Fig. 3: Association between the EastDiet and circulating metabolites.
From: Eastern coastal Chinese diet associated with reduced obesity and improved cardiometabolic health
a, The associations of the EastDiet and individual food groups with metabolites (n = 8,844). Multivariable-adjusted linear regression models were used to estimate β coefficients and P values for associations between dietary clusters and metabolites. The outer ring of the circular heat map displays β values for 96 metabolites significantly associated with the EastDiet (Bonferroni-adjusted P < 0.05, two-sided). Green bars indicate metabolites enriched in the EastDiet (β > 0), whereas yellow bars indicate lower levels (β < 0). Partial Spearman correlations were used to analyze associations between individual food groups and the 96 metabolites (BH-adjusted P < 0.05, two-sided). In the heat map, white indicates non-significant associations, red indicates significant positive correlations and grey indicates significant negative correlations. The colour intensity is determined by −log(BH-adjusted P) × direction. The innermost ring shows the superclass classification of each metabolite. b, An enrichment analysis of differential metabolites. Metabolite subclass annotations were obtained from the Human Metabolome Database, and subclasses containing at least two differentially abundant metabolites are shown. Green indicates enrichment in the EastDiet group.
