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The authors find that electric-field gating-controlled lithium intercalation can switch FeSe reversibly between a nonmagnetic superconducting state and a high-temperature superconducting ferromagnetic state. Further, scanning-SQUID magnetometry reveals that the ferromagnetic domains survive deep in the Meissner state and coexist spatially.

Nickel-rich Li-ion positive electrodes face challenges such as high cost and poor cycling stability. Here, authors show that quenching heat treatment can lead to more stable performance at high voltages, with synchrotron analyses revealing the roles of surface chemistry and bulk charge distribution.

A smartphone-controlled ingestible capsule can have a two-way communication with engineered microbes inside the gut via light-induced signals.

An operando mass spectrometry technique, along with molecular dynamics simulations, unveils the evolution of the solid–electrolyte interphase chemistry and structure in lithium-ion batteries during the first cycle.

Neoadjuvant cancer therapeutic strategy has been explored in phase I/II clinical studies for head and neck squamous cell carcinoma. Here this group reports a single-arm, phase II clinical trial evaluating the neoadjuvant radiotherapy plus PD-1 inhibitor tislelizumab combined with paclitaxel and cisplatin, followed by radical surgical resection on 28 patients with untreated stage III-IVB head and neck squamous cell carcinoma.

The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and immune cells from SAA patients and assess how these phenotypes change after treatment showing alterations in myeloid cells and TCR clonal abundance correlate with robustness of hematopoietic response.

The efficacy of anticancer gene therapy varies by the delivery efficiency of the mRNA cargo as well as their injection method. Here this group reports using LNP-delivered mRNA encoding 3 C protease treated on three different types of solid tumor models showing effective tumor growth inhibition, with three different injection methods, respectively.

The intrinsic instability of wide-bandgap perovskite solar cells is predominantly attributed to the vacancy defects caused by multiple ion migration. Here, authors incorporate an ether ring supramolecule into perovskites and achieve an efficiency of over 28% for all-perovskite tandem solar cells.

VEXAS syndrome is a clinically heterogeneous inflammatory condition caused by mutations in the UBA1 gene. Here, by single cell transcriptomics on peripheral blood cells from VEXAS patients, the authors reveal innate and adaptive immune dysregulations irrespective of UBA1 mutations, including the presence of functionally impaired monocytes and clonal expansion of UBA1 wild-type effector memory B cells and plasmablasts.

NAD⁺ deficiency impairing Sirt6 function reveals the mechanism of in vitro culture-induced telomere shortening in preimplantation embryos, providing a target to improve IVF outcomes.

Cervical thymi are secondary sites of T-cell development in mice. Here, the authors investigate previously unknown origin of cervical thymi and show that they develop as a by-product of the normal separation of thymic and parathyroid tissue.

A selective shielding strategy achieves the differentiation and quantification of distinct plasmonic photocatalytic mechanisms including hot carrier-driven photochemistry, resonant field-mediated energy transfers, and thermal contributions.

Preparing triangulene-based high spin structures is of interest for molecular spintronics. Here, the authors generate high spin triangulene trimers on Au(111) via a surface-assisted dehydration reaction.

Enhancing the stability of positive electrodes at thermally-abused conditions is vital for next-generation lithium-based batteries. Here, the authors report in situ physicochemical characterizations to improve the fundamental understanding of the degradation mechanism in polycrystalline Ni-rich cathodes.

cfDNA is a promising tool to detect early cancer, however, it has been limited by detection limits and technological ability. Here, the authors develop a method for simultaneous cfDNA methylation, fragmentation and copy number alteration sequencing and apply to a cohort of healthy and cancer patients.

This study presents BOOST, a rapid and robust expansion microscopy workflow using microwave-accelerated chemistry to achieve a single-step 10-fold expansion of cells, tissue sections, and FFPE sections. The workflow enables high-resolution visualisation of biological structures and is adaptable for broad applications.

The electrochemical performance of aqueous zinc ion batteries is limited by water activity. Here, the authors propose a hybrid electrolyte that incorporate strongly polar molecules to strengthen the water O–H bonds, thus reduce water activity and improve the electrochemical performance of the batteries.

A ketogenic diet can reduce calorie absorption and protect against obesity by inducing changes to the gut microbiota and the bile acid pool.

Resistance to Herceptin represents a major challenge for successful treatment of HER2-positive breast cancer. Here, the authors demonstrate that the activation of the IGF2/IRS1 signal caused by disruption of a negative feedback loop between FOXO3a-miR-128/miR-30/miR-193 induces Herceptin resistance.

Lithium-metal batteries represent a promising next-generation power source, but there is a trade-off between their energy density and cyclic stability. Now, an electrolyte designed to feature large solvation clustering structures enables a large lithium-metal pouch cell with a boosted energy density of 500 Wh kg⁻¹ and an extended lifespan.

Metabolites can be used to estimate disease risk. Here, the authors use Mendelian randomization to infer the potential causal effects of 1099 plasma metabolites on the risk of 2099 binary disease endpoints.

Hydrogen peroxide (H₂O₂) is a green oxidant with diverse applications. Aided by a nickel phosphorus trisulfide nanosheet electrocatalyst, this work shows a sustainable synthetic route to produce H₂O₂ from seawater with high yield and impressive stability.

Short prokaryotic Argonaute and Sir2 proteins function as an antivirus system. Here the authors describe structures of SPARSA (a heterodimer of Sir2-APAZ and prokaryotic Argonaute) with and without template DNA and guide RNA, providing structural basis of its assembly and activation by the recognition of the invading virus.

Sialoglycan receptor binding promotes the D2 domain up conformation in the HKU1 coronavirus spike protein. Here the authors show that this conformational change is driven fundamentally by the full structuring of the canonical embecovirus binding site.

The authors report the large low-field-driven electrocaloric effect in the novel organic-inorganic hybrid TMCM-CdCl₃, underlyingly from the disordering of organic cations and the low-symmetry interaction induced two-step meta-electric transition.

Moiré lattice reconstruction on mesoscopic length scales gives rise to diverse exciton signatures within emergent domains of different dimensionality.

RORγt+ group 3 innate lymphoid cells are intimately involved in intestinal homeostasis, their dysregulation is linked to inflammatory gut diseases. Here the authors show that dysregulated Wnt/β-catenin signalling contributes to disturbed regulation of group 3 innate cells and intestinal inflammation.

A metal–organic framework (MOF)–pillar[5]arene hybrid can bind small molecules with long alkyl chains, such that single-crystal structures of the host–guest complexes can be obtained and therefore small molecular structures determined.

Variation in cortical surface area in adults can reflect developmental events occurring during prenatal and early postnatal periods. Here, the authors find rare copy number variants associated with cortical surface area, which are also found to disrupt neural progenitor proliferation during fetal development.

Industry-level water splitting requires highly active and stable hydrogen evolution reaction (HER) catalysts. Herein, an ultrafast self-heating synthesis delivers robust Mo₂C/MoC/CNT HER catalysts that can work at 1000 mA cm⁻² for 14 days.

The induction and regulation of axonal fusion after nerve injury remains poorly understood. Here authors show ferroptosis-induced lipid peroxidation enhances injury-triggered phosphatidylserine exposure to promote axonal fusion and enhanced functional restoration.

Morey and colleagues identify a dual function of CoREST in regulating sensitivity and resistance to endocrine therapies in breast cancer. This work also provides a pre-clinical model for study of the conversion of luminal/ER⁺ to basal/ER⁻ breast cancer.

Transition metal monochalcogenides have been predicted to host interesting superconducting and topological properties, but their synthesis remains challenging. Here, the authors report a self-intercalation method driven by ionic liquid gating to obtain PdTe and NiTe single crystals from PdTe₂ and NiTe₂, respectively.

2D materials are promising substrates for surface-enhanced Raman scattering (SERS)-based molecular sensing, but their performance is usually inferior to their plasmonic counterparts. Here, the authors report the synthesis of 1D/2D WO_3-x/WSe₂ heterostructures, showing high molecular sensitivity associated to ultrafast charge transfer timescales of ~1 ps.

Carbon dioxide influences plant–water relations and gas exchange by regulating stomatal aperture. Here, Tian et al. characterize RHC1, a MATE family transporter that under elevated carbon dioxide concentrations promotes stomatal closure via activation of the SLAC1 anion channel.

Single-cell RNA sequencing of haematopoietic cells from human embryos at different developmental stages sheds light on the development and specification of macrophages in different tissues.

2D semiconductors are attracting increasing attention as potentially scalable channels for future transistors, but the scaling of their contact length remains challenging. Here, the authors report the realization of 1D semimetal-2D semiconductor contacts based on individual carbon nanotubes with contact length down to 2 nm.

The CD47/SIRPα axis is well known to mediate immune escape by promoting cancer resistance to phagocytosis. Here the authors show that low CD47-expressing prostate cancer cells still allow phagocytosis but the process is incomplete leading to the formation of macrophage:tumor hybrid cells with immune evasive and pro-metastatic properties.

The authors design double shelled hollow superstructures from self-assembled CdSe/CdS nanorods in covalent organic frameworks for CO2 photo-reduction at a gas/solid interface.