Extended Data Fig. 4: Impact of changes in the attack rate on cases averted by IXCHIQ vaccination.
From: A framework for risk–benefit analysis of vaccines approved through accelerated pathways
Number of medically attended chikungunya cases or deaths averted per 10,000 vaccinated in each age group (colors). The dashed horizontal line indicates the threshold of zero net benefit. Negative values (shaded region) indicate net harm. Arrows indicate epidemiological scenarios used in the main analysis, from left to right: traveller, small outbreak, endemic transmission, large outbreak. Solid line represents mean estimates and shaded region represent 95% uncertainty intervals derived from n = 100,000 binomial samples. SAE: serious adverse event.
