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In this study, we conduct meRIP-seq analysis on macrophages during their differentiation and activation to elucidate the landscape of the m6A spectrum across different stages. Combined analysis of RNA-seq and meRIP-seq revealed that Kdm6b interacts with and demethylates Jak1, promoting its phosphorylation-mediated activation of macrophages. Activated macrophages interact with T cells to promote atherosclerosis progression.
