Extended Data Fig. 5: Power to detect at least one death from vaccination.
From: A framework for risk–benefit analysis of vaccines approved through accelerated pathways
(a) Sample size needed to achieve 80% power to detect at least one death as a function of attack rate and probability of death from infection, assuming 95% vaccine efficacy. From left to right, the black arrows indicate the probability of death for CHIKV in the 18-64 age group (0.00005), SARS-CoV-2 (0.01), and EV (0.6). Sample sizes >20,000 are shown as 20,000. (b) Minimum population size required (vertical dashed line) for detecting that vaccine mortality risks do not exceed benefits with 80% power given a 5% attack rate (horizontal line), shown for the infection fatality rates (brackets) of CHIKV, SARS-CoV-2, and EV. CHIKV: Chikungunya virus. SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2. EV: Ebola virus. SAE: serious adverse event.
