variants.

This work introduces roll-to-roll fluidics, a method that enhances reagent efficiency and reduces turnaround time, enabling rapid and economical next-generation sequencing.

Biomaterials have potential in treating periodontitis in diabetes, but addressing the range of issues with one material is challenging. Here, the authors report the development of a redox-active hydrogel for reducing inflammation and promoting tissue regeneration in diabetic periodontitis.

Photonic memristor arrays fabricated from hexagonal boron nitride/silicon heterostructures provide a scalable, silicon-compatible solution for artificial vision systems, featuring broad spectral reconfigurability and promising performance characteristics.

Ethanol steam reforming (ESR) reaction is an environmentally benign and sustainable route for H₂ production. Herein, the authors demonstrate a conceptional strategy for rational design and preparation of highly-efficient catalyst toward ESR via an RhNi-TiO₂ strong bimetal-support interaction.

Sintering-resistant Au nanoparticles are highly desirable due to their low Tammann temperature. Here, the authors report an ultrastable titania-supported Au nanocatalyst through an encapsulation strategy under oxidative atmosphere.

Liu et al. developed AI-driven, wearable olfactory interfaces with odor generators for realizing latency-free mixed-reality and fast olfaction recovery. This technology enables personalized olfactory feedback and enhanced virtual environments for various applications including education, and clinical treatment.

A vanadium-based lithium-rich disordered rock salt oxide is shown to work as a low-potential anode with rapid intercalation kinetics for lithium-ion batteries.

Quantum states are incredibly sensitive to their environment, making them perfect for ultrasensitive quantum detection—if they can be maintained long enough. Here, the authors showed that they can ‘immortalize’ the excited state of a coupled light-matter system using a technique called ‘coherent perfect absorption’.

In this study, the authors develop a comprehensive taxonomy of brain-wide SPNs, identifying several novel subsets via their transcriptional signatures.