Biochemistry and Cell Biology articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 1277

Article ‘Count’ for Biochemistry and Cell Biology.

Journal Count Share
9 6.75
Nanoscale Fluorescent Characterizations and Origin Tracing of Extracellular Vesicles through Standard Preparation Methods 1.00
Nicotinamide-Loaded Peptoid Nanotubes for Energy Regeneration in Acute Brain Injury 1.00
Noninvasive, Rapid, and Precise Identification of Esophageal Cancer via Salivary Extracellular Vesicle-Based Diagnosis 0.21
Nanopore Label-Free Monitoring of B-DNA and Z-DNA Conformational Transition in Real Time 1.00
Prototyping Minimal Extracellular Vesicle Mimetics Using Cell-Free Synthesis 1.00
Precise and Mechanical Control of Calcium Signaling in Muscle Cells by Near-Infrared-Activated Molecular Jackhammers 1.00
Random Heteropolymers Enable Nonspecific Protein Binding and Loop-Mediated Stabilization 1.00
Random Metastructures for Nanoscale Visualization of Single-Exosome Dynamics in a Gut–Brain-Axis-on-a-Chip 0.13
Engineering Liposomes with Cell Membrane Proteins to Disrupt Melanosome Transfer between Cells 0.42
4 2.81
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion 0.04
STRUCTURAL INSTABILITY OF THE SUPERFICIAL LAYERS OF THE FIBRINOGEN MATRIX CONTRIBUTES TO ITS NONADHESIVE PROPERTIES 1.00
Transient receptor potential vanilloid 4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm’s canal cells 0.78
Human induced pluripotent stem cell-derived nanovesicles for the treatment of ischemic limb disease 1.00
2 1.75
Dynamic Matrix Stiffening Reprograms Endothelial Angiogenic Remodeling via α2-Integrin Mechanotransduction 1.00
Shear‐Induced CROSS (Cellular RedOx Spreading Shield) Assembly Sustains Neurotrophic Extracellular Vesicle Production for Functional Neural Networks 0.75
3 0.98
Multiphysics‐Driven Assembly of Biomimetic Vesicles 0.06
Microneedle Delivery of Small Extracellular Vesicles From Young Blood to Treat Endothelial Senescence 0.83
Materials Evolution by Programmed Twisting: a DNA-Inspired Ultrastrong Supercoiled Conformational Fiber for Energy-Storage and Buffering 0.09
4 1.29
Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly 0.17
Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder 0.12
Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies 0.07
Cross-omics risk scores of inflammation markers are associated with all-cause mortality: The Canadian Longitudinal Study on Aging 0.93
2 1.34
The Pathogenic a Disintegrin and Metalloprotease with Thrombospondin Type I Motifs-2 D167N Variant Causes Geleophysic Dysplasia–Like Connective Tissue Changes in Mice 1.00
Loss of aquaporin-1 in tumor cells fosters intrahepatic cholangiocarcinoma progression 0.34
56 45.91
High-Resolution Ion Mobility-Based Isotopic Shifts of Dimethylated Peptide Isomers 1.00
Native Charge Detection Mass Spectrometry of Kilobase-Scale Messenger RNAs 1.00
Molecular Analysis of Single Tumor-Derived Extracellular Vesicles with Improved Robustness and Accuracy 0.88
Ion Mobility Suite (IMoS) 2: A General Computational Framework for Solving the Generalized Boltzmann Equation with Rotational Transport for Polyatomic Ions in Arbitrary Fields 1.00
Systematic Quantification of Protein O-GlcNAcylation Reveals Common and Cell-Type-Specific Responses to N-Glycosylation Inhibition in Human Cells 1.00
GDAS: A Machine Learning-Driven Approach for the High-Throughput Identification of Disease-Associated Glycoforms 0.15
A Unified Bayesian Framework for Cross-Technology Collision Cross Section Postcalibration Correction and Multilaboratory Harmonization 1.00
Anion Supercharging Enables Structural Analysis of Oxidatively Released O-Glycans 0.25
A Potassium Phosphoramidate-Based Strategy for Compiling and Profiling the Noncanonical N‑Phosphoproteome of Nasopharyngeal Carcinoma 0.11
Tandem-Trapped Ion Mobility Spectrometry as a Platform for Conformationally Resolved Analysis of Protein Complexes and Biologics 1.00
Polymerase κ Recruits DDX23 To Promote R-Loop Resolution 0.85
Impact of High Mannose Glyco Pairing on the Pharmacokinetics of a Therapeutic monoclonal antibody using an Immunocapture-LC/MS Intact Assay 0.57
Dose-Dependent Inhibition of Protein Glycosylation Reveals Crosstalk between Glycosylation and Phosphorylation in EGF Signaling Pathways 1.00
Optimized Low-Field Differential Ion Mobility Separations with High-Resolution Mass Spectrometry for Top-Down Proteomics 1.00
Interface-Sensitive Epi-Coherent Anti-Stokes Raman Scattering Microscopy for Imaging Cell Adhesion Dynamics 1.00
Streamlined Digital Microfluidics-Mass Spectrometry Strategy for Extracellular Vesicle Enrichment and Lipid Profiling 0.05
Quantifying Thiol Abundance and pKa Values in Natural Organic Mixtures Using HERFD-XANES Spectroscopy 0.33
Detection and Profiling of Neurodegenerative Disease-Related Extracellular Vesicles through Membrane and Cargo Proteins 1.00
Tandem Mobility Measurements of Ionic Liquid Cluster Volatilities 1.00
Investigating the Effect of Isoelectric Points on the Gas-Phase Stability of Native-like Proteins Analyzed in Positive- versus Negative-Ion Mode by IMS-MS 1.00
High-Resolution Ion Mobility Mass Spectrometry for Separation of Oligonucleotide Phosphorothioate Diastereomers 1.00
A Chemoenzymatic Method To Systematically Quantify Core Fucosylation Stoichiometry of Glycoproteins and Reveal Its Roles in EMT and Embryonic Development 1.00
GlypPRM: An Automated Analyzer and Quantification Tool for Glycopeptides Parallel Reaction Monitoring 1.00
Spatial Ion Compression without Loss of Resolution on a Cyclic Ion Mobility Spectrometry–Mass Spectrometry Platform 1.00
Characterization of Gas-Phase Native(-like) Proteins Using Structures for Lossless Ion Manipulations 1.00
Addressing the Determinants of Ambiguous Assignments Incurred by the Mass Spectrometry Sequence Analysis of Large Modified RNAs 1.00
Time-Resolved “Barbecue” Förster Resonance Energy Transfer for Sensitive and Homogenous Detection of Alginate 0.17
Dissecting Heterogeneous Populations of Protein-Complex Samples Using Direct Mass Technology 1.00
Accurate Mass Differences of High Molecular Weight Unknown Compounds from Resolved Isotopic Distributions: Oligonucleotide Impurities 1.00
Multistage Tandem Mass Spectrometry Using an Electron-Activated Dissociation Device with a Linear Ion Trap and Structural Identification of Cardiolipins 0.29
Solving the “General Elution Problem” of Ion Mobility Spectrometry: Single-Run Voltage Sweep 1.00
Complete Sequencing of a Hybrid Peptide/Peptide-Nucleic Acid Construct with MALDI-TOF/TOF Mass Spectrometry 1.00
Comprehensive Internal Standards for Hydrogen–Deuterium Exchange Mass Spectrometry 1.00
GlycoFASP: A Universal Method to Prepare Complex Mixtures for O-Glycoproteomic Analysis 1.00
Multiplexed Fiber-Optic Fluorescence for Functional Monitoring of Perfused Hearts 0.13
Macromolecular Separations by Ion Mobility Focusing in Divergent Asymmetric Electric Fields 1.00
Inverse Infrared Spectral Deconvolution for Quantitative Analysis of Polymer Mixtures in Scattering Media 1.00
Characterization of the Intact Proteomic Profile of Senescent-Associated Secretory Phenotype by Top-Down Mass Spectrometry 1.00
Comprehensive and Site-Specific Characterization of Protein N-Glycosylation in AD Samples Reveals Its Potential Roles in Protein Aggregation and Synaptic Dysfunction 1.00
Coupling Drift Tube Ion Mobility Measurements with Charge Detection Mass Spectrometry for the Analysis of Virus-like Particles and Other Megadalton-Sized Ions 1.00
Hydroxyl and Trifluoromethyl Radical Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides 1.00
A Biosensor Platform for Detecting the Dissipation of Transmembrane Gradients in Single Liposomes 1.00
Improved Mass Analysis of Proteins and Protein Complexes Present in Common Biological Buffers and Physiological Concentrations of NaCl Using Solution Additives Delivered by Theta Emitters 1.00
Paired Neural Network for Matching Experimental and Predicted Infrared Spectra 1.00
Broadband Fourier-Transform Optical Photothermal Infrared Spectroscopy and Imaging 0.86
Monitoring Molecular Uptake and Cancer Cells’ Response by Development of Quantitative Drug Derivative Probes for Chemical Imaging 1.00
Quantitative HILIC-Q-TOF-MS Analysis of Glycosaminoglycans and Non-reducing End Carbohydrate Biomarkers via Glycan Reductive Isotopic Labeling 0.97
Simple One-Step Deuterated Peracetylation-MALDI-MS/MS (OSDPM) Strategy for Structural Sequencing of Glycosaminoglycan Oligosaccharides 0.70
Compound-Specific and Intramolecular δsup15/supN Analysis of a Poly-Nitrogenous Amino Acid: Histidine 1.00
Proteome-Wide Identification of O6-Methyl-2’-deoxyguanosine-Binding Proteins 1.00
Unveiling the Accurate Site-Specific N- and O-Glycosylation of Hyperglycosylated Erythropoietin Drugs by an Integrated Approach 0.25
An Approach for Measuring Extracellular Vesicle Size Using the Attenuation-Velocity Change Ratio of SH-SAW Biosensors 0.06
Single Molecule Kinetic Fingerprinting of Glycans on IgA1 Antibodies 1.00
Histone Analysis Using Mobility- and Mass-Selected Ultraviolet Photodissociation in Tandem with Ultra-High-Resolution Mass Spectrometry 0.83
Enhancing Sensitivity in Low-Load Proteomics Orbitrap Workflows via SLIM Integration 0.46
Top-Down Characterization of Yeast tRNA by Gas-Phase Fractionation and Collisionally Activated Dissociation Informed by Electron Photodetachment Charge Reduction Mass Spectrometry 1.00
1 1.00
The Effects of Isoflurane Inhibition of Mitochondrial Complex I on Calcium Removal in Mouse Neuronal Cultures. 1.00
22 15.26
Minimal ATP-Independent N2-Reducing Systems Defined by L-Cluster-Bound Nitrogenase Assembly Platforms 1.00
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase 0.04
Structural Mechanism of an Efficacy Photoswitch Targeting the β2-adrenergic Receptor 0.18
Lysine Targeting Group-Transfer Chimeras for Proximity Induction 0.97
Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function 1.00
Biomimetic NaK Channel Membrane Enabled by a Crown Ether-Coordinated Metal–Organic Framework 0.13
Efficient Preparation of Homogenous Antibody Conjugates via Glycosite‐Specific Transglycosylation Enabled by Readily Available Glycosyl Donors 1.00
Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross-Protection 0.10
Aromatic Pentaamide Macrocycles as High-Affinity Sulfate Binders and Efficient Transporters 1.00
Investigation of Intercellular Trafficking of Global Glycosylphosphatidylinositol-Anchored Proteins Using Cell Metabolic Engineering and Transwell Coculture 1.00
Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System 0.63
Some Like It Hot –Structural Changes in Extremophile Rubredoxin at 120 °C 1.00
Chemoenzymatically Synthesized O-Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context 0.08
Acinetobacter baumannii α2–6-Legionaminyltransferase-Catalyzed Synthesis Reveals Legionaminic Acid Form Selectivity by Antibodies in Pooled Human IgGs 1.00
Rapaprotin, an Endopeptidase-Activated Proteasome Inhibitor that Induces 26S Disassembly 0.64
PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes 1.00
Mitochondria-Targeting Abasic Site-Reactive Probe (mTAP) Enables the Manipulation of Mitochondrial DNA Levels 1.00
Tuning Encodable Tetrazine Chemistry for Site‐Specific Protein Bioorthogonal Ligations 1.00
Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MS 1.00
Catch, Cut, or Block? Versatile 4-N-Derivatized Sialyl Glycosides for Influenza Virus Neuraminidase Detection and Purification 1.00
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2-Adrenoceptor 0.20
A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage 0.29
1 0.25
Pathogenic Variants in RNU2-2, a Non-coding Spliceosomal RNA, Cause a Distinctive Developmental and Epileptic Encephalopathy 0.25
1 0.90
Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury 0.90
2 0.98
Proteasome subunit PSMD1 is a key therapeutic target in multiple myeloma 0.95
Post-transcriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML 0.04
1 0.18
Functional expression of the T-type Cav3.2 calcium channel in female and male human dorsal root ganglion neurons 0.18
2 1.77
Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity 0.88
Lymphoma accelerates T cell and tissue aging 0.88
5 3.84
Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors 0.83
Lipid Composition Alters Ferroptosis Sensitivity 1.00
BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells 0.04
XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance. 0.96
Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis 1.00
21 19.21
Galvanin (TMEM154) is an electric-field sensor for directed cell migration 1.00
Nuclear envelope budding enables export of large transcripts in muscle cells 1.00
Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles 1.00
Mitochondrial control of glycerolipid synthesis by a PEP shuttle 1.00
Bringing the genetically minimal cell to life on a computer in 4D 0.94
Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease 1.00
Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux 1.00
A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis 1.00
Continuum architecture dynamics of vesicle tethering in exocytosis 0.06
The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism 1.00
Membrane potential mediates the cellular response to mechanical pressure 0.76
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis 0.94
Molecular grammars of predicted intrinsically disordered regions that span the human proteome 1.00
Disparate leukemia mutations converge on nuclear phase-separated condensates 0.84
Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens 1.00
Mitochondrial activity tunes nociceptor resilience to excitotoxicity 1.00
RNA Pol II inhibition activates cell death independently from the loss of transcription 1.00
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming 1.00
Principles of cotranslational mitochondrial protein import 0.67
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling 1.00
Optogenetics-enabled discovery of integrated stress response modulators 1.00
1 0.05
Exploring functional insights into the human gut microbiome via the structural proteome 0.05
6 5.02
Muscle-derived Mimecan regulates hypothalamus-brown adipose tissue communication and promotes health and lifespan in mice 1.00
Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts 1.00
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function 0.19
A metabolic atlas of mouse aging 0.85
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice 0.99
Aged mice exhibit widespread metabolic changes but preserved major fluxes 1.00
3 2.59
Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems 0.79
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells 0.80
Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat 1.00
5 3.40
Peptide–protein docking: from physics-based models to generative intelligence 0.80
Inhibition of glycoprotein biosynthesis in the pathogenic bacterium Helicobacter pylori by masked carbohydrate phosphonates 0.43
Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain 1.00
Triplex formation-mediated fluorescence sensing of single bulge nucleotide-containing double-stranded RNAs using thiazole orange base surrogate-carrying PNAs 0.25
Historical account of dinitrogen-bridged diiron complex synthesis using a commercial tripodal ligand 0.92
11 8.94
Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR 1.00
Molecular jackhammers induce intracellular calcium release and skeletal muscle contraction by vibronic-driven action 1.00
Lan enzyme-free construction of lanthionine-bridged macrocyclic phage libraries 1.00
Kinetics overcome thermodynamics in primitive analogs of the reverse tricarboxylic acid cycle 1.00
Hangman dipyrrin complexes 1.00
Proton transfer during reduction of the catalytic metallo-cofactors of the three nitrogenase isozymes 1.00
De novo designed 3-helix bundle peptides and proteins with controlled topology and stability 0.06
The influence of protein electrostatics on potential inversion in flavoproteins 1.00
Wavelength dependent photochemistry of an iron dinitrogen hydride complex ivia/i multiple spectroscopies – competing ejection of axial ligands 0.83
Double crossed? Structural and computational studies of an unusually crosslinked haem in iMethylococcus capsulatus/i cytochrome P460 0.05
Precision dendritic-supramolecular glycan assemblies for probing multivalent lectin interactions 1.00
3 3.00
Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. 1.00
Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. 1.00
Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling. 1.00
16 11.34
Specialized high-capacity mitochondria fuel cell invasion 1.00
Polarized SOS activity orchestrates FGF-directed cell migration in vivo 1.00
Evolutionary tuning of an auditory transduction channel 1.00
Big1 is a cell-cycle regulator linking cell size to basal body number in Tetrahymena thermophila 1.00
Myosin II-driven contractions of supporting cap cells promote sensory adaptation of Drosophila proprioceptors 0.39
Regulation of mitophagy by Fis1 and Fascin1-organized actin 1.00
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration 0.17
The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast 1.00
Spef1 is a microvillar component that limits apical actomyosin contractility and preserves intestinal barrier function 1.00
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage 1.00
Metabolic rewiring prevents neurodegeneration caused by chronic mitochondrial dysfunction 1.00
The DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement 0.25
Mitochondrial function regulates cell growth kinetics to maintain mitochondrial homeostasis 0.20
Store-independent activation of STIM1-ORAI1 by SPCA2 determines the basal CFTR activity in secretory epithelial cells 0.05
The nuclear-cytoplasmic ratio controls the cell-cycle period in compartmentalized frog egg extract 0.29
Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release 1.00
4 3.06
Desmosomes compartmentalize mRNA and translation in the skin 1.00
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging 0.06
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm 1.00
On-demand delivery of fibulin-1 protects the basement membrane during cyclic stretching in C. elegans 1.00
1 1.00
Extracellular vesicle proteomic expression is influenced by mining tenure in former uranium miners 1.00
1 1.00
Assessing AlphaFold 3 for Per- and Polyfluoroalkyl Substances Docking in Protein Structures 1.00
1 0.92
Long noncoding RNA SALTe1, microvascular ageing, and cardiac dysfunction 0.92
5 4.41
tRNA synthetase activity is required for stress granule and P-body assembly 1.00
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe 1.00
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex 1.00
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3 0.70
UPR deficiency leads to poor growth, aneuploidy, and a trade-off between ER and general proteostasis in yeast 0.71
4 3.40
Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease 1.00
Genome-wide maps of CPD deamination in yeast reveal the impact of DNA sequence context and nucleosome architecture on cytosine deamination rates 1.00
Polycomb misregulation in enterocytes drives tissue decline in the aging Drosophila intestine 1.00
Widespread specific intron retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts 0.40
1 0.07
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL 0.07
1 1.00
Aging disrupts hepatocyte zonation homeostasis in mice and humans. 1.00
1 0.33
Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women 0.33
5 4.75
Aged circulating CD8+ T cells and their secreted factors drive cognitive decline 1.00
Pharmacologic glycoengineering of Fcγ receptor IIIa enhances force-resistant IgG-FcγR interactions and anti-tumor antibody efficacy 0.75
Human anti-glycan reactivity emerges from B cells utilizing private gene rearrangements that are affinity maturated in germinal centers 1.00
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer 1.00
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing 1.00
4 3.80
Disaccharide-Presenting Iron(II) Complexes as Synthetic Mimics of Natural Glycan Epitopes for Lectin Recognition 1.00
EPR and 31P ENDOR Characterization of Pseudo-Jahn–Teller Dynamics and N2 Activation in Functional Nitrogenase Models, P3EM(N2) (M = Fe, Co; E = Si, B, C) 0.80
Nitrogen Oxyanion Reductive Borylation at Low-Coordinate Iron: A Struggle between Two Oxophiles 1.00
Disabling the Entatic Control of Methionine Ligation through Additive Destabilization of Ferric Cytochrome 1.00
1 0.17
The effect of obesity and aging on NAD/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI 0.17
124 105.12
Cytosolic Heat Shock Protein 90 is Required for Photoreceptor Outer Segment Development and Vision 1.00
Kinetic Model of Partial Agonism Reveals Cellular Basis of Ligand Efficacy 1.00
Acid-sensing ion channel 2a assembles with epithelial Na+ channel β and γ subunits to form mechanosensitive ion channels 1.00
Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling 1.00
Systematic mapping of O-GlcNAc transferase and O-GlcNAcase defines disease-associated variants 0.67
NS5 polymerase stimulates RNA duplex unwinding by the Orthoflavivirus NS3 helicase 1.00
Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton 0.50
Structural Basis for HIV-1 Rev Recognition by the Histone Chaperone Human Nap1 1.00
Lipid Transfer Proteins and PI4KIIα Generate a Phosphoinositide-Linked Proteome 1.00
A direct, real-time, spectrophotometric assay for measuring ENPP1-catalyzed cGAMP hydrolysis 1.00
Domain-specific functions of LRIT3 in synaptic assembly and retinal signal transmission 1.00
Structure-guided Discovery of Non-catechol Dopamine D1 Receptor Ligands with Biased Agonism and Antagonism 1.00
A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks 1.00
Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry 1.00
Deletion of Mitochondrial Calcium Uniporter Enhances Calcium Signals by Slowing Calcium Clearance and Triggers Adaptive Transcriptomic Remodeling 1.00
Electrostatic tuning of the pyridoxal-5′-phosphate cofactor site defines pH dependence in type I cystathionine β-lyases 0.04
Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase 1.00
Structural basis of phosphodiesterase-5 conformational organization revealed by a PDE6/PDE5 Chimera 1.00
The Pof1 nicotinamide mononucleotide adenylyl transferase has a non-canonical role in NAD+ metabolism in the budding yeast Saccharomyces cerevisiae 1.00
G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model 1.00
SARS-CoV-2 envelope protein mitochondrial localization reveals host metabolic disruption 1.00
Fidelity of DNA ligase I is sensitive to physiological Mg2+ level 1.00
Transport of sphingolipids by yeast Npc2 supports phase separation of the vacuole membrane 1.00
ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma 1.00
Collagen IV of basement membrane: V. Bromide-mediated sulfilimine bonds interlock the quaternary structure of NC1-hexamer of scaffolds enabling metazoan evolution 1.00
Structure-Based Discovery of Selective Vaccinia-Related Kinase 1 Inhibitors and Fluorogenic Active-Site Probes 0.56
PA14 domain of glycosyltransferase B4GALNT3 is a lectin that binds to sulfated glycan ligands 0.22
Elevated neuraminidase potentiates lung inflammation through facilitating integrin β2-mediated adhesion and immune responses of neutrophils 1.00
Functions of prolyl hydroxylation in elastin 0.67
Deletion of Core 1 β3GalT-specific Molecular Chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis 1.00
G Protein Gαq Subunits Engage Targets in the Nucleus Involved in Chromatin Remodeling and Gene Expression 1.00
Identification of a distinct family of polyphosphate kinases relevant to energy homeostasis in Crenarchaeota 0.27
HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells 0.33
An evolutionarily conserved salt bridge stabilizes the active site for GTP hydrolysis in Rho GTPases 1.00
GPCR-selective effects of endocytosis on cellular signaling through the cAMP/PKA cascade 1.00
Profiling the Pancreatic Cancer Secretome with Metabolic Glycoengineering 1.00
Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice 0.95
The protease Cathepsin K can debulk the cancer glycocalyx 1.00
The terminal heme synthetic enzyme, Coproheme Decarboxylase, negatively regulates heme uptake in Mycobacterium tuberculosis 1.00
Target validation uncouples mitochondrial translocator protein from 19-Atriol-mediated inhibition of steroidogenesis and identifies enzymatic targets 1.00
Large extracellular vesicles regulate endothelial angiogenic potential via paracrine and autocrine signaling 1.00
Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5 1.00
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation 0.95
Matriptase-2-mediated suppression of hepatic hepcidin expression in mice requires hepatocyte neogenin 1.00
A GluN2B disease-associated variant promotes the degradation of NMDA receptors via autophagy 1.00
S-Nitrosylation of the Scaffold Protein STRAP Enhances Oxidative Stress–Induced Apoptosis 1.00
Clostridioides difficile TcdB induces expression of its receptor (CSPG4) through a noncanonical Hippo signaling mechanism 1.00
Enzymatic basis of branching and extension of O-Man glycans for keratan sulfate biosynthesis 0.25
A high throughput screen for nucleolar function reveals a role for the signaling protein, SPRR3, in ribosome biogenesis 1.00
A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding 1.00
Angiotensin receptor conformations stabilized by biased ligands differentially modulate β-arrestin interactions 0.40
GRK phosphorylation drives β-arrestin–independent internalization of chemokine receptor CXCR5 0.57
CDC123 is an ATPase that modulates mRNA translation and the Integrated Stress Response by regulating eIF2 complex assembly 1.00
A reversible feedback mechanism regulating mitochondrial heme synthesis 1.00
N-linked glycosylation plays an essential role in the stability and function of tissue-nonspecific alkaline phosphatase 0.22
Direct Optical Activation of Human IRE1 Identifies Unique Patterns of Transcriptional and Post-Transcriptional mRNA Regulation in the Unfolded Protein Response 1.00
Protein Kinase A regulates Cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP 1.00
Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes 0.95
Two calmodulin binding elements contribute distinctly to TRPA1 calcium desensitization 1.00
Oligomerization is Required for Channel Formation of MctB and for Copper Resistance of Mycobacterium tuberculosis 0.75
Cooperative ligand binding in a bacterial heme-based oxygen sensor 1.00
Inhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis 1.00
Rac1 Selectively Binds a Specific Lamellipodin Isoform via a Noncanonical Helical Interface 1.00
Three mammalian VDAC isoforms distinctly regulate mitochondrial function and proteome to maintain cell metabolism 1.00
Gene expression analysis and proximity labeling reveal post-transcriptional functions of the yeast RNA polymerase II regulator Def1 1.00
Binding of the brain G protein G⍺o to its potential effector RASA3 is promoted by Ca2+ 1.00
Phosphorylation at S1288 of Leukemia Associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA 0.75
Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics 1.00
A S180F substitution in D-alanine aminotransferase confers resistance to β-chloro-D-alanine in Staphylococcus aureus 0.57
The scaffold protein IQGAP1 regulates the epithelial Na+ channel 1.00
Rewiring PTH Receptor Signaling: Hormone Dimerization Restores Endosomal Signaling Lost in Hypocalcemia-Linked PTH Mutant 1.00
Biochemical characterization of the full-length isoform of soluble adenylyl cyclase 1.00
The Pseudomonas aeruginosa Membrane Histidine Kinase BqsS/CarS Directly Senses Environmental Ferrous Iron (Fe2+) 1.00
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA 0.36
Sertad1 is elevated and plays a necessary role in neuron loss and cognitive impairment in a mouse model of Alzheimer’s disease 0.20
Endophilin–lamellipodin–VASP, key components in fast endophilin–mediated endocytosis, control actin polymerization within liquid-like condensates 0.78
Decoding ultrasensitive self-assembly of the calcium-regulated Tetrahymena cytoskeletal protein Tcb2 using optical actuation 1.00
Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress 0.83
Simultaneous ligand binding to intact and partially formed ATP binding sites in the hexameric termination factor Rho 1.00
Transmembrane domain interactions underlie NSG1 regulation of sortilin ectodomain shedding 0.13
SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase 0.50
Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding 0.08
Systematic analysis of the RGS2 degron reveals characteristics of substrate recognition by the F-box protein FBXO44 1.00
Protein inhibitor of retinal membrane guanylyl cyclase suppresses cGMP synthesis in photoreceptors 1.00
The cytoplasmic domains of the CNNM family of transmembrane proteins modulate the ion channel-kinase TRPM7 0.85
Asymmetric coevolution of the MEK–ERK binding interface 1.00
TOR signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating pathway 1.00
WNT7A/B assemble a GPR124-RECK-LRP5/6 coreceptor complex to activate β-catenin signaling in brain endothelial cells 0.17
Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease 1.00
Get4/5-mediated remodeling of Get3's substrate-binding chamber: Insights into tail-anchored protein targeting by the GET pathway 1.00
A comparative analysis reveals electrogenic properties of PfCRT and pendrin 1.00
Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14 0.75
Insight into the high-potential branch of the alternate NAD+-dependent NADPH:ferredoxin oxidoreductase II (NfnII) from Pyrococcus furiosus: evidence for the gating step in electron bifurcation 0.67
The SNARE protein Ykt6 drives insertion of the GluA1 and GluA2 glutamate receptors at synaptic spines during long-term potentiation 1.00
Degradation of CaMKII is stimulated by its active conformation 1.00
Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations 1.00
In-depth analysis of the tear fluid glycoproteome reveals diverse lacritin glycosylation and spliceoforms 0.75
Catalytic region mimetics in Na+/H+ exchanger regulatory factor 4 suppress guanylate cyclase 2C activity to regulate enterotoxin triggered diarrhea 1.00
Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy 1.00
Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation 0.14
Proximity-Dependent Proteomics and Network Analysis of Adenylyl Cyclase Isoforms 5, 6, and 9 in Cardiomyocytes 0.75
Visualization of Covalent Intermediates and Conformational States of Proline Utilization A by X-ray Crystallography and Molecular Dynamics Simulations 1.00
Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex 0.80
Repeated activation of Gαq has a detrimental impact on C. elegans in an age-dependent manner 1.00
Two stages of substrate discrimination dictate selectivity in the Escherichia coli MetNI-Q ABC transporter system 1.00
Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression 1.00
GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants 1.00
Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum 0.91
ARRDC3 tyrosine phosphorylation functions as a switch to control c-Src versus WWP2 interactions and distinct scaffolding functions 1.00
Map of the Neuronal O-glycoproteome Reveal Driver Functions in the Regulated Secretory Pathway 0.19
Structural insights into the catalytic cycle of G protein–coupled receptor kinase 5 and a possible regulatory site for potassium ion 1.00
GAPDH heme delivery to Indoleamine 2,3-dioxygenase 1 involves complex formation and complementary charge pairing at their protein-protein interface 1.00
Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis 0.80
Translation-independent association of mRNAs that encode protomers of the 5-HT2A-mGlu2 receptor complex 1.00
Loss of integrin alpha7-mediated signaling induces a dendritic cell-like phenotype in macrophages cultured on laminin-211/221 isoforms 0.07
The Poly(A) Polymerase Star-PAP is Regulated by Stably Associated Phosphoinositide Messengers 0.88
Single-subunit RNA polymerases, KpnP, Ro45Iw, and CD23823, with precise terminal synthesis 0.20
Humanin variants aggregate to produce different fibril morphologies 1.00
Characterizing the excision of 7,8-dihydro-8-oxoadenine by thymine DNA glycosylase 1.00
Molecular basis for Gβγ-SNARE mediated inhibition of synaptic vesicle fusion. 0.96
Targeted incorporation of collagen IV to the basement membrane: a step forward for developing extracellular protein therapies 1.00
CH−π interactions confer orientational flexibility in protein–carbohydrate binding sites 1.00
Ancestral evolution of oxidase activity in a class of (S)-nicotine and (S)-6-hydroxynicotine-degrading flavoenzymes 1.00
Identification and characterization of mono- and bifunctional galactan synthases in the pediatric pathogen Kingella kingae 0.75
43 34.02
Hoi1 targets BLTP2 to ER–PM contact sites to regulate lipid homeostasis 0.22
Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy 1.00
Mitochondrial presequences harbor variable strengths to maintain organellar function 0.80
Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1 0.96
Cdc5-mediated Ulp2 phosphorylation controls the timing of polySUMOylation during the cell cycle 1.00
GRIPAP1 is an endosomal tethering factor mediating platelet α-granule biogenesis 1.00
RCC1 depletion drives protein transport defects and rupture in micronuclei 1.00
Two δ-catenins, plakophilin 4 and p120, promote formation of distinct types of adherens junctions 1.00
Potassium ion homeostasis modulates mitochondrial function 1.00
Mechanometabolism of cell adhesion: Vinculin regulates bioenergetics via RhoA-ROCK 1.00
Atypical E-cadherin attachments mediate melanoblast migration through confined epithelial spaces 0.86
Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis 0.83
p62 sorts Lupus La and selected microRNAs into breast cancer-derived exosomes 1.00
Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway 0.06
Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion 0.78
TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification 1.00
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation 0.27
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM 1.00
Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion 1.00
Aip5 forms a “composite” actin nucleator with Bud6 and caps pointed ends of actin filaments 1.00
Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes 1.00
A key role of Canoe’s intrinsically disordered region in linking cell junctions to the cytoskeleton 1.00
Bni5 regulates and coordinates septin architecture and myosin-II functions at the cell division site 1.00
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors 0.19
JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation 1.00
PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity 1.00
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex 0.89
ATG conjugation–dependent/independent mechanisms underlie lysosomal stress–induced TFEB regulation 0.05
The yeast Mkt1/Pbp1 complex promotes adaptive responses to respiratory growth 1.00
ATG16L1 controls mammalian vacuolar proton ATPase 0.92
WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation 0.63
Visualizing nuclear pore complex plasticity with pan-expansion microscopy 1.00
Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation 0.88
Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity 0.91
The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria 0.13
A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion 0.33
Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport 1.00
Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair 1.00
A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome 1.00
A collagen IV fluorophore knock-in toolkit reveals trimer diversity in iC. elegans/i basement membranes 0.63
An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate 0.53
The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks 1.00
Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2 0.17
14 13.23
Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor renewal in idiopathic pulmonary fibrosis 1.00
THEMIS attenuates MASH by suppressing disease-associated hepatocyte induction and hepatocyte senescence in mice 1.00
Hepatic glutathione depletion ameliorates MASLD through selective protein oxidation and inhibition of lipogenesis 0.89
Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease 0.98
AAV-mediated gene therapy in a SLC13A5 citrate transporter disorder model rescues epileptic and metabolic phenotypes 1.00
Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes 1.00
JNK3 regulates β cell responses to incretins in human islets and mouse models 0.91
Nitric oxide required for transition to slower hepatic protein synthesis rates during long-term caloric restriction 1.00
Genetic disruption of mitochondrial dynamics and stasis leads to liver injury and tumorigenesis 1.00
ER stress sensor PERK promotes T-cell pathogenicity in GVHD by regulating ER-associated degradation 1.00
Plasminogen Activator Inhibitor-1 promotes aortic aging-like pathophysiology in humans and mice 0.94
Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase 0.79
Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques 1.00
Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms 0.73
4 3.68
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis 0.83
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine 1.00
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2 0.97
Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss 0.88
5 4.63
Distinct Roles of CaMKII in Synaptic Vesicle Dynamics at Zebrafish Retinal Rod Bipolar Ribbon Synapses 0.91
Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity 1.00
High-pressure freezing EM tomography of entire ribbon synapses in the retina 0.72
Active zone maturation controls presynaptic output and release mode and is regulated by neuronal activity 1.00
Hearing loss and audiogenic seizures induced by hypofunctional prestin variants 1.00
16 11.29
Erg currents support electrical bursting in murine anterior pituitary corticotrophs 0.17
Ephaptic coupling and the source–sink effect of cardiac conduction 1.00
Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics 1.00
Age‐related decline in NCKX4‐mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing 1.00
Dynamic balance of myoplasmic energetics, redox state and protons in a fast‐twitch oxidative glycolytic skeletal muscle fibre 0.20
Two distinct mechanisms for GlyH‐101 block of the CFTR chloride channel 0.30
Mechanism of CO2 and NH3 transport through human aquaporin 1: Evidence for parallel CO2 pathways 0.90
Interplay of Ca2+ and PIP2 in TMEM16A channel function 1.00
Electrodiffusion in cardiac intercalated disc nanostructures alters cell–cell action potential transmission via ephaptic coupling: A model study 0.40
Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in male mice 1.00
Deletion of the TRPV1 channel attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure 1.00
Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia 0.15
The Christianson syndrome protein, sodium hydrogen exchanger isoform 6, is required for fat accumulation 1.00
GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition 0.92
A simple voltage‐modulated Markov chain model for the Piezo1 ion channel to investigate electromechanical pacing 0.25
Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq 1.00
55 43.01
De Novo Design of Miniature and Efficient Metallo-Ketoreductases 0.29
Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation 0.38
A Synthetic Iron Model of Carbon–Sulfur Bond Activation by the Nitrogenase-Family Enzyme Methylthio-Alkane Reductase 1.00
Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists 0.71
Non-Enzymatic MGO-Glycation of SRSF2 Drives RNA Mis-Splicing 0.78
The Factors Governing Metal Dependence of an Emergent Superfamily of Bimetallic Oxygenases 1.00
Sulfite Is Not Required for N2 Reduction Catalyzed by Mo-Nitrogenase 0.83
Turning Up the Heat: Wireless Induction Heating for Multitemperature Microscale Reactions 1.00
Expanding the Genetic Code with Lysine Aminoacylation 1.00
Chemoenzymatic Synthesis of N-Linked Glycan Receptors of H1N1 Influenza Virus on Human Airway Epithelial Cells 0.80
An Automation Platform for the Chemoenzymatic Synthesis of Complex Sulfated and Branched Glycans 0.92
Ribosomal Translation and Display Selection of Cyclic Glycopeptides through Genetic Reprogramming 0.03
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome 1.00
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases 1.00
Computational Design of a Highly Stable Dicopper Catechol Oxidase 1.00
Endogenous Site-Specific Encoding of Trifluoromethyl-Bearing Phenylalanine and Tryptophan for in-Cell 19F NMR 0.71
Correlating Protein Dynamics and Catalytic Activity of a Model Hydrogenase Using Paramagnetic and Biological Nuclear Magnetic Resonance Spectroscopy 1.00
Phosphoglycerate Kinase Can Adopt Topologically Misfolded Forms That Are More Stable Than Its Native State 1.00
Mapping GlycoRNAs on an Exosomal Surface 1.00
The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling 0.70
Conserved Transmembrane Asparagine Is Essential for the Ion-Conducting Structure and Dynamics of the SARS-CoV-2 Envelope Protein 1.00
Covalent Drug Binding in Live Cells Monitored by Mid-Infrared Quantum Cascade Laser Spectroscopy: Photoactive Yellow Protein as a Model System 0.88
Determination of Thermochemical Barriers in Multiple-Collision-Induced Dissociation Experiments on Gas-Phase Protein Complexes 1.00
N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptor 1.00
Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs 0.75
De Novo Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders 0.29
Methyl-Containing Iron–Sulfur Cluster with FeMoco Geometry 0.50
Disruption of β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction Using Heterogeneous Peptidomimetic Foldamers 0.20
Kupyaphores─Self-Assembling Diisocyanolipopeptide ZnII Ionophores in Mycobacterium tuberculosis ZnII/CuI/II Homeostasis and Antibacterial Effects 0.62
De Novo Design, Directed Evolution and Computational Study of Heme-Binding Helical Bundle Protein Catalysts for Biocatalytic Enantioselective Ge–H Insertion 1.00
Conversion of a Heme-Dependent Dehydratase to a Piperazate Synthase Reveals the Role of the Heme Propionate Group in N–N Bond-Formation 0.08
Advancing Chemoenzymatic Synthesis and Covalent Immobilization of a Comprehensive Ganglio-glycosphingolipid Library Enables Functional Multiplex Bead Assays 1.00
Chemoenzymatic Synthesis of Asymmetric Bisecting Bi-, Tri-, and Tetra-Antennary N-Glycans 0.93
Enzyme-Activated Sugar-Coated Bifunctional Degraders 0.67
Quantification of Membrane Protein Conformational Free Energy from Mutations and a Single Atom 1.00
Biosynthesis of Unnatural Cyclodipeptides through Genetic Code Expansion and Cyclodipeptide Synthase Evolution 1.00
Cyclization Decoded: Engineering Amylomaltase for Efficient α-Glucan Transformations 0.04
Molecular Basis for the Activation of Pseudomonas aeruginosa MsbA by Divalent Metals 1.00
Late-Stage Serine Modification Enables Noncanonical Peptide Synthesis 1.00
Periodic Trends in M–Fe Interactions across an Isostructural and Isoelectronic Series of [MFesub3/subSsub4/sub] Clusters (M = V, Cr, Mo, W) 1.00
Distinct Electric Fields Enable Common Catalytic Function in Structurally Diverse Enzymes 1.00
Photochemistry of Sulfur Dioxide Mediated by Charge Transfer through Intermolecular Chalcogen Bonds 0.20
Examination of a Chimeric Bis-Electrophile for Selective DNA–Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity 1.00
Proteomic Tracking Extracellular Vesicle RNA Interactors in Recipient Immune Cells through Orthogonal Labelings 1.00
Radical-Initiated Photodissociation at Tryptophan Residues within Intact Proteins in the Gas Phase 1.00
Ultrahigh-Throughput Multiplexed Screening of Purified Protein from Cell-Free Expression Using Droplet Microfluidics 0.90
Distal Mutations in a Designed Retro-Aldolase Alter Loop Dynamics to Shift and Accelerate the Rate-Limiting Step 0.22
Modulating the Binding Kinetics of Bruton’s Tyrosine Kinase Inhibitors through Transition-State Effects 0.75
Design and Synthesis of Hetero-Bicephalic Detergents for Native Mass Spectrometry of Membrane Proteins 1.00
Roles of Three Conserved Active Site Residues of Cytochrome c Nitrite Reductases During the Early Steps of Nitrite Reduction 1.00
Chemoenzymatic Synthesis of Glycosphingolipids Having an HNK-1 Epitope for Erythrocyte Cell Surface Remodeling 0.58
Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a “Snap-through” Instability 0.55
Rational Design of a Foldon-Derived Heterotrimer Guided by Quantitative Native Mass Spectrometry 1.00
A Fast Neural Network for Isotopic Charge State Assignment 1.00
A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases 0.71
1 0.97
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women 0.97
1 0.09
Mechanisms of Podocyte Injury Due to Loss of the Nucleoporin NUP93. 0.09
1 1.00
Proteomic aging clocks and the risk of mortality among long-term cancer survivors 1.00
3 1.11
Mitochondrial respiratory capacity in kidney podocytes is high, age-dependent, and sexually dimorphic. 1.00
Absence of glomerular IgA1 deposition despite overexpression of galactose-deficient IgA1 in the B cell c1galt1 knockout mouse 0.07
UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis 0.04
2 1.25
Energy Landscape and Stability in Random Heteropolymers: Somewhere Between Protein Folding and Plastic Miscibility 1.00
Facile and Controlled Synthesis of Poly(ethylene glycol)-Polypeptide in an Acidic, Biphasic System 0.25
21 15.76
Mitochondria-lysosome coupling contributes to lysosome acidification and aging 1.00
Design principles of a membrane-spanning ubiquitin ligase 0.60
Ribo-Tweezer: Rapid removal of ribosomal proteins reveals additional layers of post-transcriptional gene regulation 0.97
The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps 1.00
Mitochondrial translation elongation controls OXPHOS biogenesis by coordinating synthesis and folding of mitochondrially encoded proteins 0.29
BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes 0.94
Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression 0.24
Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription 1.00
Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen 1.00
Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway 0.86
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis 1.00
Tuning insulin receptor signaling using de novo-designed agonists 1.00
KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1 0.21
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition 1.00
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress 0.13
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria 1.00
TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling 1.00
Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 0.85
SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging 0.57
The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress 0.10
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma 1.00
4 2.95
Pyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease models 0.89
Ganglioside sialylation modulates tau internalization and pathology spread 0.05
A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins 1.00
PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD 1.00
4 1.80
Polymerized Short Sequences as a Template for Protein Folding and Evolution 1.00
Urinary Exosome Isolation and Enrichment as Enabling Liquid Biopsy by Biologically Intact Exosome Separation Technology: BEST 0.30
Anomalous Ion Transport in 2D Graphene Oxide Nanochannels Enabled by Hydration Mimicry with Confined Amino Acids 0.43
T-Cell-Derived Extracellular Vesicles with an Antitransferrin Receptor Antibody for Multicancer Targeting 0.07
46 32.09
Universal transcriptomic hallmarks of mammalian ageing and mortality 0.54
β-Arrestin condensates regulate G-protein-coupled receptor function 0.62
Human haematopoietic stem cells remember inflammatory stress 0.24
De novo design of miniproteins targeting GPCRs 0.47
Long-term editing of brain circuits using an engineered electrical synapse 1.00
SNOR promotes translation restart after dormancy 0.80
Glycerol-driven TNAP activation in thermogenesis and mineralization 0.16
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis 0.95
Dynamics of genetic and somatic trade-offs in ageing and mortality 0.74
Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair 0.86
Structural energetics of cold sensitivity 1.00
Thymic health consequences in adults 0.64
The dynamic basis of G-protein recognition and activation by a GPCR 0.05
Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity 1.00
The molecular basis of force selectivity by PIEZO2 1.00
Accurate predictions of disordered protein ensembles with STARLING 1.00
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome 0.79
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling 0.85
Robust cytoplasmic partitioning by solving a cytoskeletal instability 0.25
LetA defines a structurally distinct transporter family 0.89
Disease tolerance and infection pathogenesis age-related tradeoffs in mice 1.00
Polyamine-dependent metabolic shielding regulates alternative splicing 0.06
-Methylpseudouridine directly modulates translation dynamics 0.14
Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor 1.00
GTP release-selective agonists prolong opioid analgesic efficacy 1.00
Transient hepatic reconstitution of trophic factors enhances aged immunity 1.00
Computational design of metallohydrolases 0.94
Hepatic zonation determines tumorigenic potential of mutant β-catenin 0.12
ZAK activation at the collided ribosome 0.45
Structural basis of regulated N-glycosylation at the secretory translocon 1.00
Structural snapshots capture nucleotide release at the μ-opioid receptor 1.00
Helicase-mediated mechanism of SSU processome maturation and disassembly 1.00
Mechanism of conductance control and neurosteroid binding in NMDA receptors 1.00
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion 1.00
Designing allosteric modulators to change GPCR G protein subtype selectivity 0.93
Bottom-up design of Ca2+ channels from defined selectivity filter geometry 1.00
Enzyme specificity prediction using cross attention graph neural networks 1.00
Design of facilitated dissociation enables timing of cytokine signalling 0.89
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis 0.95
Structure and mechanism of the mitochondrial calcium transporter NCLX 1.00
One-shot design of functional protein binders with BindCraft 0.31
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis 0.90
The role of metabolism in shaping enzyme structures over 400 million years 0.13
Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors 0.05
Complete computational design of high-efficiency Kemp elimination enzymes 0.17
NINJ1 regulates plasma membrane fragility under mechanical strain 0.20
6 3.30
Artificial allosteric protein switches with machine-learning-designed receptors 0.30
Antibody-lectin chimeras for glyco-immune checkpoint blockade 0.81
Democratizing protein language model training, sharing and collaboration 0.18
A trimodal protein language model enables advanced protein searches 0.08
Target sequence-conditioned design of peptide binders using masked language modeling 0.92
Topological velocity inference from spatial transcriptomic data 1.00
17 11.15
Stress granules restrain ferroptosis by sequestering ferritin 0.03
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells 0.33
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress 0.91
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis 0.88
Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy 0.07
DNA nanodevices detect an acidic nanolayer on the lysosomal surface 0.02
Programmed mitophagy at the oocyte-to-zygote transition promotes lineage endurance 1.00
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction 1.00
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier 0.40
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death 0.27
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis 1.00
CHIP protects lysosomes from CLN4 mutant-induced membrane damage 1.00
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery 0.38
TMEM65 functions as the mitochondrial Na+/Ca2+ exchanger 1.00
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH 0.97
ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome 0.89
Extracellular exosomal RNAs are glyco-modified 1.00
22 14.73
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation 1.00
Trafficking of a nitrogenase FeMo-cofactor assembly intermediate 0.40
A family portrait of lanmodulin selectivity for enhanced rare-earth separations 1.00
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core 0.21
A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 0.71
Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation 0.14
Uncovering bacterial pseudaminylation with pan-specific antibody tools 0.09
Inhibitory probes for spatiotemporal analysis of Gαs protein signaling 1.00
Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates 1.00
Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 0.24
Directed evolution of functional intrinsically disordered proteins 1.00
A single allosteric site merges activation, modulation and inhibition in TRPM5 1.00
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates 0.73
Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning 0.33
SINE compounds activate exportin 1 degradation through an allosteric mechanism 0.76
Molecular basis for noncanonical transcription initiation from Np4A alarmones 1.00
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics 1.00
Real-time imaging of protein microenvironment changes in cells with rotor-based fluorescent amino acids 1.00
Site-selective protein editing by backbone extension acyl rearrangements 1.00
ApaH decaps Np4N-capped RNAs in two alternative orientations 1.00
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1 0.05
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R 0.05
6 3.89
Emergence of specific binding and catalysis from a designed generalist binding protein 0.91
Developing design guidelines for controlling charge transport in DNA 0.60
Stepwise and reversible assembly of [2Fe–2S] rhombs to [8Fe–8S] clusters and their topological interconversions 0.18
Navigating protein landscapes with a machine-learned transferable coarse-grained model 0.20
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini 1.00
The biophysical requirements that govern the efficient endosomal escape of designed mini-proteins 1.00
287 209.63
Fmp30p is a mitochondrial phosphatidylinositol hydrolase that modulates CoQ biosynthesis 1.00
Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages 0.20
RNAs anchoring replication complex control initiation and firing of DNA replication 0.93
Open-channel block of human TRPV6 by polyamine spermine 0.25
Early hexapod genomes reveal the deep origin of insect gustatory and odorant receptors 1.00
A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity 1.00
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma 0.93
Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter 0.86
Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids 1.00
Chaperone-mediated autophagy is required for regulatory T cell function 1.00
A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation 0.11
Long-term temporal stability of circulating proteins in older adults 0.38
Dynamic regulation of origin firing factors links CDK activity to dormant origin activation 1.00
N-glycopedia: libraries for native N-glycan structural analysis 0.83
DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis 0.11
Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart 1.00
SIRT6 overexpression counteracts chromatin aging in the male murine liver 0.29
Site-specific glycosylation of Sec24D and myoferlin recruit ERGIC to ER exit sites for collagen trafficking 1.00
Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA–dependent immunity in breast cancer 0.04
Multiscale machine learning molecular mechanics for mechanism and stereoselectivity of Diels-Alderase catalysis 1.00
A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis 0.19
Endosome maturation is orchestrated by inside-out proton signaling through a Na/H exchanger and pH-dependent Rab GTPase cycling 1.00
Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion 0.97
Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase 0.80
Selective positive allosteric modulation of β2AR using antibody fragments targeting the third intracellular loop 1.00
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities 0.17
AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration 0.04
Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi 0.40
Networked salt-bridges mediate magnesium-dependent conformational dynamics and functional regulation in type IA topoisomerases 1.00
SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis 0.33
Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells 0.87
Probing molecular diversity and ultrastructure of brain cells with fluorescent aptamers 1.00
An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles 0.20
High-throughput single-vesicle imaging platform for direct extracellular vesicle profiling of human plasma 1.00
Mitochondrial respirasome-like supercomplexes support metabolic flexibility in yeast 0.63
DNA deformability in sequence-dependent capture of E. coli gyrase 0.70
Structural basis of QueC-family protein function in qatABCD anti-phage defense 1.00
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira 0.12
Structural basis for protein-free catalysis by ribonuclease P ribozyme 1.00
Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial Ca2+ 1.00
Engineering of genetically encoded programmable calcium channel inhibitory binders 1.00
A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread 0.75
Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks 1.00
Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits 0.97
Mechanism of lipid-dependent cold sensitivity in a model ion channel 1.00
Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2 1.00
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency 0.71
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis 0.85
A highly limited amino acid library from asteroid Bennu yields wide-ranging protein folds 0.88
Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice 1.00
Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model 0.07
Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis 0.75
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia 1.00
Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation 1.00
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability 0.92
Deep homology and design of proteasome chaperone proteins in Candidozyma auris 1.00
Mad1 facilitates α5 integrin trafficking from the Golgi to promote abscission during cytokinesis 1.00
Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration 1.00
Ceramide disrupts TM9SF2-PGK1 axis to redirect PD-L1 trafficking and enhance antitumor immunity 0.06
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers 0.09
Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice 0.14
Substrate-interacting pore loops of two ATPase subunits determine the degradation efficiency of the 26S proteasome 1.00
GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis 0.83
Ultrathin crown ether-based polyamide membrane for ion-ion separations 0.94
Cooperativity in E. coli aspartate transcarbamoylase is tuned by allosteric breathing 1.00
Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain 1.00
Chromatin reorganization drives overexpression of a Btaf1 variant underpinning hematopoietic aging 1.00
Molecular mechanism of menthol-induced TRPV5 channel inhibition 0.33
Synchronous activation of striatal cholinergic interneurons induces local serotonin release 0.43
Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B 0.08
Structural basis and regulation of GSDME pore formation 0.75
Molecular insights into the regulation of GNPTαβ by LYSET 1.00
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells 0.07
CF2H: a cell-free two-hybrid platform for rapid protein binder screening 0.17
CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling 0.33
Adaptations in tubulin determine distinct microtubule architectures, mechanics and drug susceptibility 0.38
Design-driven optimization of low-cost reagent formulations for reproducible and high-yielding cell-free gene expression 0.94
Velocity sensitivity of mechanotransduction in the afferent terminal underlies vibration detection in the Pacinian corpuscle 1.00
Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa 0.56
ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex 0.11
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor 1.00
Identification and engineering of highly functional potyviral proteases in cells using co-evolutionary models 1.00
An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing 1.00
Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences 0.45
Villification of the intestinal epithelium is driven by Foxl1 through activation of PDGFRα and BMPs 1.00
Harnessing a germ‑free mouse gut bioreactor for directed evolution of probiotics to combat non-alcoholic fatty liver disease 0.10
A protein adaptor mediating Ap4A-dependent control of protein acetylation 0.22
VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement 0.03
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy 1.00
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response 1.00
Conformational biosensors delineate endosomal G protein regulation by GPCRs 0.83
The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment 0.89
Supercoiled DNA recognition and cleavage control in topoisomerase VI 1.00
Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression 1.00
Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice 0.22
Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1 1.00
NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis 1.00
Structural basis of TACO1-mediated efficient mitochondrial translation 1.00
FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions 1.00
The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition 0.78
Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes 0.95
Insights into the structure and modulation of human TWIK-2 1.00
Trustworthy prediction of enzyme commission numbers using a hierarchical interpretable transformer 0.40
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation 1.00
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy 0.86
A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor 0.29
Dynamic signature of activity-stability tradeoff in lactamase evolution 1.00
Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1 1.00
Integrative epigenetics and transcriptomics identify aging genes in human blood 0.76
Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice 1.00
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis 0.90
Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation 0.10
Sequence-based generative AI design of versatile tryptophan synthases 1.00
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM 1.00
Small molecule splicing modulators that disrupt O-GlcNAc homeostasis 1.00
Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome 0.43
Improved protein binder design using β-pairing targeted RFdiffusion 0.80
Molecular mechanism of exchange coupling in CLC chloride/proton antiporters 0.75
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis 0.50
A universal polyphosphate kinase powers in vitro transcription 0.08
Structural basis for the subtype-selectivity of KCa2.2 channel activators 0.80
Learning the language of protein-protein interactions 1.00
-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release 0.11
Capsaicin diet drives gut inflammation and exosomal miR-17-3p elevation in idiopathic short stature 0.22
Comparing cryo-EM methods and molecular dynamics simulation to investigate heterogeneity in ligand-bound TRPV1 1.00
Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival 1.00
Stable de novo protein design via joint conformational landscape and sequence optimization 0.90
Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy 1.00
4EHP and NELF-E regulate physiological ATF4 induction and proteostasis in disease models of Drosophila 0.83
Generalizable and scalable protein stability prediction with rewired protein generative models 1.00
Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications 0.82
Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis 1.00
A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system 1.00
Characterization of the GTPγS release function of a G protein-coupled receptor 1.00
PhaseT3M: 3D imaging at 1.6 Å resolution via electron cryo-tomography with nonlinear phase retrieval 1.00
Enantioselective protein affinity selection mass spectrometry (E-ASMS) 0.12
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes 0.55
The ribosome derives the energy to translocate and unwind mRNA from EF-G binding 1.00
Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice 0.97
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether 1.00
De novo sequencing of glycans by ion mobility-mass spectrometry using a self-expanding database 0.30
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity 0.07
HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing 0.93
Elevated intracellular copper induces CTR1 monomerization and prevents copper uptake 1.00
Mitochondria are absent from microglial processes performing surveillance, chemotaxis, and phagocytic engulfment 1.00
Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types 1.00
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera 1.00
Ran modulates allosteric crosstalk between importin β surfaces 1.00
Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity 0.03
Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer 1.00
Dynamic changes in chloride homeostasis coordinate midbrain inhibitory network activity during reward learning 1.00
Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles 0.11
Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1 1.00
The genetic and biochemical basis of human leading strand synthesis 0.08
Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc 0.13
Development of a p62 biodegrader for autophagy targeted degradation 0.13
Protein Kinase A and assembly of an ABCC4 protein network 1.00
Tuneable ion selectivity in vermiculite membranes intercalated with unexchangeable ions 0.05
Rapid estimation of protein folding pathways from sequence alone using AlphaFold2 1.00
Visualizing the translation landscape in human cells at high resolution 1.00
Disruption of the PIKfyve complex unveils an adaptive mechanism to promote lysosomal repair and mitochondrial homeostasis 1.00
Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors 1.00
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export 1.00
Investigating the neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies 0.33
Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth 0.28
Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1) 0.88
Torsion is a dynamic regulator of DNA replication stalling and reactivation 1.00
Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference 1.00
Latent-TGF-β has a domain swapped architecture 1.00
Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle 0.13
53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes 1.00
Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation 1.00
The implications of alternative splicing regulation for maximum lifespan 1.00
Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels 0.05
Disentangling the mechanistic role of loop-C capping in Cys-loop receptor activation 1.00
Protein Set Transformer: a protein-based genome language model to power high-diversity viromics 0.89
The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor 1.00
Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration 0.20
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets 0.50
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids 0.19
The dynamic lateral gate of the mitochondrial β-barrel biogenesis machinery is blocked by darobactin A 0.87
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies 1.00
A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin 0.95
DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans 1.00
GABA-independent activation of GABAB receptor by mechanical forces 0.17
The locking mechanism of human TRPV6 inhibition by intracellular magnesium 0.25
Extracellular filaments revealed by affinity capture cryogenic-electron tomography 0.87
Mechanism of Arp2/3 complex branch disassembly by human Coro7 0.80
Pmt4 recognizes two separate acceptor sites to O-mannosylate in the S/T-rich regions of substrate proteins 1.00
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging 0.09
Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides 0.78
Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding 1.00
Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel 1.00
Engineering unnatural cells with a 21st amino acid as a living epigenetic sensor 1.00
And-1 coordinates with polymerase δ to regulate nucleotide excision repair and UVB-induced skin tumorigenesis 1.00
Visualization of lysosomal membrane proteins by cryo electron tomography 1.00
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome 0.08
Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks 0.73
The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size 0.60
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study 0.78
Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation 0.08
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan 1.00
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1 1.00
Data-driven fine-grained region discovery in the mouse brain with transformers 1.00
Sensitive, high-throughput, metabolic analysis by molecular sensors on the membrane surface of mother yeast cells 0.15
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 0.15
Calmodulin binding is required for calcium mediated TRPA1 desensitization 1.00
Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release 0.20
SARST2 high-throughput and resource-efficient protein structure alignment against massive databases 0.19
V-ATPase-dependent induction of selective autophagy 1.00
A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation 1.00
Structural basis for ligand promiscuity and high signaling activity of Kaposi’s Sarcoma-associated Herpesvirus-encoded GPCR 1.00
Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission 1.00
Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading 0.83
Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH 1.00
DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides 1.00
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity 1.00
An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification 0.05
Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis 1.00
Probiotic acoustic biosensors for noninvasive imaging of gut inflammation 1.00
Large protein databases reveal structural complementarity and functional locality 0.33
A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism 1.00
Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping 0.44
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes 0.18
Single extracellular vesicle imaging via rolling circle amplification–expansion microscopy 0.14
Structural basis for membrane microdomain formation by a human Stomatin complex 1.00
Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity 1.00
Lipid interactions and gating hysteresis suggest a physiological role for mechanosensitive channel YnaI 0.63
A covalent organic framework membrane with highly selective and permeable artificial sodium channels via ion recognition 0.22
Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function 1.00
Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy 1.00
Lipid-mediated gating of a miniature mechanosensitive MscS channel from 1.00
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules 0.10
Characterizing and engineering post-translational modifications with high-throughput cell-free expression 1.00
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release 0.96
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies 0.88
Arp2/3 and type-I myosins control chromosome mobility and end-resection at double-strand breaks in 1.00
Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions 0.14
Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions 1.00
Development and application of GlycanDIA workflow for glycomic analysis 0.89
A dedicated skin-to-brain circuit for cool sensation in mice 1.00
Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier 0.84
Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases 0.05
Deep-learning structure elucidation from single-mutant deep mutational scanning 1.00
Te and Fe nuclear resonance vibrational spectroscopic characterization of intermediate spin state mixed-valent dimers 0.22
The bile acid-sensitive ion channel is gated by Ca-dependent conformational changes in the transmembrane domain 1.00
Basement membrane perforations guide anterior–posterior axis formation 0.95
Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis 0.92
Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex 1.00
Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform 1.00
Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids 0.95
Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation 0.29
Endogenous tyrosinase-catalyzed therapeutics 1.00
Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase 1.00
Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior 1.00
A high-performance genetically encoded sensor for cellular imaging of PKC activity in vivo 1.00
The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex 1.00
Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete 0.09
Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis 1.00
Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria 1.00
MIC: A deep learning tool for assigning ions and waters in cryo-EM and crystal structures 1.00
Structural-functional characterization of the MIRO1-TRAK1 complex 1.00
The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases 0.87
A single main-chain hydrogen bond required to keep GABAA receptors closed 0.56
Nanostructured organic sheets sequestering small extracellular vesicles and reactive species to protect against radiation-induced mucositis 0.15
Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos 1.00
An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies 1.00
Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association 1.00
Cooperative and inhibitory ion transport in functionalized angstrom-scale two-dimensional channels 0.97
New molecular components of high and low affinity iron import systems in Drosophila 0.20
Transcriptional landscape of the cell cycle in a model thermoacidophilic archaeon reveals similarities to eukaryotes 0.07
Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity 0.98
A generalized platform for artificial intelligence-powered autonomous enzyme engineering 1.00
Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure 1.00
Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis 1.00
Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors 1.00
Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI 0.88
Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology 1.00
The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice 1.00
TUG protein acts through a disordered region to organize the early secretory pathway 0.77
Molecular mechanism of Activin receptor inhibition by DLK1 1.00
Reversible proliferative arrest induced by rapid depletion of RNase MRP 1.00
TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family 0.50
Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions 0.33
An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins 0.72
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells 0.06
Control of tissue flows and embryo geometry in avian gastrulation 0.40
2 0.15
Mutational scanning reveals oncogenic mutations have diverse effects on signaling 0.08
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation 0.07
5 4.09
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency 1.00
Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity 1.00
Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire 0.69
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation 1.00
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age 0.40
1 0.07
Mechanisms of active wetting and fluidification in epithelial cell collectives 0.07
5 2.11
The exposome of brain aging across 34 countries 0.10
Shared and specific blood biomarkers for multimorbidity 0.14
MRI-based multi-organ clocks for healthy aging and disease assessment 0.80
The exposome of healthy and accelerated aging across 40 countries 0.07
Plasma proteomics links brain and immune system aging with healthspan and longevity 1.00
19 17.62
AreTomoLive: automated reconstruction of comprehensively corrected and denoised cryo-electron tomograms in real time and at high throughput 1.00
FILM: mapping organellar metabolism by mid-infrared photothermal-modulated fluorescence 1.00
eSIG-Net: an interaction language model that decodes the protein code of single mutations 1.00
AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network 0.42
Quantifying uncertainty in protein representations across models and tasks 1.00
Compressing the collective knowledge of ESM into a single protein language model 1.00
AF2BIND: predicting small-molecule binding sites using the pair representation of AlphaFold2 0.83
MultiCell: geometric learning in multicellular development 1.00
Atom-level enzyme active site scaffolding using RFdiffusion2 1.00
ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms 0.92
InterPLM: discovering interpretable features in protein language models via sparse autoencoders 1.00
Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy 1.00
GPU-accelerated homology search with MMseqs2 0.45
Biophysics-based protein language models for protein engineering 1.00
A realistic phantom dataset for benchmarking cryo-ET data annotation 1.00
PANCS-Binders: a rapid, high-throughput binder discovery platform 1.00
Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions 1.00
A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data 1.00
CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets 1.00
3 1.10
DNA nanodevice for analysis of force-activated protein extension and interactions 1.00
Meso–macroporous hydrogel for direct litre-scale isolation of extracellular vesicles 0.07
An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing 0.03
4 2.69
Molecular mechanism of calcium permeability and magnesium block in NMDA receptors 1.00
Munc18 modulates syntaxin phase separation to promote exocytosis 0.36
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease 0.86
Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment 0.46
1 0.40
Obstacles regulate membrane tension propagation to enable localized mechanotransduction 0.40
23 19.19
Rap1-mediated steric hindrance protects telomeres from MRX sensing 0.12
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway 0.81
Structural insights into coffee bitter taste perception by TAS2R43 receptor 1.00
Calcium dependent activation of the TMEM16F scramblase and ion channel 1.00
Atomic models of the Toxoplasma cell invasion machinery 1.00
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation 0.70
AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt 1.00
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1 1.00
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel 1.00
Structural basis for agonist and heat activation of nociceptor TRPM3 1.00
Global analysis of translocon remodeling during protein synthesis at the ER 0.67
Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer 1.00
Computational design of sequence-specific DNA-binding proteins 0.98
Establishment of the phagophore–ERES membrane contact site initiates phagophore elongation 0.10
Structure of the TXNL1-bound proteasome 1.00
Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P2 0.33
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics 0.75
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients 1.00
SNARE disassembly requires Sec18/NSF side loading 1.00
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration 1.00
P-type ATPase magnesium transporter MgtA acts as a dimer 0.73
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation 1.00
Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 1.00
8 6.90
SARM1 executes neuronal parthanatos and promotes excitotoxic cell death 1.00
Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion 1.00
TMEM145 is a principal component of outer hair cell stereocilia 0.08
Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity 1.00
CLN3 mediates chloride efflux from lysosomes 1.00
Ultrastructural membrane dynamics of mouse and human cortical synapses 0.82
Structural and functional basis of mechanosensitive TMEM63 channelopathies 1.00
A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses 1.00
17 13.47
Type II tRNA cleavage by SLFN14 endoribonuclease variants linked to inherited thrombocytopenia drives global translational repression 0.92
Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans 1.00
Cdc42 interacts with chaperone Ydj1 to enhance its stability and partitioning during asymmetric cell division and aging in yeast 0.75
Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans 0.90
The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development 1.00
Calcium signaling regulates apoptosis-induced proliferation in Drosophila 0.50
Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue 0.96
The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors 1.00
Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling 1.00
The Ync13–Rga7–Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis 0.71
Calcium signaling is required for anterior patterning in the mouse embryo 0.07
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C. 1.00
Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms. 1.00
Expansion of lysosomal capacity in early adult neurons driven by TFEB/HLH-30 protects dendrite maintenance during aging in Caenorhabditis elegans. 1.00
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction. 0.08
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice. 0.81
Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163. 0.75
10 6.38
Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization in C. elegans 0.29
Spatiotemporal characterization of single-stranded DNA intermediates after UV irradiation: II. Rapid growth and effects of recA and recJ 0.40
PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking 1.00
An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum 0.25
Topo IV is required to allow replisomes to converge and complete replication on the chromosome. 1.00
Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity 1.00
A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish 0.44
Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis 0.25
An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. 0.75
The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish 1.00
1 0.90
Efficacy of biomarkers in the endochondral phase of fracture repair and healing in long bones: A clinical observational studys 0.90
2 2.00
Cooperative Native Contact Formation Facilitates Free Energy Barrier Crossing in Protein Folding 1.00
Scaling Law for Epithelial Tissue Rheology 1.00
1 1.00
Learning Geometric Models for Developmental Dynamics 1.00
1 0.18
<atl>Staurosporine Targets Mitochondrial Regulator scpVdAtuA3/scp to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt</atl> 0.18
158 131.24
Epithelial cell fusion is required for tissue repair following UV-A irradiation 1.00
Acoel whole-body regeneration begins with spreading, multi-tissue ERK signaling downstream of neuregulin-1 1.00
Predictions from deep learning propose substantial protein–carbohydrate interplay 1.00
Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB 0.40
D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes 1.00
Simultaneous multielectrode recordings along the human scala tympani: Evidence for level-dependent place coding 1.00
Importin-9 recognizes the winged-helix fold of ETS transcription factors to mediate nuclear import 1.00
Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α 1.00
HIV-1 infection induces Vif-mediated SUMOylation of host RNA splicing factors important for proper viral RNA splicing 1.00
Mechanism of MutLβ-dependent DNA expansions 1.00
PMF proteins mediate mitochondrial fusion in Arabidopsis 1.00
Self-cleavage-dependent and -independent functions of Adgrg1/Gpr56 in mice 1.00
Transsynaptic linking of calcium channels and postsynaptic receptors at a dyadic synapse 1.00
Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold 1.00
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases 0.83
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks 1.00
Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism 1.00
Fitting coarse-grained models to macroscopic experimental data via automatic differentiation 0.75
CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis 0.06
Chromatin accessibility regulates age-dependent nuclear mechanotransduction 0.50
VAMP8 function reveals tight linkage between endocytic recycling and endocytosis 0.08
The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models 1.00
Selective fluorination of Fc glycans enhances antibody-mediated effector functions 1.00
Dual-encoder contrastive learning accelerates enzyme discovery 1.00
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum 1.00
SEL1L–HRD1 ERAD–autophagy interplay maintains mitochondrial homeostasis in brown adipocytes 0.92
Influence of extracellular magnesium ions on the functional state and biophysical and structural properties of connexin36 hemichannels 0.11
Single-cell analyses identify independent aging processes that compete to determine cellular fate in budding yeast 1.00
Bias in the AlphaFold3 prediction of ligand-induced domain motion in enzymes 1.00
FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid–dependent viral infections 1.00
Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions 0.47
Unified protein–small molecule graph neural networks for binding site prediction 1.00
The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry 1.00
Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition 1.00
Capturing ribosomal structures in cellular extracts with cryoPRISM: A purification-free cryoEM approach reveals novel structural states 1.00
Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis 1.00
Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells 1.00
Aging-associated differences in mammary tumor–initiating populations and immune evasion pathways in breast cancer 0.73
Cryogenic electron tomography by the numbers: Charting underexplored lineages in structural cell biology 1.00
Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating 0.95
Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations 1.00
GSK-3β coordinates axonal microtubule organization through Shot and Tau 0.11
Synaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles 0.79
Learning nature’s assembly language with polymers 1.00
Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels 0.47
Structural analysis of rhodopsin states in megabody complexes 0.80
RPA-independent activation of the ATR/CHK1 pathway 1.00
Structural basis for pseudokinase-mediated regulation of GCN2 in the integrated stress response 1.00
Intronic polyadenylation–derived long noncoding RNA modulates nucleolar integrity and function 1.00
RecBCD-dependent post-UV replication restart in Escherichia coli triggers fork triplication 1.00
Caspase-3 cleaves and activates the NADase SARM1 to promote apoptosis, linking two cell death mechanisms 1.00
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis 0.33
Cortical O2 supply and metabolism are suppressed in the aged mice 1.00
Protein language models trained on biophysical dynamics inform mutation effects 1.00
A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo 1.00
Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation 1.00
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter 0.92
Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type–specific codependence for trafficking through the Golgi 1.00
Dosa: A method to covalently barcode proteins for high-throughput biochemistry 1.00
Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap–Insig interaction and SREBP activation 1.00
DNA mismatch repair mediated by Mlh1–Pms1 endonuclease-catalyzed mispair excision 1.00
Energetic and structural control of polyspecificity in a multidrug transporter 1.00
ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation 1.00
DIS3L2-mediated RNA surveillance and extracellular vesicle packaging prevent innate immune activation by aberrant cellular RNAs 1.00
Asymmetrical recognition and processing of double-strand breaks formed during DNA replication 1.00
Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry 1.00
Actin network heterogeneity tunes activator–inhibitor dynamics at the cell cortex 1.00
Structural modeling reveals the allosteric switch controlling the chitin utilization program of Vibrio cholerae 1.00
An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somite organization 1.00
Reconstructing Waddington’s landscape from data 0.50
<atl>Preassembly and independent trafficking of the exocyst complex in iArabidopsis/i</atl> 0.09
The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling 1.00
The intermediate filament protein GFAP regulates mitochondrial fission in astrocytes 0.55
Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells 0.86
Actin isoform–specific interactions revealed by Vibrio VopV actin-binding repeats 1.00
Reaching the full potential of cryo-EM reconstructions with molecular dynamics simulations at 310 K: Actin filaments as an example 1.00
SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules 1.00
The telomeric valine–arginine dipeptide repeat protein changes state to diffuse staining in mitosis and represses in vitro translation 1.00
The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity 1.00
Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1 1.00
The configurational length scale in the self-assembly and modulation of higher-order transient protein structures 1.00
The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5 0.29
The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation 1.00
mTORC1 regulates autophagosomal components recycling through SNX16 phosphorylation 0.10
Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation 0.30
A cascade of structural rearrangements positions peptide release factor 2 for polypeptide hydrolysis on the ribosome 1.00
PCNA is a nucleotide exchange factor for the clamp loader ATPase complex 1.00
Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism 0.25
FZD7 expression marks mammary tumor–initiating cells 1.00
Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance 0.12
Methanogenic archaea encoding Pyrrolysine maintain ambiguous amber codon usage 1.00
LHFPL5 is required for maximal activation of the mechanotransduction channel in cochlear hair cells 1.00
Mapping the placental galectin-3 interactome identifies CD9 and ITGB1 as functional glycoprotein counterreceptors during syncytialization 1.00
Modeling protein–small molecule conformational ensembles with PLACER 1.00
Accurate site-specific folding via conditional diffusion based on AlphaFold3 1.00
Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone 1.00
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency 1.00
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking 0.09
Differential O-glucose elongation on a specific EGF repeat within the canonical ligand–binding domain regulates DLL1/4-NOTCH1 signaling 0.08
A protein dynamics–based deep learning model enhances predictions of fitness and epistasis 1.00
Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport 0.73
Substrate-dependent activation of LONP1 informs on proteolytic regulation and ATPase motor function 1.00
Mitotic recombination events and single-base mutations induced by ultraviolet light in G1-arrested yeast cells 0.33
Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen–presenting cell network 0.21
Temperature adaptation in structure and function in lactate dehydrogenase-A reflects convergent evolution in a few key protein regions 0.20
Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies 1.00
STAR/STARD1: A mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy 1.00
Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia 0.85
Design principles of the common Gly-X6-Gly membrane protein building block 1.00
An Orc6 tether mediates ORC binding-site switching during replication origin licensing 1.00
5′-terminal glycosylation of protein-coding transcripts: An epitranscriptomic modification that prolongs mRNA lifetimes 1.00
ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design 1.00
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway 0.04
A Campylobacter jejuni sensor phosphatase–driven two-component system integrates metabolic phosphodonors as cues in signal transduction 1.00
Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies 1.00
A model for boundary-driven tissue morphogenesis 0.67
PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism 1.00
DNA-utilization loci enable exogenous DNA metabolism in gut Bacteroidales 1.00
Functional unfolding of the integrin αX transmembrane helix 0.71
Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma 0.97
Parametrically guided design of beta barrels and transmembrane nanopores using deep learning 1.00
More 26S and 30S proteasomes are beneficial in proteinopathy 0.07
Improving the efficacy of anti-SSEA4 antibody in pancreatic cancer immunotherapy with glyco-optimization and immune checkpoint blockade 0.21
Subtype-specific structural features of the hearing loss–associated human P2X2 receptor 0.39
DNA polymerase α-primase can function as a translesion DNA polymerase 1.00
Measuring multisubunit mechanics of geometrically programmed colloidal assemblies via cryo-EM multi-body refinement 1.00
Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses 1.00
Nonlinear memory in cell-division dynamics across species 1.00
Protein functional site annotation using local structure embeddings 1.00
Loss of sialic acid side-chain O-acetylation exacerbates colitis 1.00
Aspartic acid residues in BBE-like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation 0.19
Sparse autoencoders uncover biologically interpretable features in protein language model representations 1.00
O-GlcNAc modulation of nuclear pore complexes orchestrates mRNA export efficiency 1.00
Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation 1.00
Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan 0.91
Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation 0.37
Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species 0.10
In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment 0.88
Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms 1.00
Structural basis for the evolution of a domesticated group II intron–like reverse transcriptase to function in host cell DNA repair 1.00
The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge 1.00
Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects 1.00
N-acetyltransferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in Mycobacterium marinum 1.00
Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes 0.17
Dynamic forces drive cell and organ morphology changes during embryonic development 0.96
Amplification through local critical behavior in the mammalian cochlea 1.00
Autophagic stress activates distinct compensatory secretory pathways in neurons 1.00
Regulation of the ordinal DNA translocation cycle in bacteriophage Φ29 through trans-subunit interactions 1.00
A privileged ER compartment for posttranslational heteromeric assembly of an ion channel 1.00
Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F 1.00
Molecular contacts in self-assembling clusters of membrane proteins 1.00
ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection 1.00
Metabolic control of glycosylation forms for establishing glycan-dependent protein interaction networks 0.80
Ligand-specific regulation of a binary enhancer code dictating cellular senescence 1.00
A proteomic signature of healthspan 0.50
Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference 0.57
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography 1.00
A mouse model of Jansen’s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics 0.97
2 1.76
Repeated experimental challenges do not shorten adult telomeres in a songbird 1.00
Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon. 0.76
25 20.43
Implantable living materials autonomously deliver therapeutics using contained engineered bacteria 1.00
A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress 1.00
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response 1.00
Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging 1.00
Rapid directed evolution guided by protein language models and epistatic interactions 1.00
Evolution of error correction through a need for speed 0.64
Structural ontogeny of protein-protein interactions 1.00
Aging drives a program of DNA methylation decay in plant organs 1.00
Cellular survivorship bias as a mechanistic driver of muscle stem cell aging 1.00
Computational design of conformation-biasing mutations to alter protein functions 1.00
Cohesin drives chromatin scanning during the RAD51-mediated homology search 0.91
An archaeal genetic code with all TAG codons as pyrrolysine 0.68
<atl>Retinal calcium waves coordinate uniform tissue patterning of the iDrosophila/i eye</atl> 1.00
PIEZO channels link mechanical forces to uterine contractions in parturition 0.98
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling 0.08
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling 1.00
Intercellular communication in the brain through a dendritic nanotubular network 0.78
Strengthening nucleic acid biosecurity screening against generative protein design tools 0.83
Predicting protein-protein interactions in the human proteome 0.67
An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli 1.00
Altered translation elongation contributes to key hallmarks of aging in the killifish brain 0.07
Controlled colonization of the human gut with a genetically engineered microbial therapeutic 1.00
Scalable emulation of protein equilibrium ensembles with generative deep learning 0.02
Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome 0.83
Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape 0.93
74 54.47
Multicellular senescence impairs skeletal muscle recovery following disuse in aging 1.00
Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicity 0.85
An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling 0.07
Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET) 0.07
High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer–weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness 1.00
Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway 1.00
A cross-tissue physicochemical causal chain underlying vertebrate mandibular morphogenesis 0.08
RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages 0.07
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine 1.00
Nanopore-based sequencing of active DNA replication reveals key principles of metazoan replication dynamics 1.00
Repertoire-scale antibody structural prediction informs therapeutic design 1.00
Multitissue, multi–time point transcriptomic atlas of aging in mice and rats 1.00
From vibrations to function: Spectroscopic detection and quantification of π-π stacking in drug-responsive protein complexes 1.00
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome 1.00
Nuclear translocation of β-catenin in Wg/Wnt signaling via the IFT-A microtubule–associated complex requires Pasovec/Gid8 proteins 1.00
Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction 1.00
Harnessing cooperative sorbate-sorbent adaptation in a flexible metal-organic framework for switchable hydrocarbon separation 0.22
Fast sampling of protein conformational dynamics 1.00
A small-molecule stabilizer of the calpastatin–calpain-2 complex restores mitochondrial function and mitigates neurodegeneration 1.00
Transcription activation mechanism of a noncanonical DNA damage response pathway by the WYL-activator, DriD 1.00
Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex 1.00
Conformational dynamics of SARS-CoV-2 spike on a membrane reveals the allosteric effects of furin cleavage and the D614G mutation 1.00
Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread 0.82
Weaker neuroligin 2–neurexin β1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering 1.00
Transmembrane proteins mediate basal complex assembly and individual daughter cell formation in malaria parasites 0.79
The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior 1.00
Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer 0.09
Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation 0.27
Matrix-bound nanovesicles as epigenetic modulators of myeloid cells 1.00
Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loop 1.00
Molecular and structural basis of a subfamily of PrfH rescuing both the damaged and intact ribosomes stalled in translation 0.57
A transposase-derived gene required for human brain development 0.49
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes 0.86
The structure of an actin nucleus stabilized by villin 0.33
Atom-level machine learning of protein-glycan interactions and cross-chiral recognition in glycobiology 0.17
Open access Research Article BIOCHEMISTRY Share on Mitochondrial NAD+ gradient sustained by membrane potential and transport 1.00
Dynamic structures of a membrane transporter in native cellular membranes 0.10
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function 0.19
The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis 1.00
l-Fucose is a candidate monosaccharide neuromodulator and mitigates Alzheimer’s synaptic deficits 1.00
Pharmacological targeting of RIG-I can selectively activate the integrated stress response 1.00
Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function 0.33
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism 1.00
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection 1.00
A phosphoinositide switch from PI(4,5)P2 to PI4P triggers endocytosis by inducing dynamin-mediated fission in secretory cells 1.00
Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins 1.00
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles 0.18
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy 1.00
The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans 1.00
Mechanochemical waves in focal adhesions during cell migration 0.67
Age-related remodeling of the sialoglycans dampens murine CD8+ T cell function 0.83
A sensory and motor neuropathy caused by a genetic variant of NAMPT 0.33
Molecular exaptation by the integrin αI domain 1.00
Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice 1.00
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress 1.00
AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration 0.09
Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos 0.19
Structures of MmpL complexes reveal the assembly and mechanism of this family of transporters 1.00
Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors 1.00
Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations 0.46
GTP hydrolysis triggers membrane remodeling by AMPH-1 1.00
Formation control between leader and migratory follower tissues allows coordinated growth 0.47
Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A 1.00
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex 0.81
Ion channel structure and function of the MERS coronavirus E protein 0.44
Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity 1.00
Integrated in vivo functional screens and multiomics analyses identify α-2,3-sialylation as essential for melanoma maintenance 0.88
Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease 0.16
ZC3H4 safeguards genome integrity by preventing transcription-replication conflicts at noncoding RNA loci 0.57
Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain 0.27
Conformational dynamics and multimodal interaction of Paxillin with the focal adhesion targeting domain 1.00
Spermidine is a key polyamine required by intracellular parasites for survival within host erythrocytes 0.75
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination 1.00
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection 1.00
2 1.71
Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease 0.71
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus 1.00
15 10.38
FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology 0.11
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression 1.00
Novel tissue mechanics-guided cellular flows drive the formation of feather follicles 0.43
SenSet defines cell-type specific senescence signatures in the aged human lung 0.92
AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms 1.00
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin–mediated mitophagy 0.90
Glycogen phase-separation drives macromolecular rearrangement and asymmetric division in E. coli 0.91
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues 0.82
Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease. 0.03
PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis. 0.13
BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM 1.00
Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes. 1.00
Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. 0.50
Lipid transporters E-Syt3 and ORP5 regulate epithelial ion transport by controlling phosphatidylserine enrichment at ER/PM junctions 0.63
The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue 1.00
1 0.20
Wasp intestinal cues drive yeast toward outbreeding strategies 0.20
3 3.00
Cation-Assisted Surfactant Templating of DNA at the Air–Water Interface: New Insights into Nucleic Acid Surface Activity 1.00
Extrapolating Foundation Generative Models with Physics: A Case Study of Exploring Peptide Conformations under Protein–Environment Interactions 1.00
Conformational Dynamics and Activation of Membrane-Associated Human Group IVA Cytosolic Phospholipase Asub2/sub (cPLAsub2/sub) 1.00
2 0.36
FaNUDT19 contributes to 5′ cap quality control by modulating NAD+ capped RNA dynamics during strawberry fruit ripening 0.25
NUP50c defines a conserved nuclear basket module with NUP82 and NUP136 to mediate mRNA export and gene regulation in plants 0.11

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