Fig. 5: Gut microbiota–metabolite interaction network and their associations with obesity and MACE in relation to the EastDiet.
From: Eastern coastal Chinese diet associated with reduced obesity and improved cardiometabolic health
a, The network displays partial Spearman correlations (|r| > 0.3, BH-adjusted P < 0.05, two-sided) between gut microbial genera and metabolites (n = 6,216). Microbial genera are shown as circles and metabolites as diamonds. All labelled nodes represent features significantly associated with the EastDiet, with green indicating positive associations and yellow indicating negative associations. Red edges indicate positive correlations, whereas blue edges indicate negative correlations. Darker colours and thicker lines represent stronger correlations and lower P-adjusted values, respectively. b, Associations of EastDiet-related microbial genera and metabolites with obesity-related indices (n = 6,209 for BMI, n = 6,207 for WC and waist-to-hip ratio, n = 6,204 for waist-to-height ratio and n = 6,156 for other DXA measurements). Partial Spearman correlations were used (BH-adjusted P < 0.05, two-sided). In the heat map, white indicates non-significant associations, red indicates significant positive correlations and grey indicates significant negative correlations. The colour intensity is determined by −log(BH-adjusted P) × direction. The innermost ring indicates metabolite superclass and microbial phylum classification. Green indicates genera enriched in the EastDiet group. c, Prospective associations of EastDiet-related biomarkers with incident MACE (n = 6,216). Multivariable-adjusted Cox proportional hazards models were used to estimate HRs and 95% CIs, with pattern 1 as the reference. Points represent HR estimates, and line segments represent 95% CIs. Only biomarkers significantly associated with MACE (two-sided P < 0.05) are shown.
